Clinical trials: Neurodevelopmental Disability
Education
Effectiveness of an Early Reading Intervention for Young Children With Intellectual Disabilities Who Need or Use Augmentative and Alternative Communication
The goal of this 2x2 factorial randomized controlled trial is to evaluate the effectiveness of two literacy interventions delivered at different time points, in kindergarten and in first grade, on the development of literacy…
- Trial name
- NCT07116200
- Testing
- Early Literacy Intervention in Kindergarten, Literacy Intervention in First Grade
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Ostfold University College
Dyslexia, Dance Therapy
The Effects of Creative Dance Therapy on Motor and Executive Functions in Children With Dyslexia
Although some benefits of dance have been described for motor and cognitive skills, the effects on individuals with dyslexia are unclear.
- Conditions
- Dyslexia, Dance Therapy, Motor Skills, Executive Function
- Trial name
- NCT05850169
- Testing
- Creative Dance Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Ankara Medipol University
Developmental Dyslexia
Brain Stimulation With Combined Reading and Motor Training for Children With Dyslexia
This study examines whether combining non-invasive brain stimulation (tDCS) with an integrated reading-and-motor training program improves reading and phonological processing in 9-year-old boys with developmental dyslexia.
- Trial name
- NCT07781761
- Testing
- Active transcranial direct current stimulation (tDCS), Phonological awareness training, Non-targeted fine motor training
- Where
- Iran
- Volunteers
- 160 people
- Sponsor
- Shahid Beheshti University
Intellectual Disabilities Nutritional, Intellectual Disability
Dietary Intervention and Adults With Intellectual Disabilities
Goal The overall aim of the study is to improve the health of persons with Intellectual disabilities
- Trial name
- NCT04436692
- Testing
- Nudging
- Where
- Norway
- Volunteers
- 32 people
- Sponsor
- University of Oslo
Developmental Dyslexia, Reading Problem
Personalization of Visual Characters and Text-to-Speech (TTS) to Support Learning in Students With Reading Difficulties
Previous research has shown the importance of font type, size and spacing to facilitate text reading in dyslexia. A special automatized procedure was designed to select the most favorable parameters for both text visualization…
- Trial name
- NCT06947512
- Testing
- Seleggo Test
- Where
- 3 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Typical Development, Risk of Dysgraphia
Graphomotor Intervention Program for Handwriting Difficulties Prevention in School-Age
12-30% of children present handwriting difficulties, which has negative repercussions on their school career. For this reason, it is fundamental to bet on their prevention.
- Conditions
- Typical Development, Risk of Dysgraphia, Dysgraphia
- Trial name
- NCT03699800
- Testing
- Graphomotor intervention program
- Where
- Portugal
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Évora
Developmental Disabilities
Child Development and Genetic Biomarkers(II): Gene Verification and Data Integration
The aims of the study include (1) identifying genes associated with child development and developmental delay in Taiwan (2) comparing the differences and similarities between genetic biomarkers of development and developmental…
- Trial name
- NCT06532721
- Where
- Taiwan
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Autistic Disorder
Proteomic Biomarker Tests in Blood Samples from Children with Autism Spectrum Disorder (ASD)
Behavioral testing is the gold standard for diagnosing autism spectrum disorder (ASD). These tests, including ADOS and ADI-R, are subjective, require trained staff to administer, are time-consuming, and can only be administered…
- Trial name
- NCT02168868
- Testing
- Blood draw, Stool Sample Collection, Urine Sample Collection
- Where
- Israel
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Benjamin Gesundheit
Doose Syndrome, Epileptic Syndromes
The Becoming of Children With Doose Syndrome
Doose syndrome is a rare epileptic syndrome that can lead to learning difficulties and a poor quality of life. The goal of this study is to evaluate the evolution of epilepsy and its consequences on cognitive development and…
- Conditions
- Doose Syndrome, Epileptic Syndromes, Learning Disabilities
- Trial name
- DOOSE (NCT04048213)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Developmental Disabilities
ACT Dad's Power: Feasibility RCT for Fathers of Children With Special Needs
Objective: (1) To examine the feasibility of proceeding to a future definitive RCT of ACT in Hong Kong Chinese fathers rearing children with special needs.
