Clinical trials: Oesophageal Motility Disorder
Gastroesophageal Reflux
Pre and Post-gastrostomy Evaluation of GER in Children Using 24-hour pH Monitoring
The aim of this study was to evaluate 24-hour pH monitoring results before and after gastrostomy in neurological impaired (NI) children who underwent gastrostomy or Nissen fundoplication (NF) concurrently with gastrostomy.
- Trial name
- NCT04454112
- Testing
- 24-hour esophageal pH monitoring using an ambulatory system (Ohmega, MMS, Enschede, The Netherlands).
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Fatma Demirbaş
Asthma, Gastroesophageal Reflux Disease
Reflux Disease Therapy in the Management of Childhood Asthma-data Entry and Analysis Only
There have been a number of studies which attribute causality between reflux disease and asthma. In addition, clinicians typically treat chronic asthmatics with high dose acid suppressing medications (e.g. lansoprazole).
- Trial name
- NCT01536457
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Children's Center for Digestive Health Care
Gastroesophageal Reflux
Prevalence of Gastroesophageal Reflux During Childhood and Teenage Years in France
The purpose of this study is to assess prevalence of gastrooesophageal reflux during childhood and teenage years in France and to describe patients'symptoms and gastrooesophageal reflux management
- Trial name
- NCT00681837
- Where
- 25 sites in China
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
GERD, Gastroesophageal Reflux
Compassionate Use of Domperidone for Refractory Gastroparesis
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard…
- Conditions
- GERD, Gastroesophageal Reflux, Gastroparesis
- Trial name
- NCT04699591
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jose Cocjin
Gastroesophageal Reflux, Infant, Newborn, Diseases
Treatment of Gastroesophageal Reflux Disease in Infants
Gastroesophageal reflux disease in infants is not fully understood. Infants are prescribed medical treatments that may not be effective or that contribute to adverse side effects and lead to concerns and expenses for the parents…
- Trial name
- NCT06255886
- Testing
- Protein pump inhibitor., Mother or infant diet
- Where
- 3 sites in Denmark
- Volunteers
- 96 people
- Sponsor
- Odense University Hospital
Gastroesophageal Reflux Disease (GERD)
Safety of Daily Dose Esomeprazole for GERD for Pediatric and Adolescent Patients
This study is a phase III, multi-centre, randomized, double-blind study to assess the safety and tolerability of once daily treatment with esomeprazole 20 or 40 mg in pediatric and adolescent patients 12 to 17 years of age…
- Trial name
- NCT00241501
- Testing
- Esomeprazole (Nexium)
- Where
- 40 sites in United States, Canada and 2 more
- Volunteers
- 140 people
- Sponsor
- AstraZeneca
Gastro Esophageal Reflux
Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)
This study aims to determine the prevalence of symptomatic gastroesophageal reflux disease (GERD) in children aged 8-9 years and 12-13 years in the Czech Republic.
- Trial name
- Czech GERDKids (NCT07482969)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Motol
Gastroesophageal Reflux, Apnea
Study of Erythromycin in GER-Associated Apnea of the Newborn
To evaluate the relationship of reflux and apnea and to determine whether the administration of erythromycin improves the incidence of GER and GER-associated apnea, bradycardic and/or desaturation events in a prospective…
- Conditions
- Gastroesophageal Reflux, Apnea, Bradycardia
- Trial name
- SEGAN (NCT01825473)
- Testing
- Erythromycin, Multi-channel intra-luminal impedance (MII) pH monitoring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Gastroesophageal Reflux
Clinical Trial Comparing Open and Laparoscopic Nissen Fundoplication in Children
The purpose of this study is to determine whether short- and long-term outcomes are different between open and laparoscopic Nissen fundoplication performed in children younger than 2 years of age.
- Trial name
- NCT00382850
- Testing
- Nissen fundoplication
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Johns Hopkins University
Esophageal Achalasia
Quality of Life After POEM for Achalasia
Achalasia is an esophageal motility disorder, characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis.
- Trial name
- NCT05010889
- Testing
- Peroral endoscopic myotomy (POEM)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Gastroesophageal Reflux
Open Label Safety Study of Enteric-Coated Spheroid Suspension in Infants Aged Less Than 12 Months With Presumed Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to provide additional information on safety and tolerability after multiple does of pantoprazole. Only patients who successfully completed the 3001B3-331 study (NCT00362609) or 3001B3-333 study…
- Trial name
- NCT00868296
- Testing
- pantoprazole
- Where
- 71 sites in United States, Australia and 9 more
- Volunteers
- 58 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Gastroesophageal Reflux Disease
Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules in Treating Symptomatic Non-Erosive Gastroesophageal Reflux Disease in Adolescents
The purpose of this study was to assess the safety and effectiveness of once daily oral administration of dexlansoprazole delayed-release capsules in adolescent participants with symptomatic non-erosive gastroesophageal reflux…
- Trial name
- NCT01642602
- Testing
- Dexlansoprazole
- Where
- 64 sites in United States, Belgium and 6 more
- Volunteers
- 104 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease
Neonatal Gastro-Esophageal Reflux Disease (GERD) Management Trial
The overall purpose of the investigator's study is to evaluate the causes of and treatment for feeding difficulty in infants with Gastro-esophageal Reflux Disease (GERD). New treatments can be possible only if the cause is known.
- Trial name
- GMT (NCT02486263)
- Testing
- Study Arm - acid suppression plus feeding bundle, Conventional arm - acid suppression only
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Sudarshan Jadcherla
Achalasia, Alacrima
Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients
The AAAS gene has been known to cause achalasia, alacrima, adrenal abnormalities and a progressive neurological syndrome. A considerable proportion of achalasia patients have been known to show alacrima (decreased secretion of…
- Trial name
- AAAS (NCT00856921)
- Volunteers
- 19 people
- Sponsor
- Asan Medical Center
Cough, COPD
Acoustic Cough Monitoring for the Management of Patients With Known Respiratory Disease
This study pretends to evaluate the potential use of Hyfe Cough Tracker (Hyfe) to screen for, diagnose, and support the clinical management of patients with respiratory diseases, while enriching a dataset of disease-specific…
- Conditions
- Cough, COPD, GERD, Asthma
- Trial name
- NCT05042063
- Testing
- Hyfe Cough Tracker, Hyfe Air
- Where
- Spain
- Volunteers
- 616 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Cerebral Palsy, GERD
Placebo Controlled Study of Baclofen for GERD in Children With Cerebral Palsy
Despite the use of proton pump inhibitors and available prokinetics, medical therapy is ineffective in an important number of children with cerbreal palsy (CP) and gastroesophageal reflux disease (GERD), and failure of medical…
- Trial name
- NCT01386255
- Testing
- Baclofen
- Where
- United States
- Sponsor
- Boston Children's Hospital
Oesophageal Motility Disorder
Correlation Between Clinical Signs and High-resolution Manometry Data in Children
High resolution oesophageal manometry (HRM) is the gold standard for the diagnosis of oesophageal motility disorder. Standard esophageal manometry has been replaced since 2000 by high resolution manometry.
- Trial name
- NCT03662490
- Testing
- High resolution oesophageal manometry
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Gastroesophageal Reflux, Regurgitation
Prospective, Comparative, Randomized, Controlled Trial on the Efficacy of the Treatment of Gastroesophageal Reflux Infant With Magnesium Alginate
The results on the efficacy of the formulations based on alginic acid are controversial. Corvaglia et al demonstrated a significant reduction in reflux episodes in preterm infants by evaluation with pH-impedance analysis.
- Conditions
- Gastroesophageal Reflux, Regurgitation, Vomiting, Chronic Cough
- Trial name
- NCT01858584
- Testing
- Gastrotuss, thickened milk
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Federico II University
Sequelae of; Infection, Post Infection Glomerulonephritis
Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2
Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period.
- Conditions
- Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder)
- Trial name
- sequelae (NCT04846010)
- Testing
- PurWet, FurFat, PurApo
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- All Natural Medicine Clinic, LLC
Esophageal Motility Disorders, Gastro-esophageal Reflux
Pressure and Flow Study Before and After Treatments for EMD. The pFlow Study
Pressure and flow (PF) analysis allow a detailed report on the bolus passing for each segment of the esophagus. This approach has evidence in oropharyngeal dysphagia, post reflux surgery dysphagia, gastroesophageal reflux in…
- Trial name
- pFlow (NCT03904004)
- Testing
- Peroral endoscopic myotomy, Neumatic dilatation, Botulinum toxin injection
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion Miguel Servet