Clinical trials: Neurocognition
WAGR Syndrome, Wilm's Tumor
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions
This study will explore conditions caused by the absence of certain genes on chromosome 11. These conditions include WAGR syndrome, which is characterized by a kidney tumor called Wilm s tumor, aniridia (absence of the iris of…
- Conditions
- WAGR Syndrome, Wilm's Tumor, Aniridia, Urogenital Abnormalities
- Trial name
- NCT00758108
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Severe Acute Malnutrition in Childhood, Malnutrition, Child
Treatment of Severe Acute Malnutrition in Children 6 to 59 Months Old With Standard Ready To Use Therapeutic Food Compared to a Newly Formulated Lipid Optimized Ready To Use Therapeutic Food
The goal of this randomized clinical trial is to learn if a newly formulated Lipid-Optimized Ready-to-Use Therapeutic Food (LO-RUTF) can treat severe acute malnutrition in children aged 6 to 59 months.
- Conditions
- Severe Acute Malnutrition in Childhood, Malnutrition, Child, Neurocognition, Child
- Trial name
- NCT07345884
- Testing
- Lipid-Optimized Ready to Use Therapeutic Food (RUTF), Ready to Use Therapeutic Food (RUTF)
- Where
- Pakistan
- Volunteers
- 125 people
- Sponsor
- University of California, Los Angeles
PTEN Gene Mutation, PTEN Hamartoma Tumor Syndrome
RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome
Phosphatase and TENsin homolog (PTEN) gene germline mutations are associated with a spectrum of clinical manifestations characterized by neurocognitive deficits, intellectual disability, autism symptomatology, skin lesions…
- Trial name
- NCT02991807
- Testing
- RAD001
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- Boston Children's Hospital
Diabetes Mellitus
Diabetic Ketoacidosis and Its Impact on the Brain
About the Study: This research study is being conducted to see if diabetic ketoacidosis has any impact on learning, behavior and development in children with Type 1 diabetes mellitus.
- Trial name
- NCT01753934
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Attention Deficit Hyperactivity Disorder
Sleep Dysfunction and Neurocognitive Outcomes in Adolescent ADHD
This study seeks to characterize sleep physiology in adolescents with and without Attention deficit hyperactivity disorder (ADHD) and its relationship to differential neurocognitive and clinical outcomes within these groups.
- Trial name
- NCT02897362
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Duke University
Structural Racism, Substance Use Risk
Structural Racism, Reward Related Decision Making and Substance Use Risk
The goal of this observational study, which has a pilot phase (R61) and a second, larger phase (R33), is to learn about the impact of indicators of structural racism (SR) on substance use risk in Puerto Rican adolescents living…
- Trial name
- NCT06221839
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Columbia University
Traumatic Brain Injury
TBI Project Amsterdam
Traumatic Brain Injury (TBI) is the world leading cause of acquired brain injury. Literature suggests a pivotal role for attentional functioning in neurocognitive and behavioural consequences of paediatric TBI.
- Trial name
- NCT01720979
- Where
- 5 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Marsh Königs
Aggression, Antisocial Behavior
Omega-3 Supplementation and Behavior Problems
The objectives of this project are as follows: 1. To assess whether omega-3 dietary supplementation for six months can reduce externalizing behavior problems (antisocial and aggressive behavior) in schoolchildren aged 8 to 18…
- Conditions
- Aggression, Antisocial Behavior, Antisocial Personality
- Trial name
- NCT02334098
- Testing
- Omega-3 supplemented drink, Smartfish
- Where
- China
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Dr. Annis Fung
Eating Disorder
Impact of Neuropsychological Alteration of Patients With Eating Disorders
Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking.
- Trial name
- NeuropsyTCA (NCT04091477)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Sickle Cell Disease
Peripheral Arterial Tonometry and Neurocognition in Sickle Cell Disease
This study will examine sleep disordered breathing and sleep quality in participants (ages 12-25) diagnosed with sickle cell disease of any genotype.
- Trial name
- NCT06477289
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- St. Jude Children's Research Hospital
Sickle Cell Disease, Cognitive Ability, General
Improving Parental Psychosocial Functioning and Early Developmental Outcomes in Children With Sickle Cell Disease
There are all significant risk factors for poor early cognitive development and, as such, neurocognitive deficits have been demonstrated in pre-school children with sickle cell disease (SCD).
