Clinical trials: Neurobiological
Adolescent Substance Use, Adolescent Psychological Symptoms
Parenting Mindfully Study II
This study will conduct a large Randomized Controlled Trial to test effects of a parenting mindfully (PM) intervention versus a parent education (PE) intervention for highly stressed parents of adolescents.
- Conditions
- Adolescent Substance Use, Adolescent Psychological Symptoms, Parent Stress, Parenting
- Trial name
- NCT05370768
- Testing
- Parenting Mindfully Intervention
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- George Mason University
Depression, Adolescent Behavior
Volunteering as an Intervention to Reduce Depression Among Adolescents
The purpose of the present study is to test in a preliminary manner an innovative strategy for treating depression among adolescents (alongside existing therapy) using community volunteerism.
- Conditions
- Depression, Adolescent Behavior, Depressive Symptoms
- Trial name
- NCT03816215
- Testing
- Volunteer experience
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Wake Forest University Health Sciences
Autism Spectrum Disorder (ASD)
Non-Helium Magnetoencephalography in Autism Spectrum Disorder
The goal of this observational study is to learn how brain activity in children with autism spectrum disorder (ASD) differs from typical developing children using magnetoencephalography (MEG).
- Trial name
- NCT07064967
- Testing
- Magnetoencephalography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
ADHD
Multimodal Biomarkers Predicting Medication-Induced Adverse Effects in Children With ADHD
To build a multimodal model combining neuropsychological, neurophysiological, and metabolomic measures to identify biomarkers predicting MPH-induced adverse effects and their underlying mechanisms, supporting individualized risk…
- Trial name
- NCT07900451
- Testing
- methylphenidate
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Nicotine Use Disorder, Tobacco Use Disorder
Evaluation of the Addictive Potential of E-Cigarettes
This study will examine the subject matter from a neurobiological and a neuropsychological vantage point to ascertain whether the e-cigarette is potentially as addictive as the traditional tobacco cigarette.
- Trial name
- EVAPE (NCT04772014)
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Monoamine Transporter Genes, Environmental Factors
Multimodal Neurobiological Approaches to Explore the Gene-Environment Interactions in ADHD
Previous studies have demonstrated significant associations of attention-deficit hyperactivity disorder (ADHD) with monoamine transporter genes, including dopamine transporter gene (DAT1), norepinephrine transporter gene…
- Trial name
- NCT04571125
- Where
- 2 sites in Taiwan
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Depression, Anxiety Disorders
SKY Breath Intervention
Depression is highly debilitating and prevalent among adolescents. Adolescent-onset depression is associated with long, severe, and recurrent episodes that are often not responsive to treatment.
- Trial name
- NCT05388110
- Testing
- SKY Breath Intervention
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Traumatic Brain Injury
Assessment of Noninvasive Neuromodulation in a Group of Traumatic Brain Injured Patients and Healthy Volunteers
Background: Severe traumatic brain injury, particularly diffuse axonal injury (DAI), often leads to lasting neurological issues.
- Trial name
- NCT07373366
- Testing
- Subjects in the intervention group receive low-frequency radioelectric therapy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Major Depressive Disorder
Cognitive Reappraisal in Adolescents With Major Depression
Major depression (MD) is common during adolescence and associated with significant morbidity and mortality. One important factor for the development and maintenance of adolescent MD are disturbances in emotion regulation…
- Trial name
- KONNI (NCT03957850)
- Testing
- Cognitive Reappraisal Training, Control Training
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Adolescent With Early Life Stress, Resilience
Mindfulness for Resilience in Early Life
Early life stress (ELS) is associated with a number of psychiatric and medical conditions later in life, thought to be caused by subsequent disruptions in biological processes involved in regulation of stress responses.
