Clinical trials: Oocyte
Infertility Primary
The Aim of This Study is to Determine if Oocyte Sorting for Group Culture Using an Artificial Intelligence Image Analysis Tool (MagentaTM) Increases the Usable Blastocyst Yield and Subsequent Pregnancy in Patients Undergoing IVF
The aim of this study is to determine if oocyte sorting for group culture using an artificial intelligence image analysis tool (MagentaTM) increases the usable blastocyst yield and subsequent pregnancy in patients undergoing IVF.
- Trial name
- NiOS (NCT06521372)
- Testing
- Magenta AI image analysis tool
- Where
- 3 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Ovation Fertility
Fertility, In Vitro Fertilization
A Study Comparing a Shorter Exposure of Oocyte to Spermatozoa Versus a Standard Incubation on the Live Birth Rate of In-vitro Fertilization Treatment
In vitro fertilization (IVF) treatment is now commonly used to treat infertile couples. During IVF treatment, oocytes and sperm are routinely incubated overnight and this may lead to suboptimal culture conditions because of…
- Trial name
- NCT02534857
- Testing
- a shorter exposure of oocyte to spermatozoa
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Pregnancy
Single-center Prospective Cumulus Cell Test Study
Performing an additional non-invasive oocyte diagnostic test based on cumulus cell gene expression could improve the outcome of the ART cycle
- Trial name
- CC-Test (NCT03659786)
- Testing
- CC-Test
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Trial Comparing hCG Triggering Versus hCG Associated With GnRH Agonist
The purpose of this study is to see whether patients triggered with only human Chorion Gonadotropin (hCG) have higher number of Metaphase II oocytes (MII) and implantation rate than patients triggered with hCG combined with…
- Trial name
- NCT01607203
- Testing
- Decapeptyl Daily, pregnyl
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- AZ Jan Palfijn Gent
Infertility, COVID
Detection of SARS-CoV-2 in Follicular Fluid and Cumulus-oocyte-complexes in COVID-19 Patients
Recently, the world was shaken awake by a pandemic caused by a novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2).
- Conditions
- Infertility, COVID, IVF
- Trial name
- COVID_OFF (NCT04425317)
- Testing
- Blood sample
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- CRG UZ Brussel
Female Patients Aged 5-35 Prior to Systemic Chemotherapy, With Significant Risk of Ovarian Toxicity
Fertility Preservation by Ovarian and Oocyte Cryopreservation
Success rates of cancer treatment have increased significantly resulting in many girls and young women who are treated now and will be cancer survivors. Nevertheless, cancer treatment may result in long term side effects.
- Trial name
- HFPP (NCT00578500)
- Testing
- ovarian transplantation
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Infertility and at High Risk of OHSS
Dual Trigger to Reduce Ovarian Hyperstimulation Syndrome
Gonadotropin releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk…
- Trial name
- NCT02022228
- Testing
- triptorelin, hCG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chenshiling
Infertility
Experience of Pain During Oocyte Retrieval- a Comparison Between Two Aspiration Needles
The purpose of the study is to compare the pain experience between the patients that have had their transvaginal oocytes retrieval with ultrasound guidance performed with reduced single lumen needle (Vitrolife Sweden AB…
- Trial name
- NCT00924885
- Testing
- Swemed Follicle Aspiration Set Reduced Single Lumen, Swemed Follicle Aspiration Set Single Lumen (1.4 mm)
- Where
- 4 sites in Sweden
- Volunteers
- 257 people
- Sponsor
- Vitrolife
Embryo Hypoxia
Influence of Manipulation of Oocytes and Embryos in Low Oxygen Tension on Assisted Reproduction Technology Outcome
Nowadays, most assisted reproduction laboratories attempt to maintain as much as possible ex vivo culture conditions comparable to those in vivo.
- Trial name
- NCT04424784
- Testing
- 5% O2
- Where
- China
- Volunteers
- 1,160 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Infertility (IVF Patients), Ovarian Aging
Egg Quality Assessment
The goal of this observational study is to learn about egg physiology in humans. The main question it aims to answer is if there is an association between egg physiology and egg quality.
- Conditions
- Infertility (IVF Patients), Ovarian Aging, IVF
- Trial name
- NCT06609421
- Testing
- Informative Appointment
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Ovom Care GmbH
Assisted Reproduction
Small Molecule LCDM and GV Oocyte
Immature eggs obtained during the oocyte retrieval cycle are discarded as medical waste because they cannot complete fertilization, but each egg is important for people with poor clinical outcome.
- Trial name
- NCT05356429
- Testing
- Small molecule LCDM
- Volunteers
- 250 people
- Sponsor
- Peking University People's Hospital
Infertility
DUOSTIM and AI: is There a Difference Between Oocyte Performance in the Follicular and Luteal Phases?
In vitro fertilization (IVF) has revolutionized assisted reproductive techniques, bringing hope to thousands of people seeking to fulfill their dream of parenthood.
- Trial name
- NCT06799598
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- Rio de Janeiro State University
Oocyte, Zona Pellucida
To Investigate the Relationship Between the Viscoelastic Properties of the Zona Pellucida of Human Oocyte and the Blastocyst Utilization Rate
In in vitro fertilization (IVF) treatment, oocyte quality is one of the key factors influencing the success rate of fertilization.
- Conditions
- Oocyte, Zona Pellucida, Viscoelastic Property
- Trial name
- NCT06839495
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Inti Labs
Simulation Training, IVf
Benefits of an Oocyte Pickup Simulation Training Program
The primary objective of this study was to evaluate oocyte pick up simulation training program for teaching residents. The secondary objectives were to evaluate resident satisfaction and the overall current state of oocyte pick…
- Conditions
- Simulation Training, IVf, Education
- Trial name
- NCT04130139
- Testing
- oocyte pick up simulator
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Semen Analysis, ICSI
Evaluating the Utility of Implementing Microfluids for Sperm Preparation Compared to Conventional Method of Density Gradient Centrifugation in a PGT-A Program: a Sibling Oocyte Study
In assisted reproductive technology (ART), sperm preparation aims to select the most viable sperm for ICSI. Unlike conventional methods like density gradients or sperm washing, microfluidic techniques mimic natural selection in…
- Conditions
- Semen Analysis, ICSI, PGT-A
- Trial name
- NCT07093619
- Testing
- FERTILE Plus
- Where
- United Arab Emirates
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Pregnancy
Vitrification Versus Spontaneous Conception and Slow- Rate Freezing
Great scientific effort has been made to improve practical as well as economical procedures of modern assisted reproduction. In the last years a shift from the well established method of slow-rate freezing to vitrification of 2PN…
- Trial name
- NCT01088425
- Testing
- Observation
- Where
- Germany
- Volunteers
- 850 people
- Sponsor
- University of Luebeck
IVF, Infertility
Second Ovulation Induction
Studies reported various risk factors for inadequate ovulation induction such as body mass index, low ovarian reserve, low baseline FSH and LH, and previous use of contraception or agonist.
- Trial name
- NCT06502665
- Testing
- Women having had second ovulation induction after failed oocyte pick-up
- Where
- Canada
- Volunteers
- 87 people
- Sponsor
- Clinique Ovo
Preeclampsia (PE) Risk, Oocyte Donation
Preeclampsia and Defective Placentation in Oocyte Donation: Importance of HLA-C and KIR
The IMMUN-OR study aims to study HLA-C/KIR combinations when looking at the risk of development of preeclampsia (PE) in pregnancies after oocyte donation.
- Trial name
- IMMUN-OR (NCT07178652)
- Volunteers
- 2,325 people
- Sponsor
- Universitair Ziekenhuis Brussel
Oocyte Quality Assessment Using Spectrophotometer
The Aim of the Study is to Check Whether Follicular Fluid Evaluation Using a Spectrophotometer Can Differentiate High Quality Oocytes From Low Quality Oocytes. Oocyte Quality Will be Defined Using GDF9, BMP15 and Oocyte Morphology.
The aim of the study is to check whether follicular fluid evaluation using a spectrophotometer can differentiate high quality oocytes from low quality oocytes.
- Trial name
- NCT07329998
- Testing
- Oocyte quality assessment using spectrophotometer
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Fertility Preservation
Oocyte Vitrification for In Vitro Fertilization (IVF) Patients and Women With Fertility Threatening Conditions
Vitrification is a method of cryopreserving tissue for future use. It is widely used to preserve extra, good quality embryos generated from infertility treatments.
- Trial name
- NCT01448460
- Volunteers
- 8 people
- Sponsor
- University of Louisville