Clinical trials: Non Cystic Fibrosis Bronchiectasis
Non-Cystic Fibrosis Bronchiectasis
A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis
The primary objective of this study is to evaluate the effect of brensocatib at 10 mg and 25 mg compared with placebo on the rate of pulmonary exacerbations (PEs) over the 52-week treatment period.
- Trial name
- ASPEN (NCT04594369)
- Testing
- Brensocatib 10 mg, Brensocatib 25 mg
- Where
- 373 sites in United States, Argentina and 34 more
- Volunteers
- 1,767 people
- Sponsor
- Insmed Incorporated
Emphysema, Chronic Obstructive Pulmonary Disease (COPD)
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability
The purpose of this research study is to learn about the safety of transplanting lungs obtained from non-heart-beating donors (NHBDs) that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and…
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease (COPD), Cystic Fibrosis, Pulmonary Fibrosis
- Trial name
- NCT01615484
- Testing
- Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™, STEEN Solution™
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Non-cystic Fibrosis Bronchiectasis
Procalcitonin as a Marker of Severity of Non-cystic Fibrosis Bronchiectasis in Children
The aim of this study is to evaluate the role of procalcitonin in bronchoalveolar lavage as a biomarker for assessment of severity of non-CF bronchiectasis in children in correlation with other markers (functional and…
- Trial name
- NCT06352944
- Testing
- procalcitonin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Non-Cystic Fibrosis Bronchiectasis
An Expanded Access Study to Assess Brensocatib for Participants With Non-Cystic Fibrosis Bronchiectasis
The purpose of this study is to allow early access to brensocatib for participants with non-cystic fibrosis bronchiectasis (NCFBE) who have successfully completed the INS1007301 ASPEN Clinical trial.
- Trial name
- NCT05344508
- Testing
- Brensocatib
- Sponsor
- Insmed Incorporated
Cystic Fibrosis and Non CF Bronchiectasis
The Role of Vitamin D3 in Pediatric Bronchiectasis Severity
Vitamin D3 therapy was effective in decreasing the frequency of pulmonary exacerbations and preserving lung functions , thereby improving the disease severity even more in non CF than CF bronchiectasis patients
- Trial name
- NCT04411901
- Testing
- Cholecalciferol (vitaminD3)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Heba Omara
Non Cystic Fibrosis Bronchiectasis in Children
The Efficacy of Azithromycin in Treating Children With Non Cystic Fibrosis Bronchiectasis
Bronchiectasis is characterized by a permanent and abnormal dilatation of a part of the bronchial tree. An accumulation of mucus in the respiratory tract ensues, resulting in frequent bacterial infections and eventual destruction…
- Trial name
- AZI-STOP (NCT02531984)
- Testing
- Azithromycin
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Bronchiectasis, Cystic Fibrosis
A Study of the Clinical Benefit of Tobramycin Inhalation Solution
This project will use literature analysis, expert research, real-world data mining and other methods to investigate the current status of the application of antimicrobial aerosolized inhalation in healthcare institutions, combine…
- Conditions
- Bronchiectasis, Cystic Fibrosis, Lung Infection
- Trial name
- NCT06106789
- Testing
- Tobramycin inhalation solution
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Qianfoshan Hospital
Cystic Fibrosis, Bronchiectasis
Comparison of the Efficacy of Comprehensive Respiratory Physiotherapy in Children With Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis
The effect of comprehensive respiratory physiotherapy applications on respiratory function, functional capacity and peripheral muscle strength in children with cystic fibrosis and non-cystic fibrosis will be compared.
- Trial name
- NCT04170114
- Testing
- Comprehensive Respiratory Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bezmialem Vakif University
Cystic Fibrosis, Bronchiectasis
Safety, Tolerability and Efficacy of S-1226 in Cystic Fibrosis and Non CF Bronchiectasis
This is a single center, open label, Phase IIa, multiple-ascending dose study in which subjects with mild to moderate Cystic Fibrosis and non CF bronchiectasis (n≤12) will be enrolled.
- Trial name
- NCT03903913
- Testing
- S-1226
- Where
- 3 sites in Canada
- Volunteers
- 12 people
- Sponsor
- SolAeroMed Inc.
