Clinical trials: Neurodevelopmental Disorders
Developmental and Epileptic Encephalopathy
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
This (DEEp OLE Study) is a multicentre, open-label study to investigate the long-term safety, efficacy, tolerability, and pharmacokinetics (PK) of LP352 in the treatment of seizures in children and adults with DEE who completed…
- Trial name
- NCT06908226
- Testing
- LP352
- Where
- 88 sites in United States, Australia and 15 more
- Volunteers
- 324 people
- Sponsor
- Longboard Pharmaceuticals
ADHD or ADHD Traits
Development and Evaluation of a Digital Game Intervention Targeting Children Vulnerable to ADHD
The goal of this clinical trial is to learn whether a self-administered digital game can improve attention, memory, and planning and reduce ADHD-like symptoms in children aged 6-12 in Hong Kong who have subclinical or vulnerable…
- Trial name
- NCT07900048
- Testing
- Digital Game Intervention, Tetris
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
ADHD; Resilience; Stress
Comparison of Resilience Between ADHD and Controls.
To explore if resilience serves as a mediator between adverse life events and emotional and behavioral problems, and compare the difference of resilience and its mediating effects between children and adolescents with and without…
- Trial name
- NCT05620745
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Chang Gung Memorial Hospital
Preterm Infant, Umbilical Cord Milking
Effect of Intact Umbilical Cord Milking on Neonatal and First Year Neurodevelopmental Outcomes in Very Preterm Infants.
The investigators hypothesise that intact umbilical cord milking (I-UCM) will reduce neonatal morbidity and improve long term neurodevelopmental outcome in very preterm infants.
- Trial name
- Cord-milking (NCT03200301)
- Testing
- Intact Umbilical Cord Milking
- Where
- India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jubilee Mission Medical College and Research Institute
Autism Spectrum Disorder
Comparative Efficacy of Self-directed & Therapist-assisted Telehealth Parent Training Intervention for Children With ASD
The specific objectives of this project are to conduct a randomized control trial to examine the effect of a novel, telehealth parent training intervention for children with autism spectrum disorder (ASD), ImPACT Online, on…
- Trial name
- NCT02721381
- Testing
- ImPACT Online
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Michigan State University
Intellectual Disability
Development and Application-Smart Football for Movement Evaluation and Training in the Special Education Population
Children with disabilities are frequently ignored by the general population, hence the development of movement evaluation and training devices for use in special education settings are relatively overlooked.
- Trial name
- NCT02486081
- Testing
- smart soccer ball
- Where
- 2 sites in Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Attention Deficit Hyperactivity Disorder
Efficacy, Safety, and Tolerability of Ambien (Zolpidem) in the Treatment of Children Ages 6 to 17 With Attention Deficit Hyperactivity Disorder (ADHD)-Associated Insomnia
There has been an increased interest in the association between ADHD and sleep disorders over the past years. A high incidence of sleep disturbance, ranging from 10% to 70%, has been identified in ADHD children regardless of…
- Trial name
- Zolkids (NCT00318448)
- Testing
- Zolpidem (SL800750)
- Where
- 2 sites in United States, Canada
- Volunteers
- 201 people
- Sponsor
- Sanofi
Neurodevelopmental Disorders
Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder
The purpose of this study is to evaluate the efficacy of a novel positive emotion regulation intervention that aims to increase positive emotions and improve emotion regulation skills in children, adolescents and young adults.
- Trial name
- ERICA (NCT02898298)
- Testing
- Positive Emotion Regulation Training
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Autism Spectrum Disorder (ASD), Intellectual Disability
Emotion Intensity Modulates Intention in ASD
This study used eye-tracking to examine how emotional expression intensity (low/medium/high) influences intention understanding in children with ASD, PDD, and TD during a puzzle-search task.
- Trial name
- NCT07597655
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Attention Deficit Hyperactivity Disorder
Cardiovascular Safety of Atomoxetine in Children With ADHD
This prospective observational cohort study aims to evaluate the cardiovascular safety of atomoxetine therapy in children with attention-deficit/hyperactivity disorder during the first six months of treatment.
- Trial name
- NCT07858448
- Volunteers
- 82 people
- Sponsor
- Assiut University
Substance Use, Conduct Disorder
A Family Intervention for Adolescent Problem Behavior (AKA Project Alliance 2)
The goal of this project is to empirically refine and improve a comprehensive family-centered prevention strategy for reducing and preventing adolescent substance use and other problem behaviors.
