Clinical trials: Ophthalmic Imaging
Retinal Diseases, Choroidal Diseases
Morpho-functional Evaluation of the Retina and Choroid Using Multimodal Imaging in Healthy Subjects and Patients With Retino-choroidal Diseases
The purpose of this prospective, longitudinal, single-center observational study is to identify, describe, and measure the morpho-functional characteristics and modifications of the retina and choroid using advanced multimodal…
- Conditions
- Retinal Diseases, Choroidal Diseases, Healthy Subjects
- Trial name
- RET 05-26 (NCT07615699)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Orbital Cellulitis
Fast Magnetic Resonance Imaging as Compared to Computed Tomography Scan in Pediatric Orbital Cellulitis Imaging
The aim of the study is to compare orbital and central nervous system (CNS) imaging with Computed Tomography (CT) scan to that of Fast Magnetic Resonance Imaging (Fast MRI) in children with mild, moderate or severe orbital…
- Trial name
- NCT02711436
- Testing
- Computed Tomography Scan, Fast Magnetic Resonance Imaging
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Hillel Yaffe Medical Center
Retinopathy of Prematurity
Imaging Retinal Vasculature in Infant Eyes
Retinopathy of prematurity is a leading cause of childhood blindness worldwide. The fovea, a critical location in the retina determining visual acuity and visual function, and the blood vessels around it, are abnormally developed…
- Trial name
- NCT05558059
- Testing
- Handheld Optical Coherence Tomography with OCT Angiography
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Retinal Diseases, Optic Nerve Diseases
Long-Working Distance OCT for Children
Young children age 6 month to 6 years are often not able to cooperate for advanced OCT eye imaging. The purpose of this study is to investigate the use of a novel long-working distance swept source (SS) optical coherence…
- Trial name
- LWDOCT (NCT02582164)
- Testing
- Duke Biomedical Engineering's Long-working distance OCT
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Duke University
Optic Disk Drusen
Systematic Imaging Examination in ODD
To evaluate the diagnostic value of systematic ophthalmologic imaging examination in the diagnosis of embedded optic disc drusen (ODD) in adolescents with mild visual impairment.
- Trial name
- NCT03957642
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Ocular Diseases
Ophthalmic Multimodal AI-Assisted Medical Decision-Making
This is a multi-center, retrospective clinical study designed to evaluate the application and effectiveness of an AI-assisted medical decision support system, leveraging multimodal data fusion, in ophthalmic clinical practice.
- Trial name
- NCT06755190
- Testing
- Diagnostic Test: AI-Based Diagnostic and Prognostic Model for Ocular Diseases
- Where
- 5 sites in China, Macau
- Volunteers
- 5,000,000 people
- Sponsor
- The Eye Hospital of Wenzhou Medical University
Autism Spectrum Disorders
Brain Imaging of Intranasal Oxytocin Treatment in Autism
This is a 4 part study: Phase 1a. -functional magnetic resonance imaging (fMRI) ( with oxytocin 24 IU vs. placebo = oxytocin 0 IU) - funded by grant #U54 HD079124-01, Phase 1b-eye-tracking(oxytocin 24 IU vs.
- Trial name
- NCT01945957
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of North Carolina, Chapel Hill
Healthy
Eye Movements Recording Using a Smartphone: Comparison to Standard Video-oculography and Correlation to Imaging Data in Young Athletes
This study aims to compare measurements obtained through the e-VOG application (mobile application, usable on smartphones or tablets, to record eye movements) with measurements from the standard video-oculography device…
- Trial name
- NCT05385601
- Testing
- eVOG (Mobile VideoOculoGraphy)
- Where
- Monaco
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Association de Recherche Bibliographique pour les Neurosciences
Retinal Disease, Glaucoma
Optimize Pediatric OCT Imaging
Handheld optical coherence tomography (OCT) has become an important imaging modality to evaluate the pediatric retina. The objective of this pilot study is to compare a new contact OCT system (Theia Imaging) with an…
- Conditions
- Retinal Disease, Glaucoma, Optic Nerve Diseases
- Trial name
- NCT06139523
- Testing
- Investigational contact OCT system, Investigational noncontact OCT system:
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Retinopathy of Prematurity
Feasibility of Nurse-led Retinal Imaging for Retinopathy of Prematurity Screening Employing the Optos California
Retinopathy of prematurity (ROP) is a preventable cause of blindness in babies who are born early i.e. premature. Internationally, there is a shortage of skilled ophthalmologists willing and able to screen for ROP.
- Trial name
- N_ORS (NCT06063863)
- Testing
- Nurse led screening with Optos ultra-widefield retinal-imaging device
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Nottingham
Stargardts, Retinitis Pigmentosa
High Resolution Retinal Imaging
Studying the morphology and function of the normal and diseased retina in vivo is needed for advancing the detection, diagnosis, and treatment of retinal disease.
- Conditions
- Stargardts, Retinitis Pigmentosa, Age-related Macular Degeneration, Choroideremia
- Trial name
- AOSLO (NCT01866371)
- Testing
- Retinal imaging
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cataract, Lens Disease
Magnetic Resonance Imaging to Study the Normal Eye
This study will assess the value of improved magnetic resonance imaging (MRI) techniques to study the lens of the human eye. Knowledge of how cataracts develop and progress has been hampered by the lack of human tissue available…
- Trial name
- NCT00005911
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Retinoblastoma
SPT Screening in Irradiated Hereditary Retinoblastoma Survivors
Rationale: Hereditary retinoblastoma survivors have an increased risk to develop second primary tumors (SPT) at a later age (with the highest risk in their teens), especially when they have been irradiated for retinoblastoma.
- Trial name
- NCT02329002
- Testing
- Magnetic resonance imaging
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Amsterdam UMC, location VUmc
Retinitis Pigmentosa
Retinal Imaging in Patients With Inherited Retinal Degenerations
The purpose of this study is to determine whether the structure and function of the human retina can be studied with high resolution in patients with inherited retinal degenerations using the Adaptive Optics Scanning Laser…
- Trial name
- NCT00254605
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Attentional Bias, Anxiety
Using Attention Training to Reduce Adolescents' Anxious Symptoms
During adolescence, youth undergo rapid developmental change and in some cases experience increases in worries and fearfulness, although the mechanisms that underlie this change are unclear.
- Trial name
- ABM (NCT03973580)
- Testing
- Attentional Bias Modification (ABM) task, Control task
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Mucopolysaccharidoses
New Imaging Technology to Assess Effect of Enzyme Replacment Therapy on Eye Disease Progession in Mucopolysacchardiosis
Mucopolysaccharidoses (MPS) are currently treated with Enzyme replacement therapy and Bone Marrow Transplantation (BMT). No current evidence on the effectiveness on these therapies on the eye in this systemic disease is avalible.
- Trial name
- NCT02583152
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Manchester Royal Eye Hospital
Retinoblastoma
Can Pretreatment MRI be Used to Predict Intra-arterial Chemotherapy Response in Retinoblastoma?
Retinoblastoma is the most frequent intraocular tumor in children and represents 6% of all pediatric cancers before the age of 5 years-old. The outcome is now excellent with 95 to 97% of 5-years survival rate.
- Trial name
- PREDIR (NCT03267459)
- Testing
- Dynamic contrast-enhanced MRI
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Optic Neuropathy, Optic Neuropathy, Ischemic
Building Research With Artificial Intelligence in Neuro-Ophthalmology
The research team, recognized as a world leader in Artificial Intelligence for neuro-ophthalmology, has shown that it is possible to diagnose certain neuro-ophthalmologic or neurologic disorders from a single retinal fundus image…
- Conditions
- Optic Neuropathy, Optic Neuropathy, Ischemic, Optic Neuritis, Optic Nerve Diseases
- Trial name
- BRAIN (NCT06390579)
- Testing
- Deep learning algorithm applied on retrospectively collected color fundus photographs
- Where
- France
- Volunteers
- 693 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
MGD-Meibomian Gland Dysfunction, Positron-Emission Tomography
PET-CT Imaging Features of Meibomian Glands
Analysis the results of Dry eye analysis results and PET-CT imaging comprehensively
- Conditions
- MGD-Meibomian Gland Dysfunction, Positron-Emission Tomography, Dry Eye
- Trial name
- NCT06324890
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
ASD, Functional Magnetic Resonance Imaging
MRI-Eye Tracking Pairing, a Tool for Assessing Social Cognition in Children With ASD
Most studies use static visual percepts that are less representative of joint attention versus an ecological environment. This has the consequence of decreasing the perception of an interaction with a social partner, which is an…
- Conditions
- ASD, Functional Magnetic Resonance Imaging, Eye Tracking, Social Cognition
- Trial name
- IRM-ET (NCT05194254)
- Testing
- MRI-ET
- Where
- France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens