Clinical trials: Obstructive Airway Diseases
Asthma
Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
The purpose of this study is to compare the effects of 2 weeks therapy of montelukast, budesonide, their combination on exercise induced bronchoconstriction (EIB) and airway inflammation in children and young adults, not on…
- Trial name
- NCT00462592
- Testing
- budesonide, montelukast
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- Hamilton Health Sciences Corporation
Snoring, Apnea, Obstructive
Dental Appliance to Treat SDB in Children
The clinical hypothesis of this study is that a currently marketed mouthguard may also be able to reduce the symptoms of sleep-disordered breathing in children.
- Conditions
- Snoring, Apnea, Obstructive, Upper Airway Resistance Syndrome, Sleep-Disordered Breathing
- Trial name
- NCT05661747
- Testing
- Vivos Grow/Vivos Way Device
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Vivos BioTechnologies, Inc.
Sleep Apnea, Obstructive
Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea
The purpose of this research study is to examine the effects of two commonly used anesthetic drugs, dexmedetomidine and propofol, have on the shape and muscle tone of the upper airway in children, adolescents, and young adults…
- Trial name
- NCT01344759
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma, Healthy
Factors Involved in Asthma and Airway Inflammation
Asthma is the third leading cause of preventable admissions to the hospital in the United States. Deaths and diseases associated with asthma increase every year. Asthma is a disorder of airway inflammation.
- Trial name
- NCT00001887
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma
Modulation Of Airway Reactivity With Chronic Mechanical Strain
The purpose of this study is to see if the use of a machine called CPAP will help children with asthma breathe better. CPAP is a machine that produces airflow to help people with breathing problems.
- Trial name
- NCT02396849
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Indiana University
Community Acquired Pneumonia, Bronchiolitis
HVNI vs CPAP in Children With Acute Respiratory Distress
Acute breathing problems are a common reason for children to be admitted to the pediatric intensive care unit, and many of these children need breathing support without a breathing tube.
- Trial name
- P-HVNI-CPAP (NCT07336121)
- Testing
- High Velocity Nasal Insufflation (HVNI), Nasal Continuous Positive Airway Pressure (Nasal CPAP)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Sleep Apnea, Obstructive, Sleep Apnea Syndromes
Continuous Positive Airway Pressure (CPAP) After Adenotonsillectomy in Children
Obstructive sleep-disordered breathing (SDB) affects 2-3% of children and may lead to problems with nighttime sleep and daytime behavior, learning, sleepiness, and mood.
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea Syndromes, Child Behavior Disorders, Attention Deficit Disorder With Hyperactivity
- Trial name
- NCT01554527
- Testing
- CPAP treatment, No CPAP treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Michigan
Asthma
Development of a Breath Analyzer for Asthma Screening
Annually, asthma is responsible for 1 million emergency room visits, 400,000 hospitalizations, and 5000 deaths according to the NHLBI.
- Trial name
- NCT00386737
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ekips Technologies
Asthma
Assessment Of The Effects Of Short and Long Term Use Of CPAP
We hypothesize that the nocturnal use of continuous positive airway pressure in adults and children with asthma will decrease airway reactivity.
- Trial name
- NCT00592631
- Testing
- CPAP-Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Indiana University
Asthma
Role of Airway Hyperresponsiveness on Performance in Elite Swimmers.
The prevalence of airway hyperresponsiveness (AHR) is very high in elite swimmers, reaching 80% in certain studies. Repeated Chlorine-derivatives exposure may be a major causative factor for its development.
- Trial name
- NCT00876135
- Testing
- Ventolin
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- Laval University
Asthma
Asthma and Allergy Screening AA2000 (Cross Sectional)
Asthma screening of 493 asthma patients
- Trial name
- AA2000 (NCT04727112)
- Testing
- Usual care versus primary care
- Volunteers
- 493 people
- Sponsor
- Bispebjerg Hospital
Asthma
Usefulness of Exhaled Breath Condensate for Evaluation of Markers of Airway Inflammation in Children With Asthma
Exhaled breath condensate (EBC) has emerged as a novel noninvasive technique for assessment of airway inflammation, and it provides information on airway lining fluid composition.
- Trial name
- NCT00961155
- Testing
- cyklezonid, montelukast sodium, formoterol 12 mcg twice daily
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Down Syndrome, Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome
Many individuals with Down syndrome (DS) have breathing problems during sleep. This is called obstructive sleep apnea syndrome (OSAS).
- Trial name
- TRIO (NCT01808508)
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospital of Philadelphia
Bronchiolitis
Treatment of Pediatric Bronchiolitis
Bronchiolitis (BQ) is the acute viral infection of the tract respiratory syndrome in infants that affects the bronchioles of babies under 24 months of age.
- Trial name
- NCT03835936
- Testing
- High frequency compression of the chest wall group, Manual maneuvers physiotherapy group
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Guadarrama Hospital
Uncontrolled Asthma
A Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents With Uncontrolled Asthma
A 52-Week, Multicentre, Randomized, Double-Blind, Parallel Group, Placebo Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Tralokinumab in Adults and Adolescents with Asthma Inadequately Controlled on Inhaled…
- Trial name
- STRATOS1 (NCT02161757)
- Testing
- Tralokinumab
- Where
- 243 sites in United States, Argentina and 13 more
- Volunteers
- 1,207 people
- Sponsor
- AstraZeneca
Cystic Fibrosis, Pulmonary Disease, Chronic Obstructive
Comparison of Two Treatment Regimens to Reduce PA Infection in Children With Cystic Fibrosis
Cystic fibrosis (CF) is a chronic disease that significantly affects an individual's lung function. Antibiotic medications have been proven effective at reducing Pseudomonas aeruginosa (PA) infection, which is one of the main…
- Trial name
- EPIC (NCT00097773)
- Testing
- Tobramycin solution for inhalation (TOBI), Oral ciprofloxacin
- Where
- 54 sites in United States
- Volunteers
- 304 people
- Sponsor
- Seattle Children's Hospital
Asthma, Lung Diseases, Obstructive
Genetics of Airway Responsiveness and Lung Function
To perform a genome-wide search for genes affecting two phenotypes related to asthma and chronic obstructive pulmonary disease (COPD) in a Chinese population.
- Conditions
- Asthma, Lung Diseases, Obstructive, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00005537
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma
Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics
Bronchial asthma is a common chronic respiratory disease. Patients usually manifest variable symptoms (such as short of breath, chest tightness, cough, etc.) and variable airflow limitation and often associated with airway…
- Trial name
- NCT02574975
- Testing
- methacholine, adenosine monophosphate, leukotriene D4
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhujiang Hospital
Asthma
Effects of Montelukast in Children With Asthma
Leukotriene receptor antagonists (LTRAs) reduce fractional exhaled nitric oxide (FENO) concentrations in children with asthma, but the effect of LTRA withdrawal on FENO and lung function is unknown.
- Trial name
- NCT00675285
- Testing
- montelukast sodium
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Catholic University of the Sacred Heart
Asthma, COPD
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
- Conditions
- Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders
- Trial name
- AWARE (NCT06512064)
- Testing
- AWARE
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Indiana University