Clinical trials: Neurotoxicity Syndrome
Respiratory Failure, Botulism
Treatment of Survivors After Botulism Outbreak
Background. Northern Thailand's biggest botulism outbreak to date occurred on 14 March 2006 and affected 209 people. Of these, 42 developed respiratory failure, and 25 of those who developed respiratory failure were referred to 9…
- Trial name
- NCT00314080
- Testing
- Botulinum AntiToxin, neuro-electrophysiologic study, repetitive nerve stimulation, Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure
- Where
- Thailand
- Volunteers
- 18 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Anesthesia and Neurotoxicity
Association Between Anesthetic Drugs for General Anesthesia and Postoperative Intelligence/behavioral Assessment Results in Children
In this study, we compared the results of the intelligence and behavioral test performed after surgery between the group using sevoflurane and the group receiving dexmedetomidine and remifentanil, in Korean children under 2 years…
- Trial name
- NCT04364945
- Testing
- dexmedetomidine, remifentanil, Sevoflurane
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Seoul National University Hospital
Trauma
The Effects of the Anesthetic Ketamine in Young Children Undergoing Procedural Sedation
In the emergency department (ED), ketamine is a popular anesthetic agent during sedation of children for painful and other short procedures.
- Trial name
- NCT02650154
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- The Hospital for Sick Children
Childhood B Acute Lymphoblastic Leukemia, Childhood T Acute Lymphoblastic Leukemia
Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia
This clinical trial is looking at brain function in young patients receiving methotrexate for acute lymphoblastic leukemia. Learning about the long-term effects of methotrexate on brain function may help doctors plan cancer…
- Conditions
- Childhood B Acute Lymphoblastic Leukemia, Childhood T Acute Lymphoblastic Leukemia, Cognitive Side Effects of Cancer Therapy, Long-Term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT00437060
- Testing
- Cognitive Assessment, Diffusion Tensor Imaging, Laboratory Biomarker Analysis
- Where
- 112 sites in United States, Australia and 2 more
- Volunteers
- 233 people
- Sponsor
- Children's Oncology Group
Anesthesia, Neurotoxicity
A Study to Compare the Long-term Outcomes After Two Different Anaesthetics
There is considerable evidence that most general anaesthetics modulate brain development in animal studies. The impact is greater with longer durations of exposure and in younger animals.
- Conditions
- Anesthesia, Neurotoxicity, Child Development
- Trial name
- TREX (NCT03089905)
- Testing
- Sevoflurane, Remifentanil, Dexmedetomidine
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 450 people
- Sponsor
- Murdoch Childrens Research Institute
Diffuse Intrinsic Pontine Glioma, PNET
Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors
This study will analyze the effects of radiation given to children who have tumors of the central nervous system (CNS). Researchers want to learn more about changes in the quality of life that patients may experience as a result…
- Conditions
- Diffuse Intrinsic Pontine Glioma, PNET, Ependymoma, Germinoma
- Trial name
- NCT01445288
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- National Cancer Institute (NCI)
Botulism
BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric Patients
The purpose of this study is to verify the pediatric dosing recommendations for BAT product in pediatric patients that are treated with BAT product due to a confirmed or suspected case of botulism.
- Trial name
- NCT02051062
- Testing
- Blood sample collection
- Volunteers
- 10 people
- Sponsor
- Emergent BioSolutions
Alcohol Withdrawal Delirium, Alcohol Withdrawal
Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome
Severe acute alcohol withdrawal syndrome is a potentially life-threatening condition characterized by agitation, confusion, abnormal heart rhythms and seizures.
- Conditions
- Alcohol Withdrawal Delirium, Alcohol Withdrawal, Alcohol Withdrawal Seizures
- Trial name
- PHENOMANAL (NCT03586089)
- Testing
- Phenobarbital Sodium
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Unity Health Toronto
Acute Leukemia
Evaluation of Brain Changes in ALL Patients on Therapy
The study is aimed at assessing changes in the brain of patients from 6 to 18 years old with a diagnosis of acute lymphoblastic leukemia during chemotherapy.
- Trial name
- NCT04767152
- Testing
- MRI
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Toxic Encephalopathy, Diquat Poisoning
Risk Stratification and Heterogeneity for Organ Damage in Acute Diquat Poisoning
This ambispective cohort study aims to characterize the relationship between plasma diquat concentrations and organ damage risk.
- Trial name
- NCT06798142
- Testing
- extracorporeal treatment
- Where
- China
- Volunteers
- 193 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma
Pharmacokinetics of Ch14.18 in Younger Patients With High-Risk Neuroblastoma
This research trial is studying how Ch14.18 acts in the body of younger patients with high-risk neuroblastoma. Studying samples of blood from patients with cancer receiving Ch14.18 may help doctors learn more about how this drug…
- Conditions
- Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Neurotoxicity Syndrome, Pain
- Trial name
- NCT01418495
- Testing
- Cytology Specimen Collection Procedure, Pharmacological Study
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Cytokine Release Syndrome
A Study of Itacitinib for the Prevention of Cytokine Release Syndrome Induced by Immune Effector Cell Therapy
"The purpose of this study is to assess the safety and efficacy of oral administration of itacitinib for the prevention of cytokine release syndrome (CRS) in male or female participants aged 12 years or older and who are planning…
- Trial name
- NCT04071366
- Testing
- Itacitinib, Immune effector cell therapy, Yescarta
- Where
- 10 sites in United States
- Volunteers
- 112 people
- Sponsor
- Incyte Corporation
Acute Lymphoblastic Leukemia, Immune System Diseases
Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL
The body has different ways of fighting infection and disease. No single way is effective at fighting cancer. This research study combines two different ways of fighting disease: antibodies and T cells.
- Conditions
- Acute Lymphoblastic Leukemia, Immune System Diseases, Immunoproliferative Disorders
- Trial name
- NCT03016377
- Testing
- iC9-CAR19 cells, Rimiducid, Cyclophosphamide
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
General Anaesthesia During Pregnancy
Intelligence and Neurodevelopmental Disorders After Prenatal Exposure to General Anaesthesia
Every year in the European Union, thousands of babies are exposed to anaesthesia before they are born because their mothers need surgery during pregnancy.
- Trial name
- PAE-IQ (NCT06633406)
- Testing
- Age-appropriate Wechsler Intelligence Test, Disruptive Behavior Disorders Rating Scale, Social Responsiveness Scale
- Where
- 3 sites in Belgium
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Kidney Cancer, Leukemia
Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer
RATIONALE: Glutamic acid may help lessen or prevent nerve damage caused by vincristine. It is not yet known whether glutamic acid is more effective than a placebo in preventing nerve damage in patients receiving vincristine for…
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Neurotoxicity
- Trial name
- NCT00369564
- Testing
- glutamic acid
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of South Florida
Neurotoxicity Syndromes
Scopolamine Treatment for Patients With Organophosphate Poisoning
Organophosphate (OP) compounds are a major threat as chemical warfare agents or in terrorist act. OPs are also the active ingredient of many insecticides.
- Trial name
- NCT00389259
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf-Harofeh Medical Center
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain
RATIONALE: Donepezil may decrease the side effects caused by radiation therapy to the brain. PURPOSE: This clinical trial is studying how well donepezil works in treating young patients with primary brain tumors previously…
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Long-term Effects Secondary to Cancer Therapy in Children, Neurotoxicity
- Trial name
- NCT00452868
- Testing
- Donepezil
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Non-small Cell Lung Cancer
Monosialoganglioside(GM1) Preventing Neurotoxicity Induced by Cisplatin Contained Chemotherapy in NSCLC Patients
Evaluate the efficacy and safety of Monosialoganglioside(GM1) to prevent the neurotoxicity induced by cisplatin
- Trial name
- NCT01882621
- Testing
- Monosialoganglioside(GM1), normal saline
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Acute Lymphoblastic Leukemia
Liposomal Cytarabine for Central Nervous System (CNS)-Treatment in High-risk Acute Lymphoblastic Leukemia (ALL)
Replacement of intrathecal Triple (methotrexate, cytarabine, prednisolone) with intrathecal liposomal cytarabine and prednisolone during maintenance therapy will decrease the CNS relapse rate in high-risk ALL patients.
- Trial name
- NCT00991744
- Testing
- Liposomal cytarabine, Intrathecal triple
- Where
- 5 sites in Denmark, Finland and 3 more
- Volunteers
- 100 people
- Sponsor
- Nordic Society for Pediatric Hematology and Oncology
Seizures, Development Delay
Review of Diagnostic Yield of MRI Brain Results in Children Under Age 3 Years
The investigators aim to identify the frequency with which an elective brain MRI yields and etiologic diagnosis to explain its indication.
- Conditions
- Seizures, Development Delay, Anesthetic Neurotoxicity
- Trial name
- NCT03561168
- Testing
- Change in plan of care based on MRI results
- Where
- United States
- Volunteers
- 561 people
- Sponsor
- Baylor College of Medicine