- Conditions
- Substance Use, Conduct Disorder, Depression, Anxiety
- Trial name
- PAL-2 (NCT01490307)
- Testing
- Family Check-Up
- Where
- United States
- Volunteers
- 593 people
- Sponsor
- University of Oregon
Insomnia
Parent-Mediated Telehealth Intervention for Insomnia in Young Autistic Children
This study will evaluate the efficacy of a structured parent-mediated behavioral intervention called Sleep Parent Treatment (SPT) for insomnia in autistic children ages 3 to 7 years 11 months, compared to another behavioral…
- Trial name
- NCT07435740
- Testing
- Sleep Parent Training (SPT), Sleep Parent Education (SPE)
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- The Cleveland Clinic
Attention Deficit Hyperactivity Disorder
Neurocognitive Exercise Program for Children With Attention Deficit and Hyperactivity Disorder
The effects of Neurocognitive Exercise Program (NEP) on ADHD symptoms and executive functions in children with Attention Deficit and Hyperactivity Disorder (ADHD) will be investigated using The Conners parent rating scale-revised…
- Trial name
- NCT04707040
- Testing
- Neurocognitive Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Autistic Spectrum Disorder
Umbilical Cord Blood vs Personalized Treatments for Improving Autistic Disorder
The clinical study evaluates in an open-label, crossover design the comparative efficacy and safety of intranasal oxytocin and autologous umbilical cord blood for improving the functioning of children with autistic spectrum…
- Trial name
- NCT04007224
- Testing
- Intranasal oxytocin, Autologous umbilical cord blood
- Where
- 2 sites in Romania
- Volunteers
- 35 people
- Sponsor
- Fundatia Bio-Forum
Conduct Disorder, ADHD
Investigation of Psychophysiological Response to Aversive Stimuli Over Time With Omega-3
This study investigates the psychophysiological responses to aversive stimuli in a population of 133 children clinically diagnosed with conduct disorder (CD) and/or attention-deficit/hyperactivity disorder (ADHD).
- Conditions
- Conduct Disorder, ADHD, Oppositional Defiant Disorder
- Trial name
- NCT03749824
- Testing
- Omega-3
- Volunteers
- 133 people
- Sponsor
- Yale-NUS College
Attention Deficit Hyperactivity Disorder (ADHD)
Crossover Study to Evaluate the Efficacy of AR11 in Pediatric Patients With ADHD in a Laboratory Classroom Setting
This is a dose-optimized, randomized, double-blind, placebo-controlled crossover study in approximately 100 pediatric patients (aged 6 to 12 years) with ADHD.
- Trial name
- NCT01986062
- Testing
- AR11
- Where
- 7 sites in United States
- Volunteers
- 97 people
- Sponsor
- Arbor Pharmaceuticals, Inc.
Autism
Show Me to Help Me
This cohort observation, randomized controlled trial is intended to provide data that icons and non-verbal communication improve communication and cooperation with children with Autism/communication delay and aid in the…
- Trial name
- NCT01311596
- Testing
- Icons
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Akron Children's Hospital
Autism Disorder, Autism Spectrum Disorder (ASD
Effectiveness of Interactive Techniques on Oral Hygiene Skills in a Group of Autistic Egyptian Children
The present study will be performed to evaluate the effectiveness of peer modeling and audiovisual peer modeling video on toothbrushing skills in comparison to the visual pedagogical method at home.
- Conditions
- Autism Disorder, Autism Spectrum Disorder (ASD, Autism, Plaque Reduction
- Trial name
- Autism ASD (NCT07859696)
- Testing
- Peer model, Pre-recorded video of peer modeling, Pedagogical method
- Volunteers
- 90 people
- Sponsor
- Faculty of Dental Medicine for Girls
Attention Deficit Hyperactivity Disorder, Deficient Emotional Self-Regulation
Omega-3 Supplementation to ADHD Medication in Children
This study is a 12-week open-label trial to assess the effectiveness of Omega-3 fatty acids for deficient emotional self-regulation (DESR) as a supplement to Attention Deficit/Hyperactivity Disorder (ADHD) treatment in children…
- Trial name
- NCT02204410
- Testing
- Omega-3 Fatty Acid, ADHD Medication
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Attention Deficit Hyperactivity Disorder Symptoms
Study of the Collaborative Life Skills Program
This study tests the effectiveness of a newly developed integrated school-home behavioral intervention for behaviors related to Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT01686724
- Testing
- Collaborative Life Skills Intervention (CLS), Business As Usual
- Where
- United States
- Volunteers
- 504 people
- Sponsor
- University of California, San Francisco
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