Clinical trials: Obstructive Ventilation Disorder
Asthma
Safety Study in Adolescent and Adult Patients With Asthma
E004-C2 is a continuation of E004-C for safety evaluations with additional 3 months to be able to assess the 6-month safety profile for E004 (epinephrine inhalation) versus placebo in a double-blinded manner.
- Trial name
- NCT01476904
- Testing
- Primatene Mist, Epinephrine inhalation
- Where
- 27 sites in United States
- Volunteers
- 208 people
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Cardiac Diseases, Muscular Weakness
Biomarker for Pompe Disease (BioPompe)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Pompe disease from blood (plasma)
- Conditions
- Cardiac Diseases, Muscular Weakness, Hepato-splenomegaly, Lung Disease
- Trial name
- BioPompe (NCT01457443)
- Where
- 4 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
Obstructive Sleep Apnea, Child, Only
Study of Postoperative Respiratory Complications in Children With Obstructive Sleep Apnea (PORC)
Adenotonsillectomy is the first line surgical treatment for children with Obstructive Sleep apnea Syndrome (OSAS). Postoperative respiratory complications (PORC) may occur and are often related to co-morbidities.
- Conditions
- Obstructive Sleep Apnea, Child, Only, Surgery
- Trial name
- PORC (NCT05308108)
- Testing
- (Adeno)tonsillectomy
- Where
- Belgium
- Volunteers
- 132 people
- Sponsor
- University Hospital, Antwerp
Fever, COPD
The Application of a Wireless Sensor Technology for Vital Statistics in CHILDREN AND ADULTS
The primary outcome for this project will be the development of a small, non-invasive wireless sensor that is linked to a conventional computer that can be used in health care for monitoring of acute and chronic health problems.
- Conditions
- Fever, COPD, Obesity, Congenital Heart Disease
- Trial name
- NCT01845506
- Testing
- Cardiorespiratory monitor, Wireless pressure sensor
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
OSA, Sleep Apnea
Comparison of Standing Versus Supine 3D Cone Beam Computed Tomography in Patient With Obstructive Sleep Apnea
The anatomical changes of the upper airway in a standing vs pseudo-supine position using Carestream Orthodontic Imaging (Volumetric) and Carestream Orthodontic Imaging module (AP measurements) of the patient's airway…
- Trial name
- OSA (NCT04874727)
- Testing
- Mandible slacked and captured with Correct Plus™ Impression Material Superfast
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Manhattan Beach Orthodontics
Sleep Apnea, Obstructive
Pediatric Obstructive Sleep Apnea Diagnosis by Respiratory Polygraphy
Respiratory polygraphy (RP) can be used to detect obstructive sleep apnea syndrome in children (OSA) , but it underestimates the obstructive apnea-hypopnea index (OAHI) because hypopneas associated with cortical arousals are not…
- Trial name
- NCT06754800
- Testing
- Polysomnography in routine care
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Central Hospital, Nancy, France
Pregnant Women
Fetal Outcome of Sleep Disordered Breathing During Pregnancy
Sleep disordered breathing (SDB) is a frequent disorder characterized by some combination of repeated events of partial or complete upper airway obstruction during sleep, disruption of normal ventilation, hypoxemia, and sleep…
- Trial name
- NCT00931099
- Where
- Israel
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Obstructive Sleep Apnea (OSA), Orofacial Myofunctional Disorders
Oromyofunctional Training: an Innovative Rehabilitation Program for Pediatric Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a prevalent medical condition with important implications for overall health and quality of life in both children. Therefore, it is important to treat OSA early and effectively.
- Trial name
- OROFIT (NCT07129967)
- Testing
- Orofacial myofunctional therapy
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- University Ghent
Down Syndrome, Obstructive Sleep Apnea
Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea
This study is a prospective, single-arm study conducted under a common implant and follow-up protocol. The objective will be to follow fifty-seven (57) adolescents and young adults (10-21 years of age), with Down syndrome…
- Trial name
- NCT04801771
- Testing
- Inspire Upper Airway Stimulation (UAS) System
- Where
- 8 sites in United States
- Volunteers
- 57 people
- Sponsor
- Inspire Medical Systems, Inc.
Cardiovascular Diseases, Heart Diseases
Mechanisms Mediating Cardiovascular Disease in Children With Obstructive Sleep Apnea
To identify the early effects of obstructive sleep apnea on the cardiovascular system of children.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Sleep Apnea Syndromes, Lung Diseases
- Trial name
- NCT00059111
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bronchiolitis
Efficacy of Lavender Essential Oil Chest Wraps in Infants With Bronchiolitis
The goal of this clinical trial is to learn if lavender essential oil chest wraps relieve cough in infants with bronchiolitis compared to standard care.
- Trial name
- NCT06108648
- Testing
- Lavender essential oil 10%, diluted in 90% olive oil, Control
- Where
- 2 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
Obstructive Sleep Apnea, Down Syndrome
Medications for Obstructive Sleep Apnea In Children With Down Syndrome
This is a randomized, double blind, cross-over study of the combination of atomoxetine and oxybutynin (ato-oxy) in children with DS and OSA documented by polysomnography (PSG).
- Trial name
- MOSAIC (NCT04115878)
- Testing
- Atomoxetine and oxybutynin (ato-oxy)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Arizona
Tonsillitis Chronic, Tonsillitis Recurrent
The Effect of Systemic Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Vs Intraoperative Infiltration of Steroids in Tonsillar Bed Following Tonsillectomy on Post Tonsillectomy Pain.
The aim of this study is to compare the efficacy of adding paracetamol to systemic non-steroidal anti-inflammatory drugs (NSAIDs) versus adding dexamethasone as local infiltration to paracetamol on post tonsillectomy pain control.
- Conditions
- Tonsillitis Chronic, Tonsillitis Recurrent, OSA - Obstructive Sleep Apnea
- Trial name
- NSAIDs (NCT07035314)
- Testing
- Dexamethasone, NSAIDs, Control (Standard treatment)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Asthma, Sleep Disordered Breathing
Personalized Asthma Care Team
"Individualized health care" refers to the development of strategies for disease management and health promotion that are informed by specific data on genetics and physiological processes that uniquely determine each person's…
- Conditions
- Asthma, Sleep Disordered Breathing, Obesity
- Trial name
- PACT (NCT01423461)
- Volunteers
- 201 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
A Research Study for Children About Heart Changes and Obstructive Sleep Apnea (OSA)
In this research study the investigators want to learn more about the risk of developing blood vessel and heart disease from night-time sleep apnea.
- Trial name
- NCT01837459
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma
Clinical Pharmacology Study of CHF1535 pMDI 50/6 µg Versus The Free Combination In Asthmatic Children 5-11 Years Old
The rationale is to investigate the systemic availability of BDP/B17MP and formoterol after single oral inhalation of CHF 1535 50/6 pMDI vs the free combination of approved BDP and Formoterol pMDIs, in asthmatic children (5 to 11…
- Trial name
- PAED1 (NCT01848769)
- Testing
- CHF1535 pMDI + AC Plus, BDP + AC Plus, Formoterol + AC Plus
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Pulmonary Emphysema, COPD
AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation
The purpose of this study is to characterize the safety and efficacy of the AeriSeal System in patients with advanced upper lobe predominant emphysema and significant collateral ventilation as determined by the Chartis System.
- Conditions
- Pulmonary Emphysema, COPD, Lung Diseases
- Trial name
- CV+ (NCT01460108)
- Testing
- AeriSeal System
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology
Asthma, Child
Buteyko Method for Children With Asthma
This study has the aim to assess the effectiveness of the Buteyko method as an adjunct therapy in the treatment of children with asthma.
- Conditions
- Asthma, Child, Breathing Exercises
- Trial name
- NCT02720380
- Testing
- Buteyko, Asthma education
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Adolescent Behavior, Asthma
Breathing Retraining for Asthma Trial of Home Exercises for Teenagers
This trial will address the impaired quality of life of young people with asthma, despite appropriate medicines. Research shows that young people report needing to calm themselves down during an asthma attack to control their…
- Trial name
- Breathe4T (NCT05006703)
- Testing
- Breathe for Teens (Breathe4T)
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Severe Bronchiolitis, Pediatric Respiratory Distress
NIV-NAVA in Infants With Severe Bronchiolitis, a Pilot Multicenter Randomized Controlled Trial
Severe bronchiolitis is a common lung infection in babies that can cause serious breathing problems and often leads to hospitalization in pediatric intensive care units (PICUs).
- Trial name
- NAVIGATE (NCT07834723)
- Testing
- NIV NAVA
- Where
- 4 sites in Canada
- Volunteers
- 90 people
- Sponsor
- St. Justine's Hospital