Clinical trials: Opioid Use Disorders
Pain, Postoperative, Orthognathic Surgery
Personalization of Opioid Prescription Following Orthognathic Surgery
This study aims to investigate pain management and satisfaction following orthognathic surgery, which is a type of surgery that corrects jaw and facial bone issues.
- Conditions
- Pain, Postoperative, Orthognathic Surgery, Opioid Use, Patient Satisfaction
- Trial name
- NCT05708521
- Testing
- Personalization of dose and frequency and instituting a tapering protocol of hydromorphone post-orthognathic surgery, Standardized dose and frequency of hydromorphone with no tapering post-orthognathic surgery
- Where
- Canada
- Volunteers
- 201 people
- Sponsor
- Nova Scotia Health Authority
Pain, Pain, Acute
Assessing Opioid Care Practices Using CPV Patient Simulation Modules
This study will test the quality of opioid-related physician care decisions using a patient-simulation based measurement and feedback approach that combines multiple-choice care decisions with real-time, personalized scoring and…
- Conditions
- Pain, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04080037
- Testing
- Quality IQ Patient Simulations
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Pain Management, Opioid Use
Understanding the Postpartum Pain Experience in Women of Minority Race/Ethnicity
This study will evaluate women's experiences with pain management and perceived attitudes regarding opioid use for postpartum pain management and examine differences by race/ ethnicity.
- Conditions
- Pain Management, Opioid Use, Postpartum Health, Cesarean Delivery
- Trial name
- NCT04601246
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Northwestern University
Opioid Withdrawal (Disorder), Opioid Use Disorder
A Pharmacokinetic, Safety, and Tolerability Study of LUCEMYRA in the Treatment of Opioid Withdrawal Management in Adolescent Subjects
The goal of this clinical study is to evaluate the pharmacokinetic (PK), safety, and tolerability of LUCEMYRA in adolescents age ≥12 to <18 years old abruptly discontinuing opioid use.
- Trial name
- NCT06711640
- Testing
- LUCEMYRA (lofexidine) tablets
- Where
- United States
- Sponsor
- USWM, LLC (dba US WorldMeds)
Polysomnography, Sleep Apnea Syndromes
Adverse Long-term Consequences of Sleep Disordered Breathing: The Ottawa Hospital (TOH) Sleep Database
The primary purpose of the proposed study is to validate our previously developed predictive model for adults with obstructive sleep apnea using (i) clinical data from multiple large academic centers, (ii) a longer follow-up…
- Conditions
- Polysomnography, Sleep Apnea Syndromes, Risk Factors, Prognosis
- Trial name
- NCT03834792
- Testing
- No intervention but exposure
- Where
- Canada
- Volunteers
- 5,155 people
- Sponsor
- Ottawa Hospital Research Institute
Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome
Cerebral Physiology of NOWS
This study will use a new device to measure blood flow and oxygen levels in the brains of newborn infants who have had exposure to opioid medications in the womb, compared to newborns who have not had any exposure.
- Conditions
- Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome, Opioid Use Disorder, Intrauterine Exposure
- Trial name
- NIRS for NOWS (NCT07610746)
- Testing
- FD-NIRS and DCS
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Tonsillitis, Sleep Disordered Breathing
Opioid Use, Storage, and Disposal Among Pediatric Patients After Surgery
Opioids are an important component of post-operative pain management among children, but are often prescribed in excess and rarely disposed of appropriately.
- Conditions
- Tonsillitis, Sleep Disordered Breathing, Hernia, Hydrocele
- Trial name
- NCT03575377
- Testing
- Disposal Aid
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Nationwide Children's Hospital
Opioid Use Disorder, HIV
Expanded HIV Care in Opioid Substitution Treatment (EHOST) Trial
Opioid Substitution Treatment (OST) provides a critical opportunity for HIV testing and linkage to antiretroviral treatment. The EHOST study will evaluate a prescriber-focused intervention to increase HIV testing rates, and…
- Trial name
- EHOST (NCT02440256)
- Testing
- Expanded HIV care in Opioid Substitution Treatment
- Volunteers
- 49 people
- Sponsor
- Simon Fraser University
Opioid Withdrawal, Opioid-use Disorder
Buprenorphine in the Emergency Department
This is a pilot randomized control trial randomizing patients presenting in opioid withdrawal to the emergency department to receive either one of clonidine (usual standard of care) or buprenorphine for their opioid withdrawal.
- Trial name
- BED (NCT03174067)
- Testing
- Buprenorphine, Clonidine
- Volunteers
- 26 people
- Sponsor
- St. Joseph's Health Centre Toronto
Post-operative Pain, Opioid Use
QL vs LAI for Palatoplasty
This study will consist of patients ages 6-18 who are undergoing a surgery on the hard or soft palate of the mouth (palatoplasty), with removal of bone from the front of the hip (anterior iliac bone graft harvesting).
