Clinical trials: Neural Injury
Humeral Fractures
Management of Displaced Supracondylar Fractures of the Humerus Using Lateral vs. Crossed K-wires
Completely displaced (Type III) supracondylar fractures of the humerus are treated in the operating room and are held together with pins stuck into the bone. There are two ways of inserting the pins: crossed and laterally.
- Trial name
- NCT00358787
- Testing
- Crossed K-wiring of supracondylar fracture of the humerus, Lateral K-wiring of supracondylar fracture of the humerus
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- University of British Columbia
Hand Injuries
Cross-cultural Adaptation of the 'Cold Intolerance Severity Score' (CISS) to the Dutch Language.
To report Cold intolerance by the CISS score in medicolegal patients.
- Trial name
- Ciss-DLV (NCT05925907)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Spina Bifida, Cerebral Palsy
Assessing Transition Practices for Children With Disabilities: Pathways to a Successful Adulthood
Transition to adult care is a purposeful and structured movement of youth with complex disabilities from child centered to adult oriented services. This complex and potentially challenging period requires careful planning.
- Conditions
- Spina Bifida, Cerebral Palsy, Spinal Cord Injury, Spastic Paraplegia
- Trial name
- NCT07706517
- Testing
- Chart review, Semi-structured interview
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cerebral Palsy, Spinal Muscular Atrophy
Pediatric Powered Wheelchair Standing Devices: An Exploratory Study
For children who use a power wheelchair, a powered wheelchair standing device (PWSD) may be considered for daily use. A PWSD allows a child to electronically move between sitting and standing and can be driven in either position.
- Conditions
- Cerebral Palsy, Spinal Muscular Atrophy, Spinal Cord Injuries, Spina Bifida
- Trial name
- NCT05117827
- Testing
- Power Wheelchair Standing Device
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Tethered Cord, Tethered Cord Syndrome
Investigation of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome Patients
The investigators hypothesize that surgical release of the filum terminale (strand of fibrous tissue at the end of the spinal cord) is a more efficacious treatment option for symptomatic relief than medical management in subjects…
- Conditions
- Tethered Cord, Tethered Cord Syndrome, Occult Spina Bifida, Spina Bifida Occulta
- Trial name
- OCCULT (NCT05163899)
- Testing
- Release of filum terminale
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Spinal Cord Injuries
Spinal Cord Stimulation and Training
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of…
- Trial name
- NCT05472584
- Testing
- Electrophysiology assessment - corticospinal tract, Electrophysiology assessment - reticulospinal tract, Electrophysiology assessment - spinal motoneuron
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Neurogenic Detrusor Overactivity
Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC
The purpose of this study is to evaluate the safety, efficacy, and PK of Vibegron in pediatric participants with NDO who are regularly using CIC
- Trial name
- KANGUROO (NCT05491525)
- Testing
- Vibegron
- Where
- 38 sites in United States, Belgium and 14 more
- Volunteers
- 71 people
- Sponsor
- Urovant Sciences GmbH
Peripheral Nerve Injuries
Expanded Access - Autologous Human Schwann Cells in Peripheral Nerve Repair
Emergency expanded access for a single patient was granted to receive autologous human Schwann cell (ahSC) augmentation of nerve autograft repair after severe peripheral nerve injury (PNI).
- Trial name
- NCT04465929
- Testing
- Autologous Human Schwann Cells
- Where
- United States
- Sponsor
- W. Dalton Dietrich
Urinary Incontinence, Spinal Cord Injury
Lumbar to Sacral Ventral Nerve Re-Routing
To assess the level of improvement in voiding function after lumbar to sacral ventral nerve re-routing procedure in Spinal Cord Injury and spina bifida patients
- Conditions
- Urinary Incontinence, Spinal Cord Injury, Spina Bifida
- Trial name
- NCT00378664
- Testing
- lumbar to sacral ventral nerve re-routing procedure
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Kenneth Peters, MD
Neurosensory Function of Inferior Alveolar Nerve
Assessment of Nerve Function After Mandible Surgery With a Modified Bilateral Sagittal Split Osteotomy Technique
Several technical modifications based on the anatomical position of the neurovascular bundle and its bony mandibular canal have been developed, aiming to prevent injury to the intraalveolar nerve We hypothesized that the…
- Trial name
- NCT02634840
- Testing
- bilateral sagittal split osteotomy
- Volunteers
- 57 people
- Sponsor
- Chang Gung Memorial Hospital
Inferior Alveolar Nerve Injuries
Does Low-level Laser Therapy Protocol Affect the Efficacy of Treatment of Inferior Alveolar Nerve Injury After Maxillofacial Surgery
Dear Patient, Dear Parent / Guardian; This consent form has been prepared to enlighten you about the nature of the diagnosis and treatment methods that have been explained to you/patient and will be applied, the expected benefits…
- Trial name
- NCT06893497
- Testing
- Low Level Laser Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Karadeniz Technical University
Spina Bifida, Cerebral Palsy
Grand Valley State University (GVSU) Skills on Wheels
Manual wheelchairs (MWCs) are widely used by children with physical disabilities, yet many of these children are unable to use their wheelchair independently. Instead, they depend on others to push them.
