Clinical trials: Obstetric Bleeding
Postpartum Hemorrhage
RUBY Post-Market Registry on the Jada® System
The RUBY Study is a multicenter, observational, post-market registry designed to collect observational data on patients treated with the Jada System in the post-market setting.
- Trial name
- RUBY (NCT04995887)
- Testing
- Jada® System
- Where
- 16 sites in United States
- Volunteers
- 809 people
- Sponsor
- Alydia Health
Umbilical Cord
Timing of Umbilical Cord Clamping: One to Three Minutes vs. After Cessation of Cord Pulsation
The timing of umbilical cord clamping has been widely discussed in the scientific community. As part of the worldwide strategies to reduce childhood iron deficiency anemia, the incorporation of late clamping (at least one minute…
- Trial name
- CORD (NCT03844490)
- Testing
- CESSATION OF CORD PULSE, CONTROL
- Where
- Brazil
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Uterine Bleeding, Atony, Uterine
Questionnaire for Obstetricians and Anesthesiologist
The research was planned as a face-to-face survey evaluation. The questionnaire will be applied to obstetricians and anesthesiologists working in public and private hospitals.
- Conditions
- Uterine Bleeding, Atony, Uterine, Cesarean Section Complications
- Trial name
- NCT05089721
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Gazi University
Post Partum Hemorrhage
Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage
Post partum Hemorrhage (PPH) is one of three main causes of death in pregnant women. Oxytocin is widely used for prevention of PPH. Some studies suggested misoprostol as an alternative treatment when Oxytocin isn't available.
- Trial name
- NCT01863706
- Testing
- Misoprostol, Oxytocin
- Where
- Iran
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hormozgan University of Medical Sciences
Postpartum Hemorrhage
Buccal Misoprostol During Cesarean Section for Preventing Postpartum Hemorrhage
Objective: to demonstrate that buccal misoprostol administration during cesarean delivery in women with risk factors for uterine atony decreases the need for additional uterotonic medications, uterine atony and postpartum…
- Trial name
- NCT01733329
- Testing
- Misoprostol, Folic Acid
- Where
- Mexico
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Post-partum Hemorrhage (PPH)
Accurate Display of Postpartum Hemorrhage Using Triton (ADOPT)
A comparison of reported estimated blood loss with quantified blood loss in all patients whose medical records indicate Triton was used during their vaginal delivery.
- Trial name
- ADOPT (NCT02981758)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hackensack Meridian Health
Postpartum Hemorrhage
Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization: an In-vitro Analysis of Oxytocin Receptor Expression and Signaling
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality and morbidity worldwide, and is caused most commonly by poor uterine muscle contraction after delivery of the baby and placenta.
- Trial name
- NCT02762669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage, Postsurgical Bleeding
Abdominal Ultrasound Assessment in the Post-cesarean Patient
This study is designed to see if abdominal ultrasound after planned cesarean delivery can identify women with ongoing intra-abdominal bleeding.
- Conditions
- Postpartum Hemorrhage, Postsurgical Bleeding, Abdominal Ultrasound, FAST Scan
- Trial name
- NCT02159105
- Testing
- FAST scan and non-invasive hemoglobin measurement
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Infant, Very Low Birth Weight, Infant, Premature
Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)
This trial was to determine whether giving low-dose indomethacin to infants weight 500 to 999 grams (approximately 1 to 2 pounds) at birth improves their survival without cerebral palsy or developmental problems at 18 to 22…
- Conditions
- Infant, Very Low Birth Weight, Infant, Premature, Ductus Arteriosus, Patent
- Trial name
- TIPP (NCT00009646)
- Testing
- indomethacin
- Where
- 9 sites in United States
- Volunteers
- 1,202 people
- Sponsor
- NICHD Neonatal Research Network
Postpartum Hemorrhage
Video Debriefing at the Delivery Ward
Postpartum hemorrhage continues to be the leading cause of maternal morbidity and mortality worldwide. Successful management of postpartum hemorrhage requires not only administration of the right medicine, but also a rapid and…
- Trial name
- NCT04646486
- Testing
- Video debriefing
- Where
- 2 sites in Denmark
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hemorrhage, Premature Infants
NIRS Monitoring in Premature Infants
This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for…
- Conditions
- Hemorrhage, Premature Infants, Newborn, Hydrocephalus
- Trial name
- NCT02601339
- Testing
- ETV/CPC
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cesarean Section Complications, Postpartum Hemorrhage
Perioperative Outcomes of Postpartum Hemorrhage in Patients Undergoing Cesarean Delivery
Postpartum haemorrhage is the common cause of maternal death worldwide. The primary purpose of this study is to identify the maternal outcomes after PPH.