Cystic Fibrosis (CF), Non Cystic Fibrosis Bronchiectasis
Feasibility and Acceptance of SonoHeal for Airway Clearance and Preliminary Comparison With the Standard of Care
The proposed study is to gauge the early feasibility and acceptance of the SonoHeal device. The study will evaluate the usability of the SonoHeal prototype using well-established Human Factors Engineering methods recommended by…
- Conditions
- Cystic Fibrosis (CF), Non Cystic Fibrosis Bronchiectasis, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07568119
- Testing
- Airway clearance therapy through acoustic oscillations
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cognita Labs LLC
Cystic Fibrosis, Non-CF Bronchiectasis
Regional Phenotyping of CF and Non-CF Bronchiectasis
The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy…
- Trial name
- NCT04793867
- Testing
- Xenon
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bronchiectasis
Exercise Capacity in Patients With Cystic Fibrosis vs. Non-cystic Fibrosis Bronchiectasis
Introduction: Bronchiectasis is a chronic lung disease in which the underlying condition causes permanent damage to the conducting airways. Bronchiectasis is associated with considerable morbidity and poor quality of life.
- Trial name
- NCT03147651
- Where
- Israel
- Volunteers
- 119 people
- Sponsor
- Rambam Health Care Campus
Bronchiectasis
Effects of Azithromycin on Airway Oxidative Stress Markers in Patients With Bronchiectasis
The mechanism by which macrolide antibiotics have immune modifying effects independent from its antibacterial activity has not been well established.
- Trial name
- NCT01463371
- Testing
- Azithromycin
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Non-cystic Fibrosis Bronchiectasis
A Translational Study for Phenotyping and Endotyping Chinese Patients With NCFBE
Non-cystic fibrosis bronchiectasis (NCFBE) is a chronic respiratory disease characterized by a clinical syndrome of chronic productive cough and recurrent respiratory infections in the presence of abnormal and permanent dilation…
- Trial name
- NCT07245407
- Testing
- Participant Follow-up
- Where
- 38 sites in China
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Suppurative Lung Disease, Protracted Bacterial Bronchitis
Digital Physiotherapy for Pediatric Chronic Suppurative Lung Diseases
This is a prospective, single-center, two-arm (1:1), assessor-blinded, randomized controlled clinical trial that will be conducted in collaboration with the outpatient clinic of the third Pediatric Pulmonology Unit, "Attikon"…
- Conditions
- Chronic Suppurative Lung Disease, Protracted Bacterial Bronchitis, Primary Ciliary Dyskinesia (PCD), Non Cystic Fibrosis Bronchiectasis
- Trial name
- NCT07376187
- Testing
- Videoconferencing (Vsee platform), Specially designed website (FysΑΩ)
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- University of Thessaly
Non Cystic Fibrosis Bronchiectasis
HFCWO in Children With Non-CF Bronchiectasis
the study will concentrate on the effect of High Frequency Chest Wall Oscillation compared to conventional pulmonary physiotherapy on children with non cystic fibrosis bronchiectasis
- Trial name
- NCT07722364
- Testing
- High Frequency Chest Wall Oscillation, conventional physiotherapy program directed towards improvement of pulmonary functions and quality of life.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sphinx university
Bronchiectasis, Bronchiectasis Adult
Compare Oral Itraconazole and Standard Care Versus Standard Care Alone in Patients With Non-cystic Fibrosis Related Bronchiectasis With Chronic Aspergillus Infection in Reducing Bronchiectasis Exacerbations
There is an intricate link between bronchiectasis and fungi. Patients with cystic fibrosis frequently manifest fungal sensitization and fungal colonization with Aspergillus fumigatus.6 Aspergillus species also has a…
- Trial name
- BAIT (NCT06160713)
- Testing
- Itraconazole 65 MG, Standard care
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Non Cystic Fibrosis Bronchiectasis
Nutritional Status and Intake in Patients With Non-cystic Fibrosis Bronchiectasis (NCFB)
The aim of this study was to characterise nutritional status and dietary intake in a population of individuals living with bronchiectasis from a regional clinic.
- Trial name
- NCT06877091
- Where
- United Kingdom
- Volunteers
- 129 people
- Sponsor
- University of Leeds