Clinical trials: Optic Disk
Diabetic Retinopathy
Effect of Laser Treatment for Diabetic Retinopathy on the Optic Disc Topography
This study analyzed diabetic patients without evidence of glaucoma who underwent panretinal photocoagulation to determine the effect on optic disc topographic parameters in non-glaucomatous patients with proliferative diabetic…
- Trial name
- NCT03476967
- Testing
- Panretinal photocoagulation
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Neuro-Ophthalmology, Optic Neuropathies
Optic Nerve Head Evaluation Through Multimodal Blood Flow Analysis: a Prospective Observational, Multi-center Study
OCT-A and eco-colordoppler are technologies which enable optic nerve head (ONH) blood perfusion detection. The aim of the study is to assess ONH vascular and structural components in optic neuropathies with and without ONH edema…
- Conditions
- Neuro-Ophthalmology, Optic Neuropathies, Optic Atrophy, Hereditary, Leber, Optic Neuropathy, Anterior Ischemic
- Trial name
- FlowONH (NCT07075887)
- Volunteers
- 70 people
- Sponsor
- Barboni
Non-Proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy New Vessels on Disc
The Effect of Combination of Vitamin A, Vitamin E, Sodium Hyaluronate 0.15% Eye Drop Compared With Sodium Hyaluronate 0.1% Eye Drop to Tear Film Stability and Conjunctival Goblet Cells Density in Patient With Non-Proliferative Diabetic Retinopathy (NPDR), and Proliferative Diabetic Retinopathy (PDR)
Commonly know that one of the complications caused by Diabetes Mellitus (DM) is microangiopathy. Microangiopathy in the long term may lead to neuropathy of the corneal nerves.
- Conditions
- Non-Proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy New Vessels on Disc, Dry Eye Syndromes
- Trial name
- NCT04000789
- Testing
- Sodium Hyaluronate, Vitamin A, Vitamin E
- Volunteers
- 96 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Myopia
Comparing Myopia Control Efficacy in Children With 4 Methods: Orthokeratology, DIMS, DISK, and SVS.
The goal of this clinical trial is to learn if 3 optical interventions（DIMS, DISC and orthokeratology) to control myopia have different efficacy to slow myopia progression in children when the control is single focus…
- Trial name
- NCT06654180
- Testing
- Orthokeratology, defocus-incorporated multiple segment lenses (DIMS) spectacles, DISK
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Kaikai QIU
Other Disorders of Optic Disc, Bilateral
Video Diversion During Fundoscopic Exam in Children
Fundoscopy is an important aspect of the neurological examination, but can be challenging in uncooperative children. This study explored whether viewing a video (selected by patient or caregiver) during eye examination improves…
- Trial name
- CAFE (NCT01673815)
- Testing
- Video (played on a computer monitor)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetic Retinopathy
Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR)
To evaluate the effect of intravitreal bevacizumab on the course of diabetic retinopathy in cases with the signs of active progressive PDR
- Trial name
- NCT00370721
- Testing
- bevacizumab
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Non-arteritic Ischemic Optic Neuropathy, Optic Disk Drusen
NA-AION Risk Factors: New Perspectives
The purpose of the study is to use new diagnostic methods (OCT and OCT-A) to shed light on risk factors for the development of NA-AION.
- Trial name
- NARROW (NCT05305079)
- Where
- 20 sites in United States, Australia and 7 more
- Volunteers
- 179 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Glaucoma, Suspect, Optic Nerve Hypoplasia and Abnormalities of the Central Nervous System
A More Engaging Visual Field Test to Increase Use and Reliability in Pediatrics
The majority of young children do not think that visual field (VF) testing of peripheral vision is similar to a game; therefore, it is not surprising that they have difficulty maintaining attention during VF testing and thus the…
- Conditions
- Glaucoma, Suspect, Optic Nerve Hypoplasia and Abnormalities of the Central Nervous System, Congenital Coloboma of the Optic Nerve, Optic Nerve Head Pits, Bilateral Congenital
- Trial name
- NCT02157025
- Testing
- Cartoon video fixation target and cartoon character voice audio instructions during Humphrey perimetry, Usual Care procedures during Humphrey perimetry for children
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Thyroid Associated Ophthalmopathy
Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid Associated Ophthalmopathy
The aim of the study is to compare the measurements of retinal nerve fiber layer (RNFL), macula and optical disc parameters obtained by optical coherence tomography (OCT), and intraocular pressure (IOP) between the patients with…
- Trial name
- NCT02766660
- Testing
- Optical Coherence Tomography
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Neon Hospital
no Obvious Abnormalities, Diabetic Retinopathy (DR)
Retinal Clinical Assessment With AI-derived Quantitative Information
This randomized controlled trial evaluates whether providing clinicians with AI-derived quantitative retinal information improves the quality and efficiency of retinal clinical assessment.
