Clinical trials: Nervous System Disorders
Upper Extremity Dysfunction, Gait, Unsteady
The Effect of Improvement in Function on Foot Pressure, Balance and Gait in Children With Upper Extremity Affected
It has been shown that movements of the upper extremity during walking are associated with lower extremity mobility. For example, when walking at a slow pace, the swing frequency of the arms is 2: 1 compared to the legs, while…
- Conditions
- Upper Extremity Dysfunction, Gait, Unsteady, Juvenile Idiopathic Arthritis, Balance
- Trial name
- NCT04671524
- Testing
- Exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Alzheimer's Disease
OmegAD (Omega-3 and Alzheimer's Disease)
Memory loss and difficulties with thinking associated with Alzheimer's disease (AD) may be due to a deficiency in the brain of a fatty acid named DHA.
- Trial name
- NCT00211159
- Testing
- EPAX 1050TG
- Where
- Sweden
- Volunteers
- 204 people
- Sponsor
- Karolinska University Hospital
Neurodegenerative Disease
Cause and Pathogenesis of Neurometabolic Disorders
This study will examine the origin and development of certain neurological diseases involving abnormal metabolism. A significant number of patients with progressive neurological disorders have not been diagnosed despite extensive…
- Trial name
- NCT00016562
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
High Altitude Pulmonary Hypertension, Sleep Apnea
Sleep Related Breathing Disturbances and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders
High altitude pulmonary hypertension, a form of altitude illness that occurs in long-term residents at altitudes >2500 m, is characterized by dyspnea, hypoxemia, impaired exercise performance and hypertension in the pulmonary…
- Trial name
- NCT01621061
- Where
- Kyrgyzstan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Encephalitis, Central Nervous System Infections and Inflammations
Brazil ICU Encephalitis Surveillance
Our proposal is to develop a sentinel syndromic surveillance strategy to identify encephalitis cases possibly related to emerging pathogens admitted to ICUs in Brazil.
- Conditions
- Encephalitis, Central Nervous System Infections and Inflammations, Intensive Care Neurological Disorder, Prognosis
- Trial name
- NCT05370573
- Testing
- No intervention
- Where
- Brazil
- Volunteers
- 451 people
- Sponsor
- D'Or Institute for Research and Education
Traumatic Brain Injury, Subarachnoid Hemorrhage
Cerebral Perfusion Pressure (CPP) Management Information Feedback and Nursing
The aim of the initial proposal was to evaluate, in the context of optimal medical management, the impact of a bedside system of cerebral perfusion pressure (CPP) information feedback on nursing moment-to-moment management of…
- Trial name
- NCT00194441
- Testing
- Bedside display of cerebral perfusion pressure information
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Washington
CTLA4 Haploinsufficiency
Neurologic and Immunologic Characteristics of CTLA-4 and LRBA Hereditary Deficiency
CTLA4 and LRBA deficiencies are rare genetic disorders, recently described, and associated with multiple clinical features. It ranges from recurrent infections, auto-immunity, and organ infiltration with lymphocytes.
- Trial name
- NCT05040256
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Mitochondrial Myopathies, Mitochondrial Diseases
Applying pGz in Mitochondrial Disease
This is a multi-aim study, studying the effects of conventional exercise (measured through Cardiopulomary Exercises Testing or an in-bed pedal exercise) and passive exercise through periodic acceleration (pGz).
- Trial name
- NCT05569122
- Testing
- Cardiopulmonary Exercise Testing, pGz Bed, Gentle Jogger
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Exotropia
Study of Clinical Types and Surgical Out Come of Pediatric Exotropia
study aiming to evaluate all children presented to strabismus clinic in ophthalmology department at sohag university hospital with divergent squint (exotropia) and to record surgical outcome of those who underwent strabismus…
- Trial name
- NCT05089422
- Testing
- Squint surgery
- Volunteers
- 30 people
- Sponsor
- Sohag University
Epilepsies, Partial
Added Value of Automated Electrical Source Localization (EPILOG PreOp®) to Presurgical Evaluation of Refractory Epilepsy
Drug resistant epilepsy is best managed by surgery. The goal of presurgical evalution is to correctly identify the epileptogenic zone, defined by the extent of cortical tissue that needs to be removed is order to achieve seizure…
- Trial name
- EPILOG (NCT03882151)
- Testing
- electrical source imaging
- Where
- 2 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Onchocercal Subcutaneous Nodule, Epilepsy
Onchocerciasis-Associated Epilepsy, an Explorative Case-control Study
This is an exploratory case control study with the aim to compare the Onchocerca volvulus virome between persons with onchocerciasis-associated epilepsy (OAE) and persons with onchocerciasis but without epilepsy.
