Clinical trials: Optical Coherence Tomography
Disorder of Upper Digestive Tract
Near Infrared Optical Coherence Tomography of the Upper Aero-Digestive Tract
The Optical Coherence Tomography is a minimally-invasive diagnostic tool in both the office and operating room settings can identify sources of airway obstruction and effective surgical interventions.
- Trial name
- NCT00544427
- Testing
- Optical coherence tomography
- Where
- 3 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Anti-VEGF Treatment, Ranibizumab
Effectiveness of Biosimilar Ranibizumab in the Management of Diabetic Macular Edema
Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. Anti-VEGF agents are widely used to improve vision and reduce retinal swelling.
- Conditions
- Anti-VEGF Treatment, Ranibizumab, Biosimilar
- Trial name
- ERBDME (NCT07663370)
- Testing
- Ranibizumab biosimilar
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Multiple Sclerosis, Pathologic Processes
Disability, MRI Lesions and Thickness of Retinal Fibers: Evaluation 15 Years After a First Episode of Demyelination
Knowledge of the evolution of multiple sclerosis (MS) and its long-term prognostic factors is essential to guide the therapeutic management.
- Conditions
- Multiple Sclerosis, Pathologic Processes, Tomography, Optical Coherence, Magnetic Resonance Imaging
- Trial name
- DB-SEP15 (NCT03268096)
- Testing
- Cerebral MRI and Optical Coherence Tomography
- Where
- France
- Volunteers
- 182 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Choroid
Three-dimensional Choroidal Vascularity Index in Common Fundus Diseases
Explore the changes of choroidal blood perfusion in common fundus diseases by three-dimensional choroidal vascularity index, an optical coherence tomography (OCT) parameter.
- Trial name
- NCT04790084
- Testing
- no intervention
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Multiple System Atrophy, Parkinsonism
Potential Use of Autologous and Allogeneic Mesenchymal Stem Cells in Patients With Multiple System Atrophy
The prevalence of Multiple System Atrophy (MSA) is reported to be between 3.4 - 4.9 cases per 100,000 population. The estimated average incidence is 0.6 - 0.7 cases per 100,000 people per year.
- Conditions
- Multiple System