Clinical trials: No Condition
Perforated Appendicitis
Irrigation Versus No Irrigation for Perforated Appendicitis
The purpose is to quantify the effect of irrigation during laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT00854815
- Testing
- Irrigation, No Irrigation
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Children's Mercy Hospital Kansas City
Bowel Cleansing Prior to Clinical Procedures, Colorectal Anastomosis
Oral Antibiotics vs. No Antibiotics in Pediatric Colorectal Surgery
This study aims to evaluate whether giving oral antibiotics before elective colorectal surgery can improve recovery and reduce complications in children.
- Trial name
- PEACO (NCT07713433)
- Testing
- oral antibiotics, No Oral Antibiotics
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Muhammad Zubair Shoukat
FAP-Familial Adenomatous Polyposis
Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version
Colorectal cancer (CRC) is a leading cause for cancer related mortality in the western world with a lifetime risk of 6%. Etiology is complex, while genetic background significantly affects the risk.
- Trial name
- NCT02354560
- Testing
- Erythromycin
- Volunteers
- 15 people
- Sponsor
- michal roll
Spasms, Infantile, Prednisolone
Clinical Trial on 7-day Followed by Maintenance Therapy for 10 Weeks vs. 14-day and no Maintenance Course of Prednisolone for the Treatment of Infantile Epileptic Spasms Syndrome (IESS)
The goal of this clinical trial is to learn if short courses (7 days) of oral prednisolone are as effective as longer courses (14 days) in treating Infantile Epileptic Spasms Syndrome (IESS) in infants.
- Trial name
- SLISS (NCT06838559)
- Testing
- Short-Duration Oral Prednisolone with Extended Tapering, Standard Oral Prednisolone Regimen with Tapering
- Where
- 7 sites in Sri Lanka
- Volunteers
- 182 people
- Sponsor
- University of Colombo
Melanoma
Program for Pembrolizumab (MK-3475) in Participants With Metastatic Melanoma Who Have Failed Standard of Care Therapy Including Ipilimumab (MK-3475-030)
This is an expanded access program (EAP) for participants who have progressed after prior systemic therapy including ipilimumab, and V-raf murine sarcoma viral oncogene homolog B1 (BRAF) inhibitor or mitogen-activated protein…
- Trial name
- NCT02083484
- Testing
- Pembrolizumab
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes
Retinal Ganglion Cell Complex Changes by Optical Coherence Tomography in Diabetic Patients Without Retinopathy
Neuroretinal damage in diabetes produces functional abnormalities such as the loss of chromatic discrimination,contrast sensitivity and dark adaptation.
- Trial name
- RGCC (NCT02620644)
- Testing
- OCT Retinal GCC
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Cairo University
Arrhythmia
The Effect of Proton Pump Inhibition on Palpitations
Feeling of palpitations with no clear arrhythmia is frequently encountered in clinical practice. The majority of these patients have documented sinus rhythm even while having symptoms.
- Trial name
- NCT03273634
- Testing
- Lansoprazole Pill
- Where
- Jordan
- Volunteers
- 150 people
- Sponsor
- Jordan Collaborating Cardiology Group
Asthma; Eosinophilic, Asthma Chronic
Characteristics of Type 2- High Inflammatory Endotype of Asthma Using New Biomarkers From Peripheral Blood and Exhaled Air and Its Effect on the Outcome of Therapy
The goal of this study is to identify reliable, valid, easily measurable, interpretable, and useful biomarkers in peripheral blood and exhaled air by people with severe asthma for a more accurate description of the pathogenetic…
- Conditions
- Asthma; Eosinophilic, Asthma Chronic, Bronchial Asthma, Asthma, Bronchial
- Trial name
- NCT05270278
- Where
- Czechia
- Volunteers
- 89 people
- Sponsor
- Value Outcomes Ltd.
Argininosuccinate Lyase Deficiency, Urea Cycle Disorder
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD
This is a study involving a dietary supplement. Patients with argininosuccinate lyase deficiency (ASLD) will be randomly assigned to receive either a nitric oxide dietary supplement or placebo for 24 weeks, and then crossed-over…
- Conditions
- Argininosuccinate Lyase Deficiency, Urea Cycle Disorder, Urea Cycle Disorders, Inborn, Argininosuccinic Aciduria
- Trial name
- NCT03064048
- Testing
- Neo-ASA
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Baylor College of Medicine
Hematologic Malignancy, Myeloid Malignancy
Pediatric Study of GVHD Ppx w/o Calcineurin Inhibitors After Day60 Post First Allo HSCT for Hematological Malignancies.
The participants are being asked to take part in this clinical trial because the participant have a lymphoid or myeloid based cancer diagnosis that requires a bone marrow transplant.