- Conditions
- Post-operative Pain, Opioid Use, Cleft Palate
- Trial name
- NCT06420336
- Testing
- Quadratus lumborum block, Local anesthetic infiltration
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Medical University of South Carolina
Substance-Related Disorders, Alcohol-Related Disorders
Conflict Between Maternal Autonomy and Child Health in Substance-use
Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Amphetamine-Related Disorders, Inhalant Abuse
- Trial name
- NCT02797990
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Adolescent Idiopathic Scoliosis (AIS)
Hypnosis for Pain and Nausea Reduction in Scoliosis Surgery: An Interventional Study
This study evaluates whether preoperative hypnosis can reduce postoperative pain, nausea, and opioid use in adolescents undergoing scoliosis surgery. Participants aged 12-18 years will receive hypnosis training before surgery.
- Trial name
- HYP-SCOL (NCT07854951)
- Testing
- Hypnosis
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Opioid-use Disorder
Clinical Decision Support for Opioid Use Disorders in Medical Settings: Usability Testing in an EMR
The primary objective of this pilot study is to program an opioid use disorder (OUD) clinical decision support (CDS) tool for use in an electronic medical record (EMR) and obtain high primary care physician (PCP) usability and…
- Trial name
- COMPUTE (NCT03559179)
- Testing
- Opioid Wizard
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Opioid Use Disorder, Opioid Overdose
Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUD
The goal of this multi-site observational cohort study is to link electronic health records (EHR) with novel data sources to examine insurance instability and its association with all-cause and overdose mortality in adult…
- Conditions
- Opioid Use Disorder, Opioid Overdose, Death
- Trial name
- NCT05944133
- Testing
- No intervention, observational retrospective study
- Where
- United States
- Volunteers
- 27,257 people
- Sponsor
- Kaiser Permanente
Urologic Diseases, Hypospadias
Opioid Reduction Initiative During Outpatient Pediatric Urologic Procedures Using Exparel
This study aims to evaluate the utility of long-acting liposomal bupivacaine (Exparel®) in improving pain scores and reducing narcotic pain requirements in pediatric patients following minor urologic procedures.
- Conditions
- Urologic Diseases, Hypospadias, Undescended Testes, Chordee
- Trial name
- Baby ORIOLES (NCT04826484)
- Testing
- Exparel 133 miligrams per 10 milliliter injection, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Johns Hopkins University
Musculoskeletal Injury
Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries
Musculoskeletal (MSK) injuries, including limb injuries, are the most common cause for Emergency Department (ED) visits for children with pain.
- Trial name
- No OUCH (NCT03767933)
- Testing
- Ibuprofen, Acetaminophen, Hydromorphone
- Where
- 6 sites in Canada
- Volunteers
- 710 people
- Sponsor
- University of Alberta
Pediatric ALL, Cancer
A Phase II Randomized Controlled Trial to Determine the Efficacy of an auGmented reAlity gaMe in pediatrIc caNcer Patients Who Are Opioid Naïve Undergoing Surgery to Reduce Postoperative Opioid Use (GAMING-ON Study)
To learn if playing an augmented reality game called SpellBound can reduce pain and the need for opioids in young patients scheduled for surgery.
- Trial name
- NCT05466994
- Testing
- IPAD, Augmented Reality
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Opioid Use Disorder
Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD
Despite rising rates of fatal opioid overdoses in the United States, adolescents with OUD are far less likely than adults to receive and be retained on medication for opioid use disorder (MOUD).
- Trial name
- YORS (NCT06774248)
- Testing
- Youth Opioid Recovery Support (YORS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Potomac Health Foundations
Scoliosis; Juvenile, Scoliosis; Adolescence
Virtual Reality's Effect on Decreasing Pain and Subsequent Opioid Use in Pediatric Patients in the Post-Operative Period Following Scoliosis Repair
The goal of this study is to determine whether introducing VR in the immediate post-operative period following scoliosis repair can reduce perceived pain and stress in pediatric patients and in turn ultimately decrease opioid…
- Conditions
- Scoliosis; Juvenile, Scoliosis; Adolescence, Scoliosis
- Trial name
- NCT05888038
- Testing
- virtual reality
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Opioid Use
Esophageal Dysfunction Associated With Opioids: Clinical Response and Manometric Findings After Opioid Discontinuation
Background: Opioid-induced esophageal dysfunction is characterized by altered motility of the esophageal body or impaired function of the esophageal sphincters secondary to chronic opioid use.
- Trial name
- NCT06522633
- Testing
- The intervention involves the discontinuation of the opioid.
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona