Clinical trials: Neutrophil Activation
Lung Disease
Sensing Using Neutrophil Activation Probe on the Intensive Therapy Unit
Critically ill patients often succumb to acute respiratory disease (rapidly developing disease affecting the lungs). The lungs are the commonest organ to fail and require support in the intensive care environment.
- Trial name
- SNAP-IT (NCT02804854)
- Testing
- Neutrophil Activation Probe (NAP)
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Edinburgh
Covid19
Involvement of Polymorphonuclear Neutrophils and Platelets in Severe Form of COVID-19
The main objective is to quantify the population of reverse migrating neutrophils in patients with COVID-19.
- Trial name
- NeutroVID (NCT04930757)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Wegener's Granulomatosis
Daclizumab to Treat Wegener's Granulomatosis
This study will examine the safety and effectiveness of daclizumab (also called Zenapax or anti-CD25) in patients with Wegener's granulomatosis, a type of vasculitis (blood vessel inflammation).
- Trial name
- NCT00040248
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intra Abdominal Infections, Appendicitis Acute
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study
The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.
- Conditions
- Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis
- Trial name
- NATURAL (NCT07579312)
- Testing
- TruNAV, an RNA-based blood test for host immune activation by infections
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- True Bearing Diagnostics, Inc.
Prematurity, Histologic Chorioamnionitis
Infant Immune Response to Bacterial Infection
This study will examine the response of white blood cells to bacterial infection in blood taken from the umbilical cords of newly delivered infants.
- Trial name
- NCT00546195
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Lung Cancer
Visualising c-MET and Activated Neutrophils in Lung Cancer
Lung cancer is currently a major health problem in the UK. Despite being one of the most common cancers, lung cancer has a poor prognosis compared to other types of cancer and is the leading cause of cancer death in the world.
- Trial name
- DUAL (NCT02676050)
- Testing
- Optical Imaging Agents (EMI-137, NAP), Delivery Device Cathetar and Miniaturised imaging fibre, Optical endomicroscopy system
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Edinburgh