Clinical trials: Neuroimaging
Electroencephalography, Refractory Epilepsy
Clinical Utility of ESI in Presurgical Evaluation of Patients With Epilepsy
This study evaluates to what extend electrical source imaging (ESI) provides nonredundant information in the evaluation of epilepsy surgery candidates.
- Conditions
- Electroencephalography, Refractory Epilepsy, Brain Imaging, Surgery
- Trial name
- CUESIPE (NCT03533530)
- Testing
- Low-density ESI (LD ESI), High-density ESI (HD ESI), No electrical source imaging (ESI)
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pollution; Exposure, Neurodevelopmental Disorders
Air Pollution and Development in the Boricua Youth Study
This study seeks to understand the relationship between prenatal maternal air pollution exposure and offspring risk for ADHD and examine two potential -modifiable- mechanisms: prenatal maternal inflammation and offspring sleep…
- Trial name
- NCT05368493
- Testing
- MRI task
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Motor Skills Disorders, Premature Birth
Premie DCD Imaging Intervention Study
This study will leverage a current longitudinal study of brain development in preterm children. In the Miller/Grunau Trajectories study, preterm children are returning for follow-up at 8-9 years.
- Trial name
- NCT04483401
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Head Injury, Traumatic Brain Injury
Selective CT for Anticoagulated Head Injured Patients
The goal is to derive and a clinical decision rule for safe exclusion of traumatic brain injury without neuroimaging in head-injured ED patients who take anticoagulant medications. The objectives are to: 1.
- Conditions
- Head Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Traumatic, Blunt Head Injury
- Trial name
- Can-SCAHn (NCT05364749)
- Where
- 7 sites in Canada
- Volunteers
- 4,000 people
- Sponsor
- Dr. Kerstin de Wit
Cerebral Decompression Illness, All Phases
Hyperbaric Oxygen Therapy and SPECT Brain Imaging in Cerebral Decompression Illness
Chart review of patients who received hyperbaric oxygen therapy for cerebral decompression illness who also underwent SPECT brain blood flow imaging to see if SPECT brain imaging tracks and is consistent with the clinical…
- Trial name
- NCT02105194
- Testing
- Hyperbaric oxygen therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Paul G. Harch, M.D.
Childhood Schizophrenia, Psychotic Disorder
Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders
The purpose of this study is to compare the effectiveness and side effects of the drugs clozapine and olanzapine in children and adolescents with schizophrenia and psychoses.
- Conditions
- Childhood Schizophrenia, Psychotic Disorder, Schizophrenia
- Trial name
- NCT00001656
- Testing
- Olanzapine, Clozapine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Mental Health (NIMH)
Autism Spectrum Disorder
Behavioral and Neural Response to Memantine in Adolescents With Autism Spectrum Disorder
This study is a 12-week, randomized-controlled trial of memantine hydrochloride (Namenda) for the treatment of social impairment in adolescents with autism spectrum disorder (ASD).
- Trial name
- NCT01972074
- Testing
- Memantine
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
Magnetic Resonance Imaging of the Brain in Social and Emotional Reasoning
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in social and emotional reasoning. It will identify differences in brain activity during task performance between people who have a nervous…
- Trial name
- NCT00060853
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Intracerebral Hemorrhage
Retrospective Study of Intracerebral Hemorrhage Patients in Hospital Parc Taulí
This is a retrospective observational study to investigate the clinical, analytical and neuroimaging data generated during routine clinical management of intracerebral hemorrhage.
- Trial name
- NCT04877405
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 137 people
- Sponsor
- Universitat Autonoma de Barcelona
Developmental Coordination Disorder
Does tDCS Improve Motor Learning in Children With DCD?
Transcrainial direct current stimulation (tDCS) has become increasingly popular over the past decade. tDCS is a safe and well-studied form of non-invasive brain stimulation.
- Trial name
- NCT03453983
- Testing
- Transcrainial Direct Current Stimulation (tDCS)
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of Calgary
Alcohol Use Disorder (AUD), Alcoholism
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans.
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Smoking, Tobacco
- Trial name
- ReCoDe (NCT05992272)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Trier Social Stress Test
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Parkinson's Disease, Movement Disorders
Imaging Blood Brain Imaging Dysfunction in Parkinson's Disease
The purpose of this study is to evaluate the blood brain barrier in the striatum of patients that have other types of movement disorders compared to patients with Parkinson's Disease that are receiving similar treatment, to…
- Trial name
- NCT02605161
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Ottawa Hospital Research Institute
Autism Disorder, Language Development Disorders
Rural Autistic Individuals - Supporting Expression
This research study investigates how hand gestures can support language comprehension and communication skills of hearing speaking, non-speaking, and/or minimally verbal individuals with Autism Spectrum Disorders (ASD), who are…
- Conditions
- Autism Disorder, Language Development Disorders, ADHD, Typical Development
- Trial name
- RAISE (NCT07054866)
- Testing
- Speech-Gesture combinations
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Montana State University
Anorexia Nervosa
Serotonin Role on Brain Circuits Involved in Food Avoidance in Anorexia Nervosa
Serotoninergic activity in brain structures involved in food control and avoidance, such as the basal ganglia, is poorly understood in Anorexia Nervosa.
- Trial name
- SEVIALANO (NCT05155280)
- Testing
- PET imaging using [11C]DASB radioligand., Eye Tracker
- Where
- France
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cerebral Palsy, Spastic, Hemiplegic Cerebral Palsy
Upper Limb Somatosensory Discrimination Therapy and Dose-matched Motor Therapy in Children and Adolescents With Unilateral Cerebral Palsy
A randomized, controlled, and evaluator-blinded trial will be carried out to investigate the effects of 8 weeks of upper limb somatosensory discrimination therapy compared to an equal dose of motor therapy on sensorimotor…
- Trial name
- NCT06006065
- Testing
- Upper limb somatosensory discrimination therapy, Upper limb motor therapy
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Hilde Feys
Disorder of Consciousness, Minimally Conscious State
Simultaneously PET/MRI in Prolonged DOC Patients
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary…
- Conditions
- Disorder of Consciousness, Minimally Conscious State, FDG-PET, Rs-fMRI
- Trial name
- NCT04164680
- Testing
- Multimodal Neuroimaging
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hangzhou Normal University
Gender Identity, Gender Dysphoria in Adolescents and Adults
Puberty, Testosterone, and Brain Development
Transmasculine youth (female sex assigned at birth, male gender identity) who begin clinical gender affirming hormone therapy (GAHT) with testosterone (T) may experience changes in headache.
- Conditions
- Gender Identity, Gender Dysphoria in Adolescents and Adults, Headache, Transgender
- Trial name
- NCT06670053
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Cerebrovascular Accident, Focal Infarct
Database for Stroke in Infants and Children: the International Pediatric Stroke Study
The International Pediatric Stroke Study (IPSS) was established in 2003 as a multi-center, multi-national clinical research registry.
- Trial name
- IPSS (NCT00084292)
- Where
- Canada
- Volunteers
- 12,000 people
- Sponsor
- The Hospital for Sick Children
Irritable Mood
Dose Response Relationship of Oxytocin on Irritability in Youths
The proposed study is a randomized, double-blind proof of concept (PoC) study on the neural impact of intranasal oxytocin (OXT) administration for adolescents (age 14 to 18), demonstrating a clinically significant level of…
- Trial name
- NCT03863288
- Testing
- Functional MRI (fMRI), Oxytocin Intranasal Spray 8 International Unit (8IU), Oxytocin intranasal spray 24 International Unit (24IU)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Nebraska
Autism Spectrum Disorders
Emotional and Change-related Attention in Autism
Several studies seem to indicate that emotional attention and change-related attention are impaired in ASD. The goal of this study is to identify the relationships between those two types of automatic attention in visual and…
- Trial name
- AUTATTEN (NCT02160119)
- Testing
- MRI-based techniques, EEG
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France