Clinical trials: Non-Invasive Ventilation
Neuromuscular Diseases, Respiratory Failure
Establishment of a Non-invasive and Indirect Measure of Volitional Pimax
Respiratory failure is the main death cause in muscular diseases. Non-invasive and volitional measures of inspiratory muscles strength include the nasal pressure with an occluded nostril and the maximal inspiratory pressure…
- Trial name
- PI MAX STIM (NCT02242162)
- Testing
- phrenic nerves magnetic stimulations
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Respiratory Insufficiency
Sonographic Evaluation of Diaphragmatic Function Under Nasal High-flow (NHF) and Non-invasive Ventilation (NIV) in Respiratory Insufficiency
The aim of the study is to investigate the influence of respiratory support on diaphragmatic function (O2, NHF, NIV). The effects on the diaphragm, the respiratory values (FEV1, respiratory rate) and the subjective well-being of…
- Trial name
- SENNI (NCT07050147)
- Testing
- Nasal high flow, NIV
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Klinikum Emden
Respiratory Failure, Mechanical Ventilation Complication
Patient-ventilator Asynchrony During Mechanical Non-Invasive Assisted-ventilation in Pediatric Patients (NavPed-NI)
The purpose of this study is to document the prevalence and type of asynchronies incidence during non-invasive mechanical ventilation in pediatric patients breathing under pressure support.
- Trial name
- NavPed-NI (NCT01238757)
- Testing
- Non-invasive Ventilation under Pressure Support, Non-Invasive ventilation under NAVA
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University Hospital, Geneva
Sleep-Disordered Breathing
Home Initiation of Noninvasive Positive Pressure Ventilation in Children With Medical Complexity
Children with medical complexity (CMC) often have trouble breathing at night and need to use a breathing machine. This breathing machine is called noninvasive positive pressure ventilation (NiPPV).
- Trial name
- NCT05881031
- Testing
- Home Initiation of NiPPV
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
Apnoea, Prematurity
Automated Apnoea Detection in Preterms on Non-invasive Ventilation
The aim of this study is to monitor the frequency of apnoeas (pauses in breathing) on various methods of non-invasive respiratory support that are detected by an automated machine-learning (ML) model based on diaphragmatic…
- Trial name
- NCT07794007
- Testing
- Diaphragmatic electromyography
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Bronchiectasis
Airway Clearance in Bronchiectasis: is Non-Invasive Ventilation a Useful Adjunct in Moderate to Severe Disease?
This clinical trial is investigating the efficacy of Non Invasive Ventilation (NIV) as a method of airway clearance in patients with an acute exacerbation and moderate to severe bronchiectasis disease.
- Trial name
- NCT00522314
- Testing
- NIV and ACBT, Active Cycle of Breathing Techniques
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Ulster
Infant, Premature, Diseases, Infant, Newborn, Disease
Noninvasive High Frequency Oscillatory Ventilation as a Post-extubation Respiratory Support in Neonates
A randomized controlled trial comparing Noninvasive high frequency oscillatory ventilation (NHFOV) and Noninvasive positive pressure ventilation (NIPPV) as post-extubation respiratory support in preterm neonates with respiratory…
- Conditions
- Infant, Premature, Diseases, Infant, Newborn, Disease, Respiratory Tract Diseases, RDS
- Trial name
- NCT05493527
- Testing
- noninvasive high frequency oscillatory ventilation, noninvasive positive pressure ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Preterm Infants
NHFOV vs. NCPAP as a Primary Treatment to Neonatal Respiratory Distress Syndrome(NRDS)
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -noninvasive high-frequency oscillatory ventilation (nHFOV) or nasal continuous positive airway pressure (nCPAP) -as a…
- Trial name
- NCT03099694
- Testing
- noninvasive high-frequency ventilation (nHFOV), nasal continuous positive airway pressure (nCPAP)
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xingwang Zhu
Extubation Failure, Acute Respiratory Failure Post Extubation
Prevention of Reintubation by Using Noninvasive Positive Pressure Ventilation
Child extubation failure range from 4.1% to 19%. Studies in adults and children showed that extubation failure increases mortality mainly in those who need reintubation as this is a invasive procedure associated with many…
- Trial name
- NCT00977002
- Testing
- Positive Pressure Noninvasive ventilation, Inhalatory O2
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Sleep Apnea, Pediatric Sleep Apnea
Use of a 3D Printer to Make Custom Sleep Masks for Positive Airway Pressure Treatment
This is a small pilot study to look at the feasibility of creating a customized sleep mask for use with Continuous Positive Airway Pressure (CPAP) or other similar treatments for sleep apnea.
- Trial name
- NCT02896751
- Testing
- 3D printed NIV mask
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Lung Disease of Prematurity, Bronchopulmonary Dysplasia
Relationship Between EIT and Respiratory Status in Very Preterm Infants
Electrical Impedance Tomography (EIT) is a non-invasive imaging technique that can measure lung function in real time. This study will follow premature infants to see if EIT can help predict which infants will be successful in…
- Conditions
- Chronic Lung Disease of Prematurity, Bronchopulmonary Dysplasia, Premature Lungs
- Trial name
- NCT06609135
- Testing
- Sentec LuMon Device (EIT system), Sentec Digital Monitoring System (transcutaneous CO2 monitor)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Lawrence Rhein
Infant, Premature, Diseases, Birth, Preterm
The NEU - CAP Trial
The aim of NEU-CAP is to investigate the clinical impact of using a colorimetric carbon dioxide (CO₂) detector during non-invasive ventilation (NIV). Infants born before 32 weeks of gestation will be included in this trial.
- Conditions
- Infant, Premature, Diseases, Birth, Preterm, Respiratory Distress Neonatal
- Trial name
- NEU-CAP (NCT07754032)
- Testing
- Local standard care of monitoring non-invasive ventilation, CO₂-guided Non-Invasive Ventilation
- Volunteers
- 1,860 people
- Sponsor
- Leiden University Medical Center
Noninvasive Positive Pressure Ventilation;, Sedation;
Interventional Bronchoscopy Under Noninvasive Ventilation
To evaluate the effect and safety of noninvasive ventilation assisted interventional bronchoscopy for hypoxemia patients with central airway stenosis.
- Conditions
- Noninvasive Positive Pressure Ventilation;, Sedation;, Bronchoscopy；, Interventional；
- Trial name
- NCT02289586
- Testing
- invasive ventilation, interventional bronchoscopy, noninvasive ventilation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Futian People's Hospital
Respiratory Distress Syndrome, Premature Infants
Effects of Non-invasive Ventilation With Helium-oxygen Mixture in Premature Infants With Respiratory Distress Syndrome
The use of a mixture of helium with oxygen (heliox) as a breathing gas may be beneficial due to its unique physical properties, such as low density and high carbon dioxide (CO2) diffusion coefficient.
- Trial name
- NCT04404816
- Testing
- heliox
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Poznan University of Medical Sciences
Preterm Infant
Effect of Kinesiotaping Application in Preterm Infants Undergoing Noninvasive Ventilation
Kinesiotaping (KT) applied to the thorax is believed to enhance breathing by supporting the respiratory muscles. Infants born premature usually have respiratory problems because of depletion of surfactant and respiratory muscle…
- Trial name
- NCT03660358
- Testing
- kinesiotape application
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Baskent University
Pediatric Sleep Apnea, Obstructive Sleep Apnea
Photobiomodulation for Pediatric Hypertrophic Tonsils
Pediatric obstructive sleep apnea is a medical condition where a child has great difficulty with breathing, or stops breathing all together, while asleep.
- Conditions
- Pediatric Sleep Apnea, Obstructive Sleep Apnea, Tonsils Hypertrophy
- Trial name
- NCT05459935
- Testing
- PBM Tonsil Arm
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Premature Birth, Respiratory Distress Syndrome
Non-invasive Ventilation in Preterm Infants
This is a prospective, observational cohort study. For the study part on noninvasive neurally adjusted ventilatory assist (NIV-NAVA) the design is interventional.
- Conditions
- Premature Birth, Respiratory Distress Syndrome, Ventilator Lung; Newborn
- Trial name
- NCT05987800
- Testing
- Titration procedure, Electrical impedance tomography, Lung and diaphragm ultrasound
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- Universitair Ziekenhuis Brussel
Sickle Cell-hemoglobin SS Disease, Vaso-occlusive Crisis
Non Invasive Positive Pressure Ventilation for Prevention of Acute Chest Syndrome in Sickle Cell Disease
Acute chest syndrome is a severe respiratory complication of sickle cell disease. The standard prevention of this dangerous complication is spirometry in wich patient is required to take deep breaths trough a little device…
- Trial name
- VPACS (NCT01501643)
- Testing
- Non invasive positive pressure ventilation, Spirometry
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure
A Pilot Study of Synchronized and Non-invasive Ventilation ("NeuroPAP") in Preterm Newborns
There is currently a consensus that non-invasive ventilation (NIV) in preterm infants is preferred over intubation. There are two ways of delivering NIV in preterm infants, nasal continuous positive airway pressure (CPAP) or…
- Trial name
- NeuroPAP (NCT02480205)
- Testing
- NeuroBox to deliver the NeuroPAP
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital