Clinical trials: Next-generation Sequencing
Microbiome, Metagenomic Next Generation Sequencing
Norovirus Prevalence and Fecal Microbiome Characterization Through Metagenomic and Metatranscriptomic Analyses
The goal of this clinical trial is to characterize the fecal microbiome composition (including bacteria, archaea, viruses, fungi, and parasites) in fecal samples collected from travelers (including occupational travelers, leisure…
- Conditions
- Microbiome, Metagenomic Next Generation Sequencing, Norovirus Infection
- Trial name
- METATRAV (NCT07866469)
- Testing
- Characterization the fecal microbiome composition in travelers
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Pneumonia, Next-generation Sequencing
Monitoring of Antimicrobial Resistance Based on Metagenomics Analyses in Pneumonia Patients
Monitoring of antimicrobial resistance (AMR) based on metagenomics analyses in pneumonia patients is critical for optimizing clinical diagnosis and treatment and improving clinical prognosis.
- Conditions
- Pneumonia, Next-generation Sequencing, Microbiome, Antimicrobial Resistance
- Trial name
- NCT06566898
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shanghai General Hospital, China
Orofacial Clefts, Next Generation Sequencing (NGS)
Study of Congenital Orofacial Clefts by Implementing Optical Genome Mapping
Orofacial clefts, the most common congenital craniofacial malformations, have a complex etiology involving an interaction between genetic and environmental factors.
- Conditions
- Orofacial Clefts, Next Generation Sequencing (NGS), Optical Genome Mapping
- Trial name
- CARTOFENTE (NCT06880094)
- Testing
- blood withdrawal
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
B Cell Precursor Acute Lymphoblastic Leukemia, Pediatric
NGS MRD-Guided Blinatumomab Treatment for Pediatric B-ALL
The goal of this clinical trial is to determine whether pediatric B-cell acute lymphoblastic leukemia (B-ALL) patients with negative deep minimal residue disease (MRD) can benefit from blinatumomab treatment.
- Conditions
- B Cell Precursor Acute Lymphoblastic Leukemia, Pediatric, Minimal Residual Disease, Next Generation Sequencing (NGS)
- Trial name
- NCT06763302
- Testing
- Blinatumomab
- Volunteers
- 1,220 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Next Generation Sequencing, Pediatric Bacterial Meningitis
Application of Next Generation Sequencing Technique in Pediatric Bacterial Meningitis
Pathogen identification is of paramount importance for bacterial meningitis. At present, the pathogen of bacterial meningitis is still mainly based on Gram stain and bacterial culture.
- Trial name
- NCT03953638
- Testing
- Next Generation Sequencing
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Children's Hospital