- Trial name
- NCT07459010
- Testing
- VR-based ACT, Health Talks and Simple Social Support
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Lungs; Developmental Disorder
Use of Hyperpolarized 129Xe MR Lung Imaging in Infants
Abnormalities of the lungs are common in newborns and can include aspiration or infectious pneumonia, respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), pulmonary hypertension (PH), congenital diaphragmatic…
- Trial name
- NCT04995562
- Testing
- 129Xe
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Neurodevelopmental Cognitive, Motor and Speech-language Disabilities
Assessment and Telerehabilitation of Cognitive and Motor Skills in Children With Neurodevelopmental Disabilities (Tablet Project)
The development and application of new technologies to support functional assessment and rehabilitation pathways for neurodevelopmental disabilities allow the evaluation and enhancement of cognitive, motor, and speech abilities…
- Trial name
- NCT06290297
- Testing
- Telerehabilitation VRRS
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- IRCCS Fondazione Stella Maris
Developmental Dysphasia, Epileptic Encephalopathy, Childhood-Onset
CNKSR2 Natural History Study
This prospective natural history study is being conducted to define the electroclinical, neurodevelopmental, and behavioral characteristics of CNKSR2 epilepsy aphasia syndrome (EAS) and intellectual disability (ID) in children…
- Conditions
- Developmental Dysphasia, Epileptic Encephalopathy, Childhood-Onset, X-Linked Intellectual Disability
- Trial name
- CNKSR2 (NCT06500260)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Neurodegenerative Disease
Cause and Pathogenesis of Neurometabolic Disorders
This study will examine the origin and development of certain neurological diseases involving abnormal metabolism. A significant number of patients with progressive neurological disorders have not been diagnosed despite extensive…
- Trial name
- NCT00016562
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Autism Spectrum Disorder, Developmental Delay
Validation of a Salivary miRNA Diagnostic Test for ASD
This study involves sample collection to identify biomarkers relating to Autism Spectrum Disorder(ASD) in the saliva of children who are between the ages of 18 months to 6 years and 11 months.
- Trial name
- NCT05418023
- Testing
- Salivary Collection, Adaptive Assessment, Medical and Demographic questionnaire
- Where
- 16 sites in United States
- Volunteers
- 6,604 people
- Sponsor
- Quadrant Biosciences Inc.
Developmental Disorders
Risk of Recurrence of de Novo Mutations: Research and Quantification of Paternal Germinal Mosaicism by the Combined Use of Genomic Tools
1. Inclusion of 5 families Inclusions will be made by the clinical genetics department of the Rouen University Hospital (monocentric study) and will correspond to trios of parents + child with unexplained developmental…
- Trial name
- RRMUT (NCT04564235)
- Testing
- genome-wide analyses, Search for de novo mutations in paternal sperm samples
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Autism Spectrum Disorder, Intellectual Disability
Heart Rate Informed Changes in Care for Non-Communicating Patients
The overarching aim is to generate knowledge to reduce incidence of pain in non-verbal patients' everyday life. The trial will 1) evaluate how HR can be used to identify potentially painful care procedures that should be…
- Conditions
- Autism Spectrum Disorder, Intellectual Disability, Communication, Nonverbal
- Trial name
- NCT05738278
- Testing
- HR-informed change in routine, Delayed HR-informed specific change in routine
- Where
- 2 sites in Norway
- Volunteers
- 38 people
- Sponsor
- University of Oslo
Mental Retardation
Effects of Different Dual-Task Exercises in Children With Mild Mental Retardation
The purpose of this study is to investigate the effects of motor-motor and motor-cognitive dual-task exercises applied to children with mild mental retardation on their functional mobility, balance, cognitive function, and…
- Trial name
- NCT07028333
- Testing
- Motor-Motor Dual Task Exercise Group, Motor-Cognitive Dual Task Exercise Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Istanbul University - Cerrahpasa
Intellectual Disability
Equine Therapy Programme on Stress, Autonomy and Balance in School-age Children With Intellectual Disabilities
The aim of this study is to determine the impact of an equine therapy programme on the emotional state and autonomy of school-aged individuals with intellectual disabilities.
- Trial name
- NCT07497035
- Testing
- EQUINE THERAPY
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Universidad Pontificia Comillas
Heathly Subjects Susceptible to SARS-CoV-2 Infection
Microbiome-Based Risk Prediction of SARS-CoV-2 in Children and Families (PREDICOL)
The goal of this observational cohort study is to evaluate the association between gut microbiota composition, dietary patterns, lifestyle-related factors, and neurodevelopmental outcomes, as well as susceptibility to SARS-CoV-2…
- Trial name
- PREDICOL (NCT07717008)
- Where
- Spain
- Volunteers
- 932 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council