Clinical trials: Neurodevelopmental Disorders
Autism Spectrum Disorder, Fra(X) Syndrome
Establishing a Diagnostic and Therapeutic Index in Autism Spectrum Disorder (ASD) and Fragile X Syndrome
The purpose of this study is to accumulate and quantitatively analyze data on the microbiome, serotonin signaling and genetics, and inflammatory cytokines from patients with Autism Spectrum Disorder and Fragile X Syndrome.
- Trial name
- NCT04869930
- Testing
- specimen collection
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nova Mentis Life Science Corp
Autism Spectrum Disorder, Developmental Delay
MAP Autism Prediction Study
This pilot clinical trial tests the hypothesis that certain blood metabolite levels can be used to predict Autism Spectrum Disorder (ASD).
- Trial name
- MAP (NCT04672967)
- Testing
- BioROSA MAP test
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- BioROSA Technologies Inc
Attention Deficit Hyperactivity Disorder
Magnetic Resonance Imaging of Brain Development in Attention Deficit Hyperactivity Disorder
The primary purpose of this study is to investigate brain whether ADHD represents a disruption or a delay of brain development. Children and adolescents both with and without ADHD are asked to participate in several MRI sessions…
- Trial name
- NCT00143767
- Where
- Netherlands
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Attention Deficit Hyperactivity Disorder
ADHD/Me Bibliotherapy Study
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood. It affects approximately 8% of school aged children and is characterized by persistent symptoms of inattention…
- Trial name
- NCT03620344
- Testing
- ADH-Me Book and ADHD Informational Brochure, ADHD Informational Brochure Only
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Developmental Disabilities
Child Development and Genetic Biomarkers(II): Gene Verification and Data Integration
The aims of the study include (1) identifying genes associated with child development and developmental delay in Taiwan (2) comparing the differences and similarities between genetic biomarkers of development and developmental…
- Trial name
- NCT06532721
- Where
- Taiwan
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Autism Spectrum Disorder
Investigation of the HDAC4 Copy Number Variation and Its Effect on Gene and Protein Expression in Patients With ASD
Specific Aims of this study: 1. To understand the distribution of HDAC4 CNV in the families of the ASD patients with HDAC4 CNV; 2. To perform the analysis of gene expression; 3.
- Trial name
- NCT03670381
- Testing
- Psychiatric diagnosis
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Child Development Disorders, Pervasive
A Prospective Study Comparing the Mifne Approach of Treating Childhood Autism With Routine Standard Treatment
The current study aims at comparing outcomes achieved using the Mifne approach of treating autistic children with results obtained when routine standard treatment is used.
- Trial name
- NCT00445471
- Testing
- Mifne Approach to PDD, Treatment as usual
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Rabin Medical Center
Autistic Disorder
Characterisation of Circadian Rhythm in Autistic Spectrum Disorder
Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions characterized by deficits in social communication, delay in language and repetitive behaviors.
- Trial name
- NCT01984944
- Testing
- Autistic functional exploration, Control functional exploration
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder
OPT-IN: Online Parent Training Intervention for Young Children Diagnosed With Autism Spectrum Disorder
The goal of this observer-blinded randomized controlled clinical trial is to determine the effectiveness of a fully-online, parent-mediated, video-based, self-directed intervention for young children with autism (12-60 months)…
- Trial name
- NCT06011707
- Testing
- OPT-IN, Psychoeducational control
- Volunteers
- 308 people
- Sponsor
- Elizabeth Kelley
Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia
Natural History Study of Patients with HPDL Mutations
This study uses medical records that allow retrospective data extraction of clinical manifestation to assess the natural history of HPDL mutations
- Conditions
- Mitochondrial Encephalomyopathies, Hereditary Spastic Paraplegia, Spastic Paraplegia, White Matter Disease
- Trial name
- NCT05848271
- Testing
- Patient Registry, Dry blood spots sampling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Autism Spectrum Disorder
A Virtual Dental Office Experience for Children With Autism Spectrum Disorder
The objective of this study is to evaluate the effectiveness of virtual reality (360° video) compared to a social story for reducing pre-visit dental anxiety for children with autism spectrum disorder (ASD) improve the dental…
- Trial name
- NCT05196230
- Testing
- Control Condition (Social Story), Experimental Condition (360° Video)
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Autism Spectrum Disorder
Effectiveness of a Parent-mediated Intervention With PACT on Children With ASD
Autism Spectrum Disorder (ASD) is a neuro-developmental disorders. There are different types of interventions. Among these interventions Early Start Denver Model (ESDM) and Preschool Autism Communication Therapy (PACT) have…
- Trial name
- IFPAD (NCT04244721)
- Testing
- Preschool Autism Communication Therapy (PACT), Treatment As Usual (TAU)
- Where
- France
- Volunteers
- 212 people
- Sponsor
- Hôpital le Vinatier
Autism Spectrum Disorder
Treatment by Therapeutic Body Wraps in Children and Adolescents Suffering From Autism With Severe Injurious Behavior.