- Conditions
- Onchocercal Subcutaneous Nodule, Epilepsy, Virus
- Trial name
- NCT05868551
- Testing
- nodulectomy
- Where
- South Sudan
- Volunteers
- 40 people
- Sponsor
- Universiteit Antwerpen
Cerebral Palsy (CP), Reliability and Validity
Dubousset Functional Test: An Investigation of Its Validity and Reliability in Children With GMFCS I-II Spastic Cerebral Palsy
the investigators hypothesize that over time, it may lead to loss of functional capacity in children with CP. In this context, our study aims to examine the validity and reliability of the four-component Dubousset Functional Test…
- Conditions
- Cerebral Palsy (CP), Reliability and Validity, Functional Test, Gross Motor Function Classification System (GMFCS) Level I,II
- Trial name
- NCT06831591
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Inonu University
Analgesic Adverse Reaction
Psoas Compartment Block (PCB) Versus L.A Infiltration and Remifentanil Infusion During EVAR
Endovascular aneurysm repair (EVAR) was introduced in 1990 for the first time as a minimally invasive procedure instead of the conventional open surgical repair, with the aim to decrease morbidity and mortality .
- Trial name
- NCT03443518
- Testing
- Psoas Compartment Block (PCB), Local Anesthesia infiltration, Normal saline 0.9% IV infusion
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- Dr. Erfan and Bagedo General Hospital
Cerebral Ischemia
: External Shunt Versus Internal Shunt for Off Pump Glenn
A prospective, randomized comparative study where investigators present results of off pump bidirectional Glenn operation done using either a venoatrial shunt or external shunt to decompress superior vena cava during clamping.
- Trial name
- NCT05294718
- Testing
- Internal shunt, External shunt
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Brain Injury Traumatic Mild
Using Routine Inflammatory and Metabolic Blood Tests (Bedside Included) to Predict Brain Injury in Children After Minor Head Trauma
Traumatic brain injury (TBI) poses significant strains on the paediatric population, for which the possible side effects of diagnostic imagistics could induce life-altering conditions.
- Trial name
- paeds_mTBI_Bio (NCT07397091)
- Where
- 7 sites in Romania
- Volunteers
- 800 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Motor Neuron Disease
EncoreAnywhere Use in Motor Neurone Disease
Motor neurone disease is a progressive incurable disease causing weakness and paralysis of muscles. Respiratory failure is the most common cause of death in motor neurone disease.
- Trial name
- NCT03154450
- Testing
- EncoreAnywhere with data available to review, EncoreAnywhere with no data available to review
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Fragile X Syndrome
Validation of Saliva in the Esoterix Genetic Laboratories Fragile X Assay
The purpose of this research is to determine if saliva samples can be used as an alternate sample type to test for fragile X. By using saliva instead of blood, it would be easier for patients to have fragile X testing.
- Trial name
- NCT01616589
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Esoterix Genetic Laboratories, LLC
Fibromyalgia
Prehabilitation for Being Active. A Feasibility Study in Fibromyalgia
Twelve people with FM will be recruited from the FM patient support groups. The investigators will develop and test a 4-week prehabilitation educational programme (i.e., a behavioural change intervention) consisting of meeting…
- Trial name
- NCT03764397
- Testing
- Prehabilitation for behavioural change
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Universidad de Granada
Musculoskeletal Diseases
Study on Musculoskeletal Disorders in Spanish Pianist
Background: musculoskeletal disorders related to instrumental practice (TMRPI) affect many pianists. Objectives: to know the prevalence of TMRPI in the population of Spanish pianists and its relationship with gender, age…
- Trial name
- NCT04599413
- Testing
- SURVEY
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Católica de Ávila
Cardiac Disease, Cancer
Electronic Medical Records and Genomics (eMERGE) Phase III
The Electronic Medical Records and Genomics (eMERGE) Network is in its third phase and during this time is enrolling and sequencing 25,000 individuals on a custom sequencing panel of clinically relevant, actionable genes.
- Conditions
- Cardiac Disease, Cancer, Hypercholesterolemia, Diabetes
- Trial name
- eMERGE (NCT03394859)
- Volunteers
- 25,380 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
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