- Conditions
- Sickle Cell Disease, Cognitive Ability, General, Psychological Stress, Parenting
- Trial name
- NCT02394899
- Testing
- Play therapy, Problem solving skills
- Where
- Jamaica
- Volunteers
- 64 people
- Sponsor
- The University of The West Indies
Pediatric Obesity, Binge-Eating Disorder
Project THINK: Trajectories of Health, Ingestive Behaviors, and Neurocognition in Kids
Overweight/obesity and loss of control eating (characterized by the sense that one cannot control what or how much one is eating) are prevalent among children and adolescents, and both are associated with serious medical and…
- Trial name
- NCT04701671
- Testing
- Observational (not including MRI scanning), Observational (including MRI scanning)
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Sickle Cell Disease, Sickle Cell
Objective Neurocognitive Assessment of Young Children With Sickle Cell Disease by Eye-Tracking
Evidence indicates that Sickle Cell Disease (SCD) threatens neurodevelopmental outcome. Although children with SCD may be heterogeneously affected, neurocognitive impairment may already be present in toddlers.
- Conditions
- Sickle Cell Disease, Sickle Cell, Neurocognition, Child
- Trial name
- ONSET (NCT07721155)
- Testing
- eyetracking, blood work, Strengths and difficulties questionnaire (SDQ)
- Where
- Netherlands
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Depression
Effects of Aerobic Exercise Intensity on Clinical & Neural Outcomes in Depressed Youth
This study will assess the effects of moderate vs. high intensity aerobic exercise, performed 3 times a week for 12 weeks under supervised conditions, on symptoms of depression, cognitive functioning and brain function in…
- Trial name
- NCT04110041
- Testing
- Aerobic Exercise
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Royal's Institute of Mental Health Research
Obstructive Sleep Apnea Syndrome
Cerebral Blood Flow and Childhood Obstructive Sleep Apnea
Obstructive sleep apnea syndrome (OSAS) causes hypoxemia and hypercapnia, which may impair cerebral blood flow and cause deficits in behavior.
- Trial name
- NCT02995837
- Testing
- Sleep Study, Neurocognitive Testing, CBF During Wakefulness
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Premature Baby, Neurocognition, Child
Longitudinal Assessment of Early Premature Infant Skills for Audiovisual Speech Perception
From birth, babies perceive speech face to face with their interlocutors in audiovisual situations (AV): in addition to hearing them (auditory speech), they will also, in most cases, be able to observe their speaking faces (ex…
- Trial name
- Pré-AV (NCT07245693)
- Testing
- Audiovisual association capability tests
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Behavioral Addiction
Behavioral Addictions and Related NeuroCOgnitive Aspects
Improving knowledge about behavioural addictions is a real public health issue. The etiopathogenic model of behavioural addictions is multifactorial, with various risk and vulnerability factors, involved in the initiation and…
- Trial name
- BANCO2 (NCT03967418)
- Testing
- Cognitive and clinical assessment
- Where
- France
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Bipolar Disorder (BD)
Psychoeducational Psychotherapy in Adolescent Bipolar Disorder
This study evaluated the effects of psychoeducational psychotherapy (PEP) on neurocognitive functions, symptomatology, quality of life, and emotion regulation in euthymic adolescents with bipolar disorder (BD).
- Trial name
- NCT07396363
- Testing
- Psychoeducational psychotherapy (PEP)
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Dokuz Eylul University
Attention Deficit Hyperactivity Disorder
Added Value of the Oculomotor and Cognitive Examination in the Management of Patients With ADHD
ADHD is a neurodevelopmental disorder characterized by symptoms of inattention and / or hyperactivity-impulsivity that affects nearly 6% of school-aged children and persists into adulthood.
- Trial name
- NCT03411434
- Testing
- Methylphenidate Oral Tablet
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Rouffach
Behavior, Child, Neurocognition, Child
Community-Based Conscious Discipline Program in Grenada
To improve neurocognitive outcomes in 2-year-old children by implementing a community-based intervention program that follows the principles of Conscious Discipline.
- Conditions
- Behavior, Child, Neurocognition, Child, Development, Child
- Trial name
- NCT04697134
- Testing
- Conscious Discipline-Based Environmental Enrichment Intervention
- Where
- Grenada
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- Windward Islands Research and Education Foundation