- Conditions
- Spina Bifida, Cerebral Palsy, Genetic Disease, Spinal Cord Injuries
- Trial name
- NCT05339932
- Testing
- Manual Wheelchair Skills Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Grand Valley State University
Scapholunate Interosseous Ligament, Torn Wrist Ligaments
Biomechanical Evaluation of Wrist Ligament Injuries: Diagnostic Tool to Detect Wrist Instability
Damage to the ligaments of the wrist occurs frequently, however, it is not well publicized or understood. Our previous and current biomechanical studies have shown that damage to certain wrist ligaments is the likely cause of…
- Trial name
- NCT00657072
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Post-traumatic Stress Disorder (PTSD), Aggressive Behavior
Treatment of Trauma and Violence in the Townships of South Africa
Escalating violence is omnipresent in South African townships and can be traced back to two core mechanisms: a trauma-related hyper-arousal and a positive rewarding perception of violence.
- Trial name
- NCT02012738
- Testing
- FORNET, CBT, Waiting List Control Group (camp)
- Where
- South Africa
- Volunteers
- 45 people
- Sponsor
- University of Konstanz
Fibrolipoma of Filum Terminale, Lipomyelomeningocele
Effect of Acetazolamide & Position in CSF Leakage and Collection and Wound Dehiscence
Purpose of study : to determine the preventive effect of acetazolamide administration, prone positioning, and the combination of both following the neurosurgical interventions in lumbosacral region for cerebrospinal fluid (CSF)…
- Conditions
- Fibrolipoma of Filum Terminale, Lipomyelomeningocele, Split Cord Malformation, Dermal Sinus
- Trial name
- NCT01867268
- Testing
- Acetazolamide, prone positioning, Acetazolamide+ prone positioning
- Where
- Iran
- Volunteers
- 144 people
- Sponsor
- Tehran University of Medical Sciences
Spinal Cord Injury, Spinal Cord Involvement
Clinical Trial of a Serious Game for Individuals With SCI/D
This study will evaluate the efficacy of a newly developed serious game, SCI HARD, to enhance self-management skills, self-reported health behaviors, and quality of life among adolescents and young adults with spinal cord injury…
- Conditions
- Spinal Cord Injury, Spinal Cord Involvement, Spina Bifida, Transverse Myelitis
- Trial name
- NCT02341950
- Testing
- SCI Hard
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Michigan
Neuropathy;Peripheral, Limb Ischemia
Feasibility and Clinical Utility of Paired Non-Invasive Hemodynamic and Tissue Oximetry Monitoring to Detect Limb Ischemia in Lithotomy-Positioned Surgeries
The LIMB Study is a prospective, observational pilot study evaluating the feasibility of combined non-invasive hemodynamic and lower-limb tissue oximetry monitoring during prolonged minimally invasive pelvic surgeries performed…
- Trial name
- LIMB (NCT07387653)
- Testing
- Lower-Extremity Perfusion Monitoring
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Unilateral Vocal Cord Paralysis, Unilateral Vocal Cord Paresis
Recurrent Laryngeal Nerve Monitoring During Pediatric Aerodigestive Tract and Cardiac Surgery
This research studies whether a device used during surgery can help doctors better protect the nerve that moves a child's vocal cords. Damage to this nerve can affect speaking, swallowing, and sometimes breathing.
- Trial name
- NCT07604623
- Testing
- Intraoperative laryngeal nerve monitor
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alberta
PTSD, Adolescent
Neural Connectivity During Therapy for Adolescent PTSD
Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills.
- Conditions
- PTSD, Adolescent, Psychological Trauma
- Trial name
- NCT05423444
- Testing
- TF-CBT, TAU
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Nerve Injury, Orofacial Pain
Post-traumatic Neuropathy of the Trigeminal Nerve
This is retrospective research mainly aims to determine the patterns of symptoms, clinical and radiological findings and outcomes in patients with trigeminal neuropathy following trauma or iatrogenic damage and how this…
- Conditions
- Nerve Injury, Orofacial Pain, Trigeminal Nerve Injuries, Trigeminal Neuropathy
- Trial name
- NCT04612855
- Testing
- Groupwise comparison of primary and secondary outcomes
- Where
- Belgium
- Volunteers
- 1,333 people
- Sponsor
- KU Leuven