- Trial name
- NCT05579769
- Testing
- Ruxolitinib, Mesna, Anti-thymocyte globulin (ATG)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- St. Jude Children's Research Hospital
Myelodysplastic Syndrome, Chemotherapy
Effect of Chemotherapy vs No Chemotherapy Pre-transplant to MDS Undergoing Allo-HSCT
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) appears to be an efficient tool to cure refractory anemia with excess blasts-1 (RAEB-1), refractory anemia with excess blasts-2 (RAEB-2) and acute myeloid leukemia…
- Trial name
- NCT02850822
- Testing
- Demethylation drug, Chemotherapy regimen
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Lice
Effectiveness of "No More" Anti-lice Medical Device to Kill Lice and Lice Eggs
The purpose of this study is to determine effectiveness of an Anti-lice treatment using the medical device "No More" which is designed to kill lice and lice eggs on the head.
- Trial name
- NCT02569580
- Testing
- Topically
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pharmayeda
Immunity, Diarrhea
A Study on Immunological Effect of Vitamin A and Zinc in a Placebo Controlled 4 Cell Trial
Vitamin A deficiency in children is associated with increased mortality and morbidity due to respiratory tract and diarrhoeal infections.
- Conditions
- Immunity, Diarrhea, Respiratory Tract Infections
- Trial name
- NCT00374023
- Testing
- Zinc, or Vitamin A or both
- Where
- Bangladesh
- Volunteers
- 147 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Atrial Fibrillation
AIHEMAF - P "An Innovative Healthcare Model for AF Patients"
Non-profit observational study on the role of the community pharmacist and "the pharmacy of services" in the case management of patients suffering from atrial fibrillation and being treated with new generation oral anticoagulants
- Trial name
- AIHEMAF - P (NCT05086991)
- Testing
- Follow up
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Farmacia La Regina s.r.l.
Non-small Cell Lung Cancer
Clinical Study Testing DNA Extracted From Tumour Tissue Biopsy Samples, Using the Therascreen® KRAS RGQ PCR Kit
An interventional, prospective study. It is estimated that up to 800 patient tissue samples (from approximately 650 patients enrolled at approximately 300 clinical trial sites), will be obtained as part of enrolment into Phase 3…
- Trial name
- NCT05347797
- Testing
- therascreen® KRAS RGQ PCR Kit
- Where
- United Kingdom
- Volunteers
- 495 people
- Sponsor
- QIAGEN Gaithersburg, Inc
HbS Disease, Hemoglobin S Disease
A Trial to Assess Haploidentical T-depleted Stem Cell Transplantation in Patients With SCD
HSCT is currently the only curative option for SCD but less than 20% of SCD patients have a MD donor available. So far, all curative approaches beyond a MSD HSCT at young age are non-satisfactory.
- Conditions
- HbS Disease, Hemoglobin S Disease, Sickle Cell Anemia, Sickle Cell Disorders
- Trial name
- NCT04201210
- Testing
- TCRα/β+ and CD19+ depleted haploidentical stem cell transplantation, Matched sibling donor transplantation
- Where
- 9 sites in Austria, Germany
- Volunteers
- 212 people
- Sponsor
- University of Regensburg
Hernia, Inguinal, Inguinal Hernia, Direct
Study of Laparoscopic Inguinal Hernia Repair
Although mesh fixation has been associated to an increased incidence of nerve injury and involves increased operative costs, many surgeons feel that fixation is necessary to reduce the risk of hernia recurrence.
- Conditions
- Hernia, Inguinal, Inguinal Hernia, Direct, Inguinal Hernia, Indirect, Hernia, Femoral
- Trial name
- NCT02920307
- Testing
- TEP without fixation, TEP with fixation, TAPP without fixation
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Medical Park Gaziantep Hospital
Angina Pectoris, Microvascular Angina
Angina in Non Coronary Artery Disease
Many patients undergoing coronary angiography are found to have no significant coronary artery disease (CAD) despite angina equivalent symptoms and/or electrocardiographic abnormalities suggestive of myocardial ischemia.
- Conditions
- Angina Pectoris, Microvascular Angina, Angina Pectoris, Variant
- Trial name
- HeartQuest (NCT01318629)
- Where
- Switzerland
- Volunteers
- 718 people
- Sponsor
- Luzerner Kantonsspital
no Spedific Condition, All-cause In-patient Mortality
Nurse Graduateness and Patient Outcomes: a Cross Sectional Pilot Study
This research project is relevant to the identification of the relationship, and its significance, between patient morality and a number of demographic, clinical and corporate characteristics.
- Trial name
- NCT02705001
- Testing
- all admissions except accident and emergency
- Volunteers
- 1,252 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Verruca (Warts)
A Comparative Study of Occlusive Heat Patch in the Treatment of Warts
The goal of this study is to determine the safety and efficacy of the occlusive heat patch for the treatment of verrucae (warts).
- Trial name
- NCT01746056
- Testing
- Occlusive Heat Patch
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Yale University