Severe injurious behaviors in children with autism spectrum disorder are challenging. First line treatment approaches include behavioral techniques but pharmacotherapy is frequently required despite frequent adverse effects in…
- Trial name
- PACKING (NCT03164746)
- Testing
- Dry sheet Therapeutic body wraps, WET sheet Therapeutic body wraps
- Where
- 13 sites in France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Attention-deficit/Hyperactivity Disorder
A Genome-wide Association Study on the Endophenotype of Spatial Working Memory in ADHD
Specific Aims: 1. To find the genetic variations associated with spatial working memory performance in patients with ADHD by using genome-wide association studies (GWAS); 2.
- Trial name
- NCT02710929
- Where
- Taiwan
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Neurocognitive Impairment, Acute Lymphoblastic Leukemia
Risk of Psychopathology and Neurocognitive Impairment in Leukemia Survivors
1. This study will evaluate the association between changes in basic cognitive and behavioral functioning by the end of chemotherapy treatment, and the later development of higher order executive functions in pediatric acute…
- Trial name
- NCT01014195
- Testing
- Neurocognitive and behavioral evaluation
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- St. Jude Children's Research Hospital
Attention Deficit Disorder With Hyperactivity (ADHD), Autism Spectrum Disorder (ASD)
External Trigeminal Nerve Stimulation for Children With ASD + ADHD to Reduce Elevated Symptoms
The goal of this clinical trial is to learn if external trigeminal nerve stimulation (eTNS) works to treat ADHD symptoms in children on the autism spectrum (ASD).
- Trial name
- eTNS CARES (NCT07214545)
- Testing
- Trigeminal Nerve Stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Anxiety, Obsessive-Compulsive Disorder
Virtual Reality System for Anxiety and OCD
Cognitive Behavioral Therapy with fear provoking exposures is the most effective therapy for anxiety disorders. The investigators aim to enhance this therapy with the use of virtual reality exposures.
- Trial name
- NCT03636022
- Testing
- VR System, Control
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Minnesota HealthSolutions
Autism Spectrum Disorder, Speech
Thinking in Speech for Children With Autism
This study examines a cognitive therapy for autistic children, Thinking in Speech. Thinking in Speech helps children with autism independently cope with everyday events that cause stress, by developing their ability to use "inner…
- Trial name
- NCT05256095
- Testing
- Thinking in Speech
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pittsburgh
Tic-Disorder
Efficacy of a Habit Reversal Treatment on Tic-symptoms
The main purpose of this study is to evaluate the efficacy of a habit reversal based treatment programme in children and adolescents aged 8 to 18 years with tic disorders.
- Trial name
- NCT02190383
- Testing
- Habit Reversal Training
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Tuberous Sclerosis Complex
Studies in Patients With Tuberous Sclerosis Complex
This study is aimed to carry out a systematic study to examine the effects of genetic variants (genetic modifiers) other than TSC genes on phenotypic variability in familial TSC patients (affected parent, child and unaffected…
- Trial name
- NCT03276195
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Translational Genomics Research Institute
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