- Conditions
- Cesarean Section Complications, Postpartum Hemorrhage, Anesthesia Complication, Blood Transfusion Complication
- Trial name
- NCT04833556
- Where
- Thailand
- Volunteers
- 649 people
- Sponsor
- Mahidol University
Postpartum Hemorrhage, Venous Thromboembolism
Haemorrhages and Thromboembolic Venous Disease of the Postpartum
The aim of this study is to evaluate the frequencey and the determinants of postpartum major complications (hemorrhage and thrombosis) up to 3 months after delivery in the maternity hospitals of Finistère (Bretagne - France)
- Trial name
- HEMOTHEPP (NCT02443610)
- Where
- 6 sites in France
- Volunteers
- 20,241 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Postpartum Hemorrhage
Misoprostol for Preventing Postpartum Hemorrhage
This hospital-based, multicenter, randomized, placebo-controlled trial will assess the effects of misoprostol as part of active management of the third stage of labor on postpartum blood loss, complications, and side effects.
- Trial name
- NCT00124540
- Testing
- misoprostol
- Where
- 5 sites in Nigeria, South Africa and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Preterm Birth
Preterm Infant Transport Stress (PremiTranS) Study
This is an observational pilot study to quantify the amount of vibration, noise, physiological and biochemical instability that premature babies are exposed to during inter-hospital transport.
- Trial name
- PremiTranS (NCT01851668)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Postpartum Hemorrhage
Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section
Postpartum hemorrhage (PPH) is a common complication of childbirth and a leading cause of maternal morbidity and mortality. The prompt and effective treatment of subjects with PPH would reduce operation risks.
- Trial name
- NCT02079558
- Testing
- Carbetocin, Oxytocin
- Where
- Iran
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Pregnancy Complications, Maternal Death
Nutrition Optimalization Among Pregnant Women to Improve Maternal and Neonatal Outcome in DKI Jakarta
The goal of this MONAS Study is to learn about comprehensive monitoring and nutritional intervention among pregnant women in order to improve maternal and neonatal outcomes. The main questions it aims to answer are: 1.
- Conditions
- Pregnancy Complications, Maternal Death, Preeclampsia, Intrauterine Infection
- Trial name
- MONAS (NCT06268509)
- Testing
- Nutritional panel laboratory examination, Pregnancy supplements (other than provided by Ministry of Health), Fetomaternal ultrasound
- Where
- Indonesia
- Volunteers
- 245 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Postpartum Hemorrhage
Misoprostol in the Prevention of Postpartum Haemorrhage
Postpartum haemorrhage is a major contributor to maternal mortality in the developing world. The incidence is between 5 and 12% in Jamaica and varies depending on the route of delivery.
- Trial name
- NCT04044287
- Testing
- 200 micrograms of misoprostol
- Where
- Jamaica
- Volunteers
- 1,496 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Postpartum Hemorrhage
Misoprostol and Oxytocin in Uniject® for Postpartum Hemorrhage Prevention in Communities
This community-based cluster Randomised Control Trial will assess the feasibility, cost, risks and benefits of use of oral Misoprostol and parenteral Oxytocin in Uniject® as prophylaxis for postpartum hemorrhage (PPH) in…
- Trial name
- NCT01710566
- Testing
- Misoprostol, Oxytocin
- Sponsor
- Gynuity Health Projects
Premature Infants, Intracranial Hemorrhages
Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome
Preterm and very preterm infants are at risk of developing encephalopathy of prematurity and long-term neurodevelopmental delay.
- Conditions
- Premature Infants, Intracranial Hemorrhages, Periventricular Leukomalacia, Cerebral Palsy
- Trial name
- NCT03110341
- Testing
- Erythropoietin, Normal saline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University