Clinical trials: Olfaction
Weight, Birth, Premature Birth
Effects of Olfactory and Gustatory Stimulus on the Nutrition of Premature Babies
The objective of this clinical trial is to test the effects of olfactory and taste stimulation with milk or water in premature newborns with a gestational age between 28 and 32 weeks.
- Trial name
- NCT06305052
- Testing
- Milk, Water
- Where
- Brazil
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Long COVID, Long Covid19
Stellate Ganglion Block to Treat Long COVID 19 Case Series
An assessment of the effectiveness of Stellate Ganglion Block in alleviating symptoms of Long COVID-19.
- Conditions
- Long COVID, Long Covid19, Post-COVID-19 Syndrome, Post Acute COVID-19 Syndrome
- Trial name
- NCT05812209
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Metamorphosis LTD
Fetal Ethmoidal Mucosa
Search for Olfactory Cells Within the Fetal Ethmoid Epithelium
The recent rhinological functional approach known as "Evo-Devo" leads us to consider the nose not as a single organ, but as the construction of a specifically olfactory organ within which functional respiratory structures have…
- Trial name
- COEF (NCT06260657)
- Testing
- Histological analysis on fetal ethmoids
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Newborn; Vitality, Pain
The Effect of Mother's Smell and Breast Milk Smell on Pain
The research was planned as a randomized controlled study to investigate the effect of breast milk smell and mother's smell applied while heel blood was taken to term babies in the Mersin City EAH Neonatal Intensive Care Unit…
- Conditions
- Newborn; Vitality, Pain, Crying
- Trial name
- NCT06323551
- Testing
- Mother's Smell, Mother's Breast Milk Smell
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Tarsus University
Anorexia Nervosa
Impact of an Olfactory Sensory Therapeutic Group for Adolescent Patients With Restrictive Anorexia Nervosa , Pilot Study
Anorexia nervosa is a severe eating disorder of multifactorial origin and for which there is, to date, no specific, standardized and protocolized management for anorexic patients or data on the superiority of anorexia.
- Trial name
- Sens'Orality (NCT04883554)
- Testing
- Olfactory therapeutic, Body therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Lenval
Solid Tumor Cancer, Medulloblastoma
Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).
Study in children and adolescents of 177Lu DOTATATE (Lutathera®) combined with the PARP inhibitor olaparib for treatment of recurrent or relapsed solid tumours expressing somatostatin receptors (SSTR) (LuPARPed)
- Conditions
- Solid Tumor Cancer, Medulloblastoma, High Risk Neuroblastoma, High Grade Gliomas
- Trial name
- LUPARPED (NCT06607692)
- Testing
- Olaparib; 177Lu-DOTATATE
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Fundación de investigación HM
Mother Who Has Given Birth to a Singleton Newborn, Mother-newborn Dyad
Olfactory Communication in the First Days of Life: From Chemical Mechanisms to Improved Breastfeeding
For a newborn, locating and latching onto the mother's breast is the foundational social interaction. This pivotal moment not only influences the newborn's survival but also determines the mother's physiological (lactation) and…
- Conditions
- Mother Who Has Given Birth to a Singleton Newborn, Mother-newborn Dyad, Singleton Newborn
- Trial name
- OD-ALL (NCT07616076)
- Testing
- Chemical description of the scent of the breast or a newborn, Breast secretion samples, The newborn and its role in colostrum secretion
- Where
- France
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cystic Fibrosis With Other Manifestations, Sinusitis
Longitudinal Pathogen-colonization in Cystic Fibrosis Airways and Ability to Smell
Aim of the study is to detect the prevalence of chronic rhinosinusitis, pathogen colonization of the lower and upper airways and, in a sub-cohort the sense of smelling in patients with cystic fibrosis.
- Trial name
- NCT00803881
- Testing
- nasal lavage and sputum collection
- Where
- Germany
- Volunteers
- 180 people
- Sponsor
- University of Jena
Apnea of Prematurity, Prematurity
Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants
This trial analyzes the effect of an olfactory stimulation with vanilla or strawberry aroma compared to placebo on desaturations and bradycardia in preterm infants with apnea of prematurity.
- Conditions
- Apnea of Prematurity, Prematurity, Infant, Premature, Diseases
- Trial name
- NOSE (NCT05878925)
- Testing
- Aroma
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Spinal Cord Injury at C5-Th10 Level With Complete Lesion, Spinal Cord Transection
Autologous Bulbar Olfactory Ensheathing Cells and Nerve Grafts for Treatment of Patients With Spinal Cord Transection
The purpose of this experimental therapy is to evaluate the safety and efficacy of transplantation of autologous olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts (ONFs) obtained from the olfactory bulb with…
- Trial name
- NCT03933072
- Testing
- obtaining of autologous human olfactory bulb, autologous sural nerve preparation, production of Glial Neuropatch, microsurgical reconstruction of the transected spinal cord with autologous Glial Neuropatch-nerve bridges
- Where
- Poland
- Volunteers
- 2 people
- Sponsor
- Nicholls Spinal Injury Foundation
Telomere Disease, Telomere Shortening
Nasal Brushing for the Diagnosis and Understanding of Telomeropathies
To date, the diagnosis of telomeropathies is based on telomere length measured in blood cells. However, this type of analysis is not always sufficient because some mutations underlying the development of telomeropathies are not…
- Trial name
- TELOSTIC (NCT05508321)
- Testing
- Nasal brushing, Sniffin' Sticks
- Where
- Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Very Low Birth Weight Infant
Olfactory Stimulation for Very Low Birth Weight Infants
This is a RCT study examining whether odor administration to mothers of very low birth weight infants promotes stabilization of vital signs compared with common nursing care.
- Trial name
- NCT05406804
- Testing
- Olfactory stimulation, Routine nursing care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Dysosmia, Anosmia
Treatment of Pediatric Patients That Lost Sense of Smell Due to COVID-19
This research study is a randomized controlled trial in pediatric and young adult patients who have lost their sense of smell due to COVID-19 viral infection. The goals are: 1.
- Conditions
- Dysosmia, Anosmia, Covid19
- Trial name
- NCT04964414
- Testing
- Smell Retraining, Budesonide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Amanda Stapleton
Post-viral Anosmia, Anosmia
SniffTrain: Effectiveness of Sniff Training in the Treatment of Post-Viral Anosmia
The purpose of this study is to learn whether a structured smell training program (called "sniff training") can help improve sense of smell and quality of life in people who have experienced a reduced or lost sense of smell…
- Conditions
- Post-viral Anosmia, Anosmia, Hyposmia
- Trial name
- NCT07857083
- Testing
- Sniff Training Kits
- Where
- 3 sites in United States
- Volunteers
- 204 people
- Sponsor
- University of Virginia
Anosmia, Ageusia
Investigating Anosmia and Ageusia in COVID-19 Adult Patients in Saudi Arabia
COVID-19 has adversely affected the healthcare system across the world. The world was not prepared for global outbreak of infectious diseases.
- Conditions
- Anosmia, Ageusia, Covid19, Corona Virus Infection
- Trial name
- NCT04388618
- Testing
- NHANES smell and taste tests
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 250 people
- Sponsor
- Princess Nourah Bint Abdulrahman University
Preterm Infant Feeding Outcomes
Effect of Breast Milk Olfactory Stimulation
Breast milk olfactory stimulation will improve preterm infants' outcomes.
- Trial name
- BMOS (NCT06771882)
- Testing
- BMOS technique
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Anorexia
Oxytocin and Incitement to Use Olfactory Stimuli in Restrictive Anorexia Nervosa
This prospective pilot study will compare adolescents with restrictive anorexia nervosa who participated for 3 months at olfactory workshops, patients who did not, and healthy patients.The groups will be evaluated before the…
- Trial name
- NCT02333500
- Testing
- olfactory workshop, other workshop, No intervention
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondation Lenval
Down Syndrome, Cognitive Decline
GnRH Therapy on Cognition in Down Syndrome
Down syndrome (DS) is the most common chromosomal disorder; with the increasing life expectancy, about 80% of DS adults reach age 65 years old.
- Conditions
- Down Syndrome, Cognitive Decline, Alzheimer Disease, Early Onset, Olfaction Disorders
- Trial name
- NCT04390646
- Testing
- GnRH, gonadorelin acetate, 0.9% NaCl
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Nelly Pitteloud
Parkinson Disease, MSA - Multiple System Atrophy
Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease
Clinical diagnosis of Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) is challenging, especially in the early stages.
- Conditions
- Parkinson Disease, MSA - Multiple System Atrophy, Lewy Body Dementia (LBD), Neurodegenerative Disease
- Trial name
- EXTRAORDINARY (NCT06846658)
- Where
- 3 sites in Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Anaplastic Thyroid Cancer, Insular Thyroid Cancer
Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer
This phase I trial is studying the side effects of gefitinib in treating patients with metastatic or unresectable head and neck cancer or non-small cell lung cancer.
- Conditions
- Anaplastic Thyroid Cancer, Insular Thyroid Cancer, Metastatic Parathyroid Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity
- Trial name
- NCT00068497
- Testing
- gefitinib
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)