- Conditions
- no Obvious Abnormalities, Diabetic Retinopathy (DR), AMD, Cup-to-disc Ratio Bigger Than 0.5
- Trial name
- NCT07291960
- Testing
- AI-derived retinal quantitative information-assisted reporting
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Glaucoma
The High Cup/Disc Ratio in Children
To investigate of high cup/disc ratio in children.
- Trial name
- NCT00825890
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kim's Eye Hospital
Mean Blur Ratio
Isometric Exercise in NTG
Glaucoma is the second leading cause of blindness worldwide. Literature shows increasing evidence that dysfunction of ocular microcirculation in the optic nerve influences the progression of glaucoma.
- Trial name
- NCT03921372
- Testing
- Isometric exercise
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Papilledema Associated With Increased Intracranial Pressure
Ocular Point of Care Ultrasound (POCUS) to Detect Optic Disc Swelling in Comparison to Ophthalmologic Examination
Pediatric emergency department (PED) physicians frequently encounter children with symptoms that warrant evaluation of the optic disc for suspected increased intracranial pressure (ICP) such as headache, blurred vision, recurrent…
- Trial name
- NCT02992262
- Testing
- Point of care ocular ultrasound
- Volunteers
- 300 people
- Sponsor
- michal roll
Developing Novel Technique of Measuring C/D Ratio From Digital Stereo Optic Disc Images, Intraobserver Reproducibility of C/D Measurements
A New Reproducible Method of Measuring C/D Ratio of Digital Stereo Images of Optic Disc
Development of a novel computer software that will assist in measuring the cup/disc ratio in digital stereo optic disc images.
- Conditions
- Developing Novel Technique of Measuring C/D Ratio From Digital Stereo Optic Disc Images, Intraobserver Reproducibility of C/D Measurements, Interobserver Variability of C/D Measurements
- Trial name
- NCT01683942
- Volunteers
- 250 people
- Sponsor
- Meir Medical Center
Optic Disc Pit Maculopathy
Vitrectomy for Optic Disc Pit Maculopathy
The purpose of this study is to evaluate the efficacy of vitrectomy, without gas tamponade or laser photocoagulation to the margin of the optic nerve, for the treatment of macular detachment associated with optic disc pits and to…
- Trial name
- NCT01340703
- Testing
- vitrectomy without laser or gas tamponade
- Where
- Japan
- Volunteers
- 8 people
- Sponsor
- Kyorin University
Optic Disc Drusen
Spectral Domain OCT Imaging in Patients With Optic Nerve Head Drusen (Tuebingen SD-OCT IN OPTIC NERVE HEAD DRUSEN STUDY)
Optic nerve head Drusen are a mostly bilateral change of the optic nerve, eventually causing a slow, but progression loss of the visual fields.
- Trial name
- TODS (NCT02793206)
- Testing
- Imaging
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University Hospital Tuebingen
Optic Neuritis
TLR-9 Antagonism in Steroid Resistant Optic Neuritis
Although idiopathic steroid resistant optic neuritis is very uncommon, there is no established treatment protocol for such patients.
- Trial name
- NCT01424735
- Testing
- Mycobacterium w.(Mw)-freeze dried extract 0.5ml
- Where
- India
- Volunteers
- 8 people
- Sponsor
- Sudhalkar Eye Hospital
Optic Disk Drusen
Systematic Imaging Examination in ODD
To evaluate the diagnostic value of systematic ophthalmologic imaging examination in the diagnosis of embedded optic disc drusen (ODD) in adolescents with mild visual impairment.
- Trial name
- NCT03957642
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Cerebral Palsy
Optic Discs in Children With Cerebral Palsy
Hypothesis: Children born prematurely (between 8 and 9 months) with brain damage have an abnormal appearance of the optic nerve (nerve in eye) that resembles glaucoma (cupping) compared to those born before 8 months.
- Trial name
- NCT00769197
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Mississippi Medical Center
Macular Retinoschisis, Macular Detachment
Macular Retinoschisis and Detachment Associated With Glaucomatous Optic Neuropathy
Clinical features, optical coherence tomography findings and surgical outcome in eyes with macular retinoschisis and detachment with normal tension glaucoma but without optic disc pit or high myopia were evaluated.
- Conditions
- Macular Retinoschisis, Macular Detachment, Normal Tension Glaucoma
- Trial name
- NCT01862627
- Testing
- Optical coherence tomography
- Where
- Japan
- Volunteers
- 11 people
- Sponsor
- Kyorin University