- Trial name
- MindREaL (NCT03633903)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Suicidal Ideation, Suicide Attempt
Neural Correlates of Suicidal Behavior in Youth
This study, titled "Neural Correlates of Suicidal Behavior in Youth: a Pre and Post CAMS Therapy Neuroimaging Study," aims to better understand the brain mechanisms underlying suicidal thoughts and behaviors in adolescents and…
- Conditions
- Suicidal Ideation, Suicide Attempt, Suicidal Behavior, Depression / Major Depressive Disorder
- Trial name
- NCT07568054
- Testing
- CAMS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Bipolar Disorder
Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder
Aim 1: Test the hypothesis that participants with Bipolar Disorder - Fear of Harm Phenotype have an enhanced amygdala fMRI response to fearful threatening stimuli, increased resting beta and gamma EEG spectral activity in…
- Trial name
- NCT05209217
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mclean Hospital
Sickle Cell Disease, Pain
Integrative Medicine in Pain Management in Sickle Cell Disease, 2.0
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.
- Conditions
- Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing
- Trial name
- NCT06725550
- Testing
- needling acupuncture, laser acupuncture
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Sickle Cell Disease, Pain
Integrative Medicine in Pain Management in Sickle Cell Disease
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupuncture analgesia in patients with sickle cell disease.
- Conditions
- Sickle Cell Disease, Pain, Acupuncture, Quantitative Sensory Testing
- Trial name
- NCT05045820
- Testing
- needling acupuncture, laser acupuncture
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Indiana University
Anorexia Nervosa, Bulimia Nervosa
Neurobiology of Eating Disorders Treatments
Background. Treatments of eating disorders result too often in partial psychological and physical remission, chronic course, dropout, relapse and death, with no fully known explanations for this failure.
- Trial name
- NEDT (NCT01990755)
- Testing
- CBT (Cognitive Behavioral Therapy), IBPP (individual psychology brief psychotherapy), CBT + OLANZAPINE
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- University of Turin, Italy
ADHD, Attention Deficit Hyperactivity Disorder
Neurobiological Basis of Response to Guanfacine Extended Release in Children and Adolescents With ADHD
This study proposes to evaluate the effects of guanfacine extended release on brain activation during fMRI in children and adolescents with ADHD between the ages 8-15 and ADHD subjects randomized to placebo treatment.
- Trial name
- NCT01709695
- Testing
- Guanfacine Hydrochloride XR
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Childhood Apraxia of Speech
Childhood Apraxia of Speech: Experience Dependent Changes Induced by Treatment
Childhood Apraxia of Speech (CAS) is a severe speech-language disorder whose aetiological, neuroanatomical correlates are largely unknown.
- Trial name
- CAS (NCT04832503)
- Testing
- PROMPT- treatment, LNSOM-treatment
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Fondazione Stella Maris
Substance Use Disorders, Adolescent Behavior
Addiction in Adolescence - Pathomechanisms and Treatment Evaluation
This study aims to investigate the sociodemographic background as well as psychiatric comorbidities of adolescent substance users with substance use disorders.
- Trial name
- MATRIX-A (NCT03444974)
- Testing
- adapted treatment according to the MATRIX-A therapy
- Where
- Germany
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Food Allergy, Food Allergy in Children
Food Allergy in the Brain
Preventing food allergic reactions predominantly relies on allergen avoidance and managing this daily causes high anxiety in some patients, while having an allergic reaction can cause a post-traumatic stress disorder-like…
- Conditions
- Food Allergy, Food Allergy in Children, Anxiety, Cognitive Symptom
- Trial name
- FAB (NCT05839405)
- Testing
- None - Cross Sectional.
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College London
Schizophrenia, Schizoaffective Disorder
Cognitive Behavioral Social Skills Training in Early Onset Psychosis
Cognitive-behavioral therapy (CBT) and social skills training (SST) are recommended psychological interventions to improve symptomatology and functional recovery in psychosis.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychosis NOS
- Trial name
- NCT03261557
- Testing
- CBT + SST, Psychoeducation, habits and healthy lifestyle
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona