Clinical trials: Opioid Use
Pain, Postoperative
Opioid & Steroid Use Following Tonsillectomy in Pediatric Patients
The purpose of this study is to determine if a post-operative course of oral dexamethasone affects opioid usage in pediatric patients undergoing tonsillectomy.
- Trial name
- NCT04541147
- Testing
- Dexamethasone, Analgesics
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Pain, Acute, Pain, Postoperative
Intraoperative Methadone in Children Undergoing Surgery
A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone on postoperative pain and opioid consumption in 96 children undergoing open urological surgery.
- Conditions
- Pain, Acute, Pain, Postoperative, Children, Only
- Trial name
- METACEBO (NCT04680286)
- Testing
- Methadone Hydrochloride
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Postoperative Pain, Opioid Use
Erector Spinea Plane Block in Pediatric Hip Surgery
This prospective randomized controlled double-blind study will be carried out to evaluate the effect of ultrasound-guided erector spinae plane block on the postoperative analgesia in children after hip surgeries, the total…
- Trial name
- NCT04374396
- Testing
- Real ultrasound-guided single shot erector spinae plane block (ESP B)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Cleft Palate Children
Suprazygomatic Maxillary Nerve Block in Cleft Palate Outcomes
Increased pain after cleft palate surgery is the leading cause of increased hospital length of stay, delayed oral intake, readmission, and respiratory compromise.
- Trial name
- NCT04909619
- Testing
- Ultrasound-guided bilateral suprazygomatic maxillary nerve block, Local anesthetic infiltration of the palate
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Postoperative Pain, Opioid Use
SZMN Blocks for Pain Control in Pediatric Patients Undergoing T&A
The suprazygomatic maxillary nerve (SZMN) block is a well-established, safe and effective regional technique for pain management following cleft palate procedures, however, have not been studied for patients undergoing…
- Trial name
- SZMN (NCT04797559)
- Testing
- SZMN Block
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome
Cerebral Physiology of NOWS
This study will use a new device to measure blood flow and oxygen levels in the brains of newborn infants who have had exposure to opioid medications in the womb, compared to newborns who have not had any exposure.
- Conditions
- Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome, Opioid Use Disorder, Intrauterine Exposure
- Trial name
- NIRS for NOWS (NCT07610746)
- Testing
- FD-NIRS and DCS
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent)
An Opioid Prescribing Nudge
Analyze baseline concurrent opioid prescribing metrics at the individual prescriber level in the Duke Health System on the identified three main outcome measures.
- Conditions
- Opioid Use, Unspecified, Prescription Drug Abuse (Not Dependent), Prescription Drug Abuse and Dependency, Health Behavior
- Trial name
- OHS (NCT04069403)
- Testing
- Automated Reports on prescription patterns for their patients
- Where
- United States
- Volunteers
- 427 people, healthy volunteers welcome
- Sponsor
- Duke University
Pregnancy Related, Opioid Use
Opioid Prescription After Cesarean Trial
Non-inferiority randomized trial of 5,500 women with a cesarean delivery randomized prior to discharge to either an individualized opioid prescription protocol (IOPP) that includes shared decision making or to a fixed opioid…
- Conditions
- Pregnancy Related, Opioid Use, Pain
- Trial name
- PACT (NCT04296396)
- Testing
- 0 to 20 tablets of oxycodone 5mg, Fixed opioid prescription
- Where
- 12 sites in United States
- Volunteers
- 5,521 people
- Sponsor
- The George Washington University Biostatistics Center
Opioid Use, Pain, Postoperative
ESP Block in Pediatric Patients for Postoperative Analgesia
Pediatric cardiac surgery is associated with moderate to severe postoperative pain that is related to median sternotomy. In a fast-track protocol, used in modern-day cardiac surgical care, early extubation may be facilitated by…
- Conditions
- Opioid Use, Pain, Postoperative, Quality of Life
- Trial name
- ESP1 (NCT03627897)
- Testing
- Bupivacain, saline
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cukurova University
Opioid Use Disorder, HIV Infections
Buprenorphine Integration Research and Community Health
The goal of this clinical trial is to evaluate an intervention strategy in introducing screen/evaluate/treat (SET) procedures for HIV/ hepatitis C/ and Opioid Use Disorder in Primary Care Clinics in West Virginia.
- Conditions
- Opioid Use Disorder, HIV Infections, Hepatitis C
- Trial name
- BIRCH (NCT05668780)
- Testing
- NIATx Coaching
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Opioid-use Disorder, Opioid Dependence
Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use Disorder
HOMER is a national study comparing three methods of induction for Medication Assisted Treatment (MAT) for Opioid Use Disorder (OUD); home versus office versus telehealth-based inductions.
- Trial name
- HOMER (NCT04664062)
- Testing
- Medication Assisted Treatment
- Where
- 2 sites in United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Opioid-use Disorder
Intervention to Expand Opioid Use Disorder Treatment Pharmacotherapy Prescribers
This is a cluster-randomized controlled trial designed to increase the availability of buprenorphine and extended-release naltrexone treatment capacity for opioid use disorder (OUD).
- Trial name
- NCT02926482
- Testing
- Prescriber Recruitment Bundle (PRB)
- Where
- 3 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Opioid Induced Respiratory Depression
Critical Respiratory Events in Children Requiring Naloxone: Naloxone Use as Opioid Safety Measure
Opioids are the mainstay of analgesia in hospitalized children but opioid therapy is associated with life-threatening respiratory depression requiring antagonism with naloxone.
- Trial name
- NCT01860885
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bone Fractures
Opioid Management for Discharged Emergency Department Patients
The goal of this study is to analyze the use of the Addinex system for opioid dispensing after ambulatory care to determine whether it will reduce opioid consumption, increase pill disposal, show variables that may predict opioid…
- Trial name
- NCT06592378
- Testing
- Addinex, Standard Pill Bottle
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Addinex Technologies, Inc.
Pain, Opioid Use
Inpatient Multimodal Path to RecOVEry
The goal of the proposed study is to develop and implement a comprehensive strategy to address pain management in the inpatient setting while appropriately managing pain and optimizing patient safety in the inpatient setting.
- Trial name
- IMPROVE (NCT03303664)
- Testing
- IMPROVE Protocol
- Where
- 12 sites in United States
- Sponsor
- Wake Forest University Health Sciences
Scoliosis; Juvenile, Scoliosis; Adolescence
Virtual Reality's Effect on Decreasing Pain and Subsequent Opioid Use in Pediatric Patients in the Post-Operative Period Following Scoliosis Repair
The goal of this study is to determine whether introducing VR in the immediate post-operative period following scoliosis repair can reduce perceived pain and stress in pediatric patients and in turn ultimately decrease opioid…
- Conditions
- Scoliosis; Juvenile, Scoliosis; Adolescence, Scoliosis
- Trial name
- NCT05888038
- Testing
- virtual reality
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Opioid Medication Assisted Treatment
Consortium to Disseminate and Understand Implementation of Opioid Use Disorder Treatment
Opioid use disorder (OUD) is a major cause of illness and death among Veterans for which effective treatment is a major priority of the Veterans Health Administration (VHA).
- Trial name
- CONDUIT (NCT04178551)
- Testing
- Implementation Facilitation
- Where
- 11 sites in United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Opioid Use Disorder
Medications for Opioid Use Disorders (MOUD) Via Telemedicine
Medication Assisted Treatment (MAT) of Veterans with Opioid Use Disorder (OUD) decreases mortality and improves treatment follow-up.
- Trial name
- NCT03566459
- Testing
- CBOC offering Tele-MOUD to Veterans, CBOC not offering Tele-MOUD to Veterans
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Adenotonsillectomy, Post-operative Analgesia
Non-Opioid Pain Medications After Intracapsular Adenotonsillectomy
The goal of this study is to determine if non-opioid pain control is a safe way to manage pain after intracapsular adenotonsillectomy surgery in children.
- Conditions
- Adenotonsillectomy, Post-operative Analgesia, Opioid Use
- Trial name
- NCT04791761
- Testing
- Oxycodone, Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- David Chi, MD
Adolescent Idiopathic Scoliosis
Oral Caffeine Use for Pain Management in AIS Patients After Spinal Fusion
Prospective, randomized control trial To determine if oral caffeine decreases the frequency of opioid demand in children with adolescent idiopathic scoliosis after their spinal fusion surgery To compare pain scale ratings, number…
- Trial name
- NCT04950660
- Testing
- Caffeine Tablet
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Children's Mercy Hospital Kansas City