Clinical trials: Neuromuscular Function
Cerebral Palsy, Arthrogryposis
Effects of Power Mobility on Young Children With Severe Motor Impairments
The purpose this study is to determine the effects of power mobility on the development and function of young children of young children whose severe physical disabilities limit their exploratory behaviors and may unnecessarily…
- Conditions
- Cerebral Palsy, Arthrogryposis, Spinal Muscular Atrophy, Other Central Nervous System or Musculoskeletal Disorders
- Trial name
- NCT01028833
- Testing
- Power mobility
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Oklahoma
Diving, Aquatic
Effect of Diving and Aquatic Exercises on Muscle Spasticity and Motor Function in Children With Spastic Cerebral Palsy
This study aims to evaluate the effect of diving and aquatic exercises on muscle spasticity and motor function in children with spastic cerebral palsy.
- Conditions
- Diving, Aquatic, Muscle Spasticity, Motor Function
- Trial name
- NCT06902168
- Testing
- Intensive swimming program
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Benha University
Duchenne Muscular Dystrophy (DMD), Cardiomyopathy
Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials
Dystrophin associated heart dysfunction is a leading cause of death in patients with Duchenne and Becker Muscular dystrophy (DMD/BMD) and Duchenne and Becker muscular dystrophy carriers (MDC); however, the evolution of heart…
- Conditions
- Duchenne Muscular Dystrophy (DMD), Cardiomyopathy, Becker Muscular Dystrophy, Carrier of Duchenne Muscular Dystrophy
- Trial name
- NCT07674758
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt University Medical Center
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
Brain Involvement in Dystrophinopathies Part 1
The objective of this study is to collect data from a large cohort of individuals with DMD and BMD focusing on the neurobehavioural aspects of these conditions and their correlation to the location of the DMD gene mutation.
- Trial name
- NCT04583917
- Where
- 7 sites in Denmark, France and 4 more
- Volunteers
- 377 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Neuromuscular Training, Dynamic Balance
Comparative Effects of Advanced Neuromuscular and Dynamic Balance Training Among Hockey Players
This randomized clinical trial aims to compare the effects of advanced neuromuscular training and dynamic balance training on strength, balance, and functional performance among male hockey players.
- Conditions
- Neuromuscular Training, Dynamic Balance, Athletic Performance
- Trial name
- NCT07845968
- Testing
- ADVANCED NEUROMUSCULAR TRAINING, DYNAMIC BALANCE TRAINING
- Where
- Pakistan
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Spinal Cord Injuries, Pain, Neuropathic
Using NI-ES to Treat Spinal Cord Injury (SCI)
NI-ES therapy is a treatment that is being studied to potentially treat pain associated with SCI and may help movement below the injury site.
- Trial name
- NCT04097015
- Testing
- Alpha-Stim M
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- SCI Research Advancement
Early Onset Scoliosis, Congenital Spinal Deformities
The Treatment of Progressive Early Onset Spinal Deformities: A Multi-Center Outcome Study
The purpose of this study is to examine the treatment, both surgical and non-surgical, of patients with any form of early onset scoliosis.
- Conditions
- Early Onset Scoliosis, Congenital Spinal Deformities, Infantile Idiopathic Scoliosis, Neuromuscular Spinal Deformity
- Trial name
- GSSG (NCT02299362)
- Where
- 27 sites in United States, Canada and 5 more
- Volunteers
- 2,602 people
- Sponsor
- Growing Spine Study Group
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Muscular Atrophy, Spinal
A Study of the Safety of Nusinersen (Spinraza®) and Its Effects on Motor Function in Koreans Living With SMA Treated During Their Usual Medical Care
In this study, researchers will learn more about the effects of nusinersen, also known as Spinraza®, in Korean participants with spinal muscular atrophy, also known as SMA.
- Trial name
- STANDARD (NCT04317794)
- Testing
- Nusinersen Sodium Injection
- Where
- 16 sites in South Korea
- Volunteers
- 74 people
- Sponsor
- Biogen
Duchenne Muscular Dystrophy
Use of Dynamic Arm Supports to Promote Activities of Daily Living in Individuals With DMD
This study is a longitudinal, randomized control trial evaluating the use of two commercially available dynamic arm support devices (1) Armon Ayura-Kinova and 2) JAECO WREX) to promote participation in activities of daily living…
- Trial name
- NCT03531788
- Testing
- Armon Ayura (Kinova), JAECO Wrex
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Roxanna Marie Bendixen
Neurofibromatosis Type 1
Functional Imaging and Reading Deficit in Children With NF1
A monocenter pilot study on the acceptability and feasibility of a functional MRI protocol in children with NF1 with or without reading disabilities.
- Trial name
- NCT02422732
- Testing
- Neuropsychological assessments, morphological and functional MRI (fMRI), genetic analysis
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Toulouse
Cerebral Palsy, Spastic
Functional Electrical Stimulation During Walking in Cerebral Palsy
Children with spastic cerebral palsy (CP) often walk with insufficient ankle dorsiflexion in the swing phase. A pathological gait, known as drop-foot gait, can be the result and this has 2 major complications: foot-slap during…
- Conditions
- Cerebral Palsy, Spastic, Foot Drop
- Trial name
- NCT03440632
- Testing
- FES
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Sarcopenia, Respiratory Function Impaired
Respiratory Sarcopenia in Institutionalized Older Adults in the Region of Murcia
Objectives: The objectives of this study are to describe the prevalence of respiratory sarcopenia in institutionalized older adults.
- Trial name
- NCT06130800
- Where
- Spain
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Felipe León Morillas
Neonatal Brachial Plexus Palsy
Forced Lefthandedness in Neonatal Brachial Plexus Palsy (NBPP) Children
The aim of the project is to assess the neurophysiological and functional consequences of forced lefthandedness in a population with right neonatal brachial plexus palsy (NBPP).
- Trial name
- NBPP (NCT04376372)
- Testing
- Functional testing, Magnetic resonance imaging, Electromyography
- Where
- Belgium
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Dysmenorrhea
Effect of Integrated Neuromuscular Inhibition Technique in Females With Menstrual Low Back Pain
Dysmenorrhea is a common problem in women of reproductive age. Primary dysmenorrhea is defined as recurrent, cramping pain occurring with menses in the absence of identifiable pelvic pathology .
- Trial name
- NCT05461846
- Testing
- integrated neuromuscular inhibition technique
- Volunteers
- 30 people
- Sponsor
- Cairo University
Androgen Insensitivity Syndrome, Metabolic Parameters in AIS, CAIS, PAIS and MAIS
Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals With Androgen Insensitivity
Background: Androgen effects in humans are usually (but not always) mediated by the androgen receptor which is coded for by the androgen receptor gene (AR gene).
- Conditions
- Androgen Insensitivity Syndrome, Metabolic Parameters in AIS, CAIS, PAIS and MAIS, Tumor Formation in AIS, CAIS, PAIS and MAIS, Sexual Function AIS, CAIS, PAIS and MAIS
- Trial name
- NCT04708431
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Hemiplegia and/or Hemiparesis Following Stroke
Exercise to Improve Sleep and Quality of Life in Stroke Patients Receiving Botulinum Toxin Treatment
This study aimed to investigate the contribution of aerobic exercise programmes to improving sleep quality, quality of life, and functional status, alongside conventional rehabilitation, in stroke patients who had received…
- Trial name
- NCT07369453
- Testing
- Aerobic exercise training using a cycle ergometer
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Focus on Healthy Infants
Development of Muscle Function in Prepubertal Children As a Response to Growth and Resistance Training
Healthy skeletal muscle development is crucial for a life-long quality of life. Childhood and puberty may be key periods for developing muscle growth and neuromuscular capacities, which are essential for bone-muscle interaction…
- Trial name
- decade-fit (NCT06594900)
- Testing
- resistance training intervention
- Where
- Switzerland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ralf Roth
Mitochondrial Myopathies
Niacin Supplementation in Healthy Controls and Mitochondrial Myopathy Patients
The most frequent form of adult-onset mitochondrial disorders is mitochondrial myopathy, often manifesting with progressive external ophthalmoplegia (PEO), progressive muscle weakness and exercise intolerance.
- Trial name
- NiaMIT (NCT03973203)
- Testing
- Niacin
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Muscle Spasticity, Cerebral Palsy
Radial Extracorporeal Shock Wave Therapy for Spastic Plantar Flexor Muscles in Young Children With Cerebral Palsy
The purpose of this study is to determine whether radial extracorporeal shock wave therapy in combination with traditional physical therapy is safe and effective for the management of spastic plantar flexor muscles in patients…
- Trial name
- NCT02719483
- Testing
- Swiss DolorClast, Traditional conservative therapy
- Volunteers
- 66 people
- Sponsor
- The First Hospital of Jilin University