Clinical trials: Non-operative Treatment
Appendicitis, Surgery
Raja Isteri Pengiran Anak Saleha Appendicitis Treatment Without Operation
The RIPASA score is a Clinical Prediction Rule (CPR) for the diagnosis of acute appendicitis. Since its inception in 2009, the RIPASA score has been validated in various population in healthcare institutions around the world and…
- Trial name
- RIPASA-TWO (NCT03169114)
- Testing
- Amikacin Injection, Appendicectomy
- Where
- Brunei
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Raja Isteri Pengiran Anak Saleha Hospital
Pectus Excavatum, Pectus Carinatum
Physiological Assessments During Non Operative Treatment on the Chest Wall Deformities
The physiological assessment in non-operative treatment on chest wall deformities, are still unclear today. These functional benefits outweigh the aesthetic benefits associated with anatomical improvement.
- Trial name
- PECTUS (NCT02528656)
- Testing
- Vacuum Bell, Dynamic Compression System
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fracture, Trauma
Surgical Treatment Versus Non-surgical Treatment of Ulnar Fractures
The purpose of this study is to determine if surgery using a plate and screws to fix a forearm fracture (ulnar shaft) will improve functional outcome compared to non-operative treatment out to 1 year of follow-up.
- Conditions
- Fracture, Trauma, Ulna Fracture, Orthopedic
- Trial name
- NCT01123447
- Testing
- Open reduction and internal fixation, Closed reduction and short-arm cast
- Where
- 9 sites in Canada, United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Clavicle Fractures
Study Comparing Intramedullary Nailing, Plate Fixation, and Non-operative Treatment of Clavicle Fractures
Patients with acute, displaced fractures of the middle third of the clavicle will be randomly assigned into either the non-operative treatment group or the operative treatment group.
- Trial name
- NCT01311219
- Testing
- Non-operative Treatment, Operative Treatment-Plate Fixation, Operative Treatment-Intramedullary Pinning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Shoulder Dislocation
Non-operative Versus Operative Treatment of Acute Acromioclavicular Joint Dislocation
The purpose of this study is to compare non-operative treatment versus operative treatment in patients who suffer a complete, acute acromioclavicular (AC) joint dislocation.
- Trial name
- ACJoint (NCT00594841)
- Testing
- Open Reduction Internal Fixation of AC joint dislocation, Non operative treatment of AC joint dislocation (sling)
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Unity Health Toronto
Lateral Malleolus Fracture
A Noninferiority RCT Comparing Operative vs Nonoperative Treatment for ER-stress Positive Weber-B Unimalleolar Fractures
Current gold standard treatment for unstable (those found unstable in external rotation (ER) stress testing Weber B-type, Lauge-Hansen supination-external rotation type IV) ankle fractures is open reduction and internal fixation…
- Trial name
- NCT01758796
- Testing
- Non-operative treatment, Surgery
- Where
- Finland
- Volunteers
- 126 people
- Sponsor
- University of Oulu
Head and Neck Cancer, Non-melanomatous Skin Cancer
Radiation Therapy in Treating Patients With Head and Neck Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which regimen of radiation therapy is more effective for head and neck cancer.
- Trial name
- NCT00021125
- Testing
- adjuvant therapy, radiation therapy
- Where
- United Kingdom
- Volunteers
- 460 people
- Sponsor
- Medical Research Council
Appendicitis
Appendectomy Versus Non-Operative Treatment For Acute Non-Perforated Appendicitis in Children
Rationale and Aim: The standard treatment for acute appendicitis in children is appendectomy. An increasing body of evidence from the adult literature suggests that acute appendicitis may be treated effectively with antibiotics…
- Trial name
- APPY (NCT02687464)
- Testing
- Non-operative treatment, Appendectomy
- Where
- United States
- Volunteers
- 978 people
- Sponsor
- Children's Mercy Hospital Kansas City
Humerusshaft Fractures
Non Randomized Humerusshaft Fracture
The aim of the study is to radiologically compare the fracture healing as well as the functional treatment outcome of conservative and operative treatment of defined humerusshaft fractures after 6w./12w./and 12 month based on the…
- Trial name
- NCT00205972
- Testing
- Humerus Nail or LC Plate
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Rectal Cancer
Planned Non-operative Management for Rectal Cancer
The investigators propose to conduct an observational study on consecutive patients with low-lying or mid rectal cancers smaller than 5 cm in length and less than 50% of rectal circumferential extent.
- Trial name
- NCT05241574
- Testing
- Radiotherapy boost, Additional consolidation chemotherapy
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Appendicitis
Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children
OBJECTIVE The aim of this study is to compare the effectiveness of initial non-operative treatment strategy (reserving appendectomy for those not responding or with recurrent disease) with immediate appendectomy in children from…
- Trial name
- APAC (NCT02848820)
- Testing
- Augmentin + Gentamicin, Appendectomy
- Where
- 15 sites in Netherlands
- Volunteers
- 302 people
- Sponsor
- Ramon Gorter
Gastrocutaneous Fistula, Gastrostomy Complications
A Prospective Evaluation of Non-Operative Treatments for Gastrocutaneous Fistulae in Children
Gastrostomy tube placement is a common surgery, and involves placing a tube from the child's skin to the inside of their stomach, allowing an alternative route for nutrition and medication to patients who cannot tolerate oral…
- Trial name
- GCF (NCT03920306)
- Testing
- oral anti-acid treatment
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Clavicle Fracture
Multi-Center Adolescent Clavicle Fracture Trial: Operative vs. Non-Operative Treatment
Investigators from eight tertiary care, level 1 pediatric trauma centers have developed a protocol for the establishment of a formal, prospective multi-center adolescent clavicle registry, with designs for standardized…
- Trial name
- FACTS (NCT04250415)
- Testing
- Surgery
- Where
- 8 sites in United States
- Volunteers
- 250 people
- Sponsor
- Boston Children's Hospital
Acromioclavicular Joint, Dislocation
A Prospective, Randomised Long-term Follow-up of Operative Versus Non-operative Treatment of Gr. 3 Acromioclavicular Dislocation
The purpose of this study is to compare the long-term clinical and radiological results of operative and conservative treatment of Tossy type 3 acromio-clavicular dislocation.
- Conditions
- Acromioclavicular Joint, Dislocation, Surgical Procedures, Operative
- Trial name
- NCT00840593
- Testing
- Non-surgical group, Surgical group
- Where
- Finland
- Volunteers
- 39 people
- Sponsor
- Kuopio University Hospital
Lower Abdominal Pain, Right Iliac Fossa Pain
Non Operative Treatment for Acute Appendicitis
Case control studies that randomly assign patients to either surgical or non-surgical treatment yield a relapse rate of approximately 14% at one year.
- Conditions
- Lower Abdominal Pain, Right Iliac Fossa Pain, Acute Appendicitis
- Trial name
- NOTA (NCT01096927)
- Testing
- Amoxicillin and Clavulanic Acid
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Maggiore Bellaria Hospital, Bologna
Patellar Dislocation
Non-operative Treatment in First-time Patellar Dislocation
Study to evaluate the conservative treatment of patients after their first episode of primary lateral patellar dislocation. Randomized controlled trial with 2 groups: standard treatment (2-weeks with brace) followed by physical…
- Trial name
- NCT06086080
- Testing
- Standard care, Taping
- Where
- Colombia
- Volunteers
- 50 people
- Sponsor
- Fundacion Clinica Valle del Lili
Acute Appendicitis
Non-operative Treatment of Acute Non-perforated Appendicitis
Gold Standard treatment of appendicitis is appendectomy but non-operative treatment of non-perforated appendicitis with antibiotics is also under trial.
- Trial name
- NCT04030741
- Testing
- Meronem and flagyl, Appendectomy
- Where
- Pakistan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University
Esophageal Cancer, Gastric Cancer
Combination Chemotherapy Plus Radiation Therapy With or Without Fluorouracil in Treating Patients With Cancer of the Esophagus or Stomach
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00009880
- Testing
- filgrastim, cisplatin, fluorouracil
- Where
- 66 sites in United States
- Sponsor
- Radiation Therapy Oncology Group
Pilonidal Disease
Comparing Operative vs Non Operative Treatment for Pilonidal Disease
The goal is to evaluate whether surgical excision of the pilonidal disease is needed after resolution of the initial symptoms when the patient follows regular hair removal regimen such as laser epilation.
- Trial name
- NCT05439291
- Testing
- Regular Epilation Regimen, Surgical excision
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Stanford University
Lung Cancer
Surgery With or Without Preoperative Chemotherapy in Treating Patients With Resectable Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if surgery is more effective with or without preoperative chemotherapy in treating…
- Trial name
- NCT00003159
- Testing
- carboplatin, cisplatin, docetaxel
- Where
- 2 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- Medical Research Council