Clinical trials: Neurological Condition
Moderate to Severe Acute Postoperative Pain
Use of Tapentadol Oral Solution for Pain After Surgery in Children From Newborn to Less Than 2 Years Old
This is a multicenter, open-label (all people involved know the identity of the intervention), single dose trial to evaluate the pharmacokinetic (PK) profile (how drugs are absorbed in the body, how are they distributed within…
- Trial name
- NCT02221674
- Testing
- Tapentadol
- Where
- 7 sites in United States, Poland and 1 more
- Volunteers
- 40 people
- Sponsor
- Grünenthal GmbH
Reactive Airways Dysfunction Syndrome (Disorder), Muscle Weakness
Efficacy of Inspiratory Muscle Training on Elite Swimmers
This study is a randomized controlled trial on the efficacy of inspiratory muscle training on swimming performance, airway dysfunction and perceived breathlessness in elite swimmers.
- Conditions
- Reactive Airways Dysfunction Syndrome (Disorder), Muscle Weakness, Dyspnea
- Trial name
- PEAK (NCT03062735)
- Testing
- Inspiratory Muscle Training
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Severe Acute Pain
A Non-randomised, Non-inferiority Comparative Study of Oral Actiskenan (Morphine Sulfate) Versus Intranasal Sufentanil in the Early Management of Severe Acute Pain in Emergency Departments.
The main objective of this study is to evaluate whether the analgesic protocol combining oral Actiskenan is non-inferior to the protocol combining intranasal Sufentanil for treating severe pain in patients admitted to the…
- Trial name
- SA-URGE (NCT07344350)
- Testing
- Intranasal Sufentanil, Oral Actiskenan
- Where
- 2 sites in France
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Pain, Pain, Acute
Opioid Use and Predicting Factors at the Emergency Department
Background: Increasing opioid misuse is a worldwide problem. About 10% of opioid misusers are primarily exposed to opioids at the Emergency Department (ED).
- Trial name
- VRxOPUS-1 (NCT06072950)
- Testing
- Usual care
- Where
- Netherlands
- Volunteers
- 149 people
- Sponsor
- Radboud University Medical Center
Language Disorder
Parent Child Interaction Therapy vs Conventional Parent Led Therapy in Down Syndrome
To determine the effect of Parent child interaction therapy vs Conventional Parent Led Therapy in the management of language disorders in Children with Down Syndrome
- Trial name
- NCT07128810
- Testing
- Parent Child Interaction Therapy, Conventional Parent Led Therapy
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Scoliosis, Pain
Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients
Acute pain management following major surgical procedures in pediatric patients continues to be a challenge, especially after extensive posterior spine fusions.
- Trial name
- NCT02558010
- Testing
- Methadone, Normal Saline, Morphine
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Medical College of Wisconsin
Chronic Pain
An Online Pain Education Program for Working Adults
Pain is popular among working population and it is a strong predictor of poor quality of life. In this study, an internet-delivered pain education program will be provided to working adults aims at helping patients equip with…
- Trial name
- NCT03952910
- Testing
- Online pain education program
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Blindness
Pars Plana Surgical Capsulotomy for Posterior Capsular Opacification
Cataract is a leading cause of Global blindness. After cataract surgery nearly half of the people become blind due to posterior capsular opacification. The only solution for this problem is LASER capsulotomy.
- Trial name
- Capsulotomy (NCT00964613)
- Volunteers
- 176 people
- Sponsor
- Dow University of Health Sciences
Pain, Fear
Venous Blood Sampling-Related Pain and Fear
This study is an experimental randomized controlled study conducted to compare the effect of balloon blowing, coughing, and ball squeezing methods applied during venous blood sampling from on pain and fear level in 7-12 year-old…
- Trial name
- NCT03720808
- Testing
- Balloon Blowing, Ball Squeezing, Coughing
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Learning Disorders, Depression
Move and Feel Good : Effects of Intensive Physical Training on Brain Plasticity, Cognition and Psychological Well-being.
The investigators perform a prospective, randomized, clinical study involving students in education with mood disorders and randomized to an intensive exercise program or a control relaxation activity.
- Conditions
- Learning Disorders, Depression, Anxiety
- Trial name
- Move&FG (NCT02970825)
- Testing
- Exercise, Relaxation
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Neurological Menfestions in Neonatal Sepsis
Detection of Neurological Manifestations Among Neonates With Sepsis
This observational prospective study aims to detect neurological menifestations in neonates with sepsis attending Assiut University Children Hospital
- Trial name
- NCT07813689
- Volunteers
- 100 people
- Sponsor
- Assiut University
Cerebral Palsy
Managing Post-operative Pain in Children With Cerebral Palsy Using a Pain Pump
The purpose of this study is to determine which pain management strategy continuous analgesic pump or orally-should be used in the management of children with cerebral palsy.
- Trial name
- NCT00884650
- Testing
- oral analgesic, intravenous analgesic per pump
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Prader-Willi Syndrome
Mitochondrial Complex I Dysfunction in PWS
Prader-Willi Syndrome (PWS) is characterized by profound infantile hypotonia, growth delay, cognitive impairment, muscle weakness and exercise intolerance.
- Trial name
- NCT03831425
- Testing
- Coenzyme Q10
- Where
- Canada
- Sponsor
- The Hospital for Sick Children
Sleep, Sleep Disturbance
Sleep Promotion Program Primary Care
Investigators developed a brief, scalable, behavioral Sleep Promotion Program (SPP) for adolescents with short sleep duration and sleep-wake irregularity, which relies on two individual sessions and smart phone technology to…
- Conditions
- Sleep, Sleep Disturbance, Insufficient Sleep
- Trial name
- SPP PC (NCT06240325)
- Testing
- SPP, Sleep Psychoeducation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Pain
Metabolism and Toxicity of Acetaminophen
The purpose of this study is to investigate how acetaminophen (APAP) is released into the urine and blood; to determine how the blood levels of acetaminophen and its breakdown products affect the preterm infant's health; to…
- Trial name
- NCT01328808
- Testing
- Acetaminophen/APAP
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- John van den Anker
Hearing Loss, Cochlear, Cochlear Implantation
Post-Market Clinical Investigation of the IotaSOFT Insertion System
The purpose of the proposed study is to evaluate the continued safety of the iotaSOFT Insertion System when used by a surgeon to assist with inserting a CI electrode array in one ear per subject
- Conditions
- Hearing Loss, Cochlear, Cochlear Implantation, Hearing Loss, Sensorineural
- Trial name
- ACE (NCT06664697)
- Testing
- Cochlear Implantation with Robotic-Assisted Insertion System
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- iotaMotion, Inc.
Silver Russell Syndrome, Beckwith-Wiedemann Syndrome
IDMet (RaDiCo Cohort) (RaDiCo-IDMet)
The goal of this observational study is to describe the natural history of imprinting disorders (IDs) according to their metabolic profile in all patients (adults and children) affected with an ID regardless of the severity of…
- Conditions
- Silver Russell Syndrome, Beckwith-Wiedemann Syndrome, Transient Neonatal Diabetes Mellitus, Angelman Syndrome
- Trial name
- IDMet (NCT05945576)
- Where
- 20 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intellectual Disability
Targeted Next Generation Sequencing and Intellectual Disability
The purpose is to determine the benefit of next generation sequencing (NGS) targeted on genes involved in intellectual disability for etiologic diagnosis of intellectual disabilities.
- Trial name
- NGS-DI (NCT02889068)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Nociceptive Pain, Anesthesia
Comparison of the Surgical Pleth Index and the Nociception Level Index in the Pediatric Population
This observational study aims to compare two nociception monitoring methods. The Nociception Level (NOL) index and the Surgical Pleth Index (SPI) in the pediatric population during general anesthesia.
- Conditions
- Nociceptive Pain, Anesthesia, Pediatric Anesthesia, Nociception Monitoring
- Trial name
- NOLvsSPI (NCT07084935)
- Testing
- Connecting all patients to the nociception level index(NOL) and the surgical pleth index (SPI), All patient will receive a tetanic stimuli (60mA, 100hz) of 5 seconds before start of incision
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Congenital Cytomegalovirus, Cytomegalovirus Infections
Protein Biomarkers and Host RNA Expression Profiles in Congenital Cytomegalovirus Infection
This study seeks to identify and test host protein biomarkers and RNA expression profiles in dried blood spot samples as novel diagnostic markers of congenital cytomegalovirus sequelae and to improve the understanding of the…
- Conditions
- Congenital Cytomegalovirus, Cytomegalovirus Infections, Neonatal Infection, Sensorineural Hearing Loss
- Trial name
- NCT07635368
- Where
- 2 sites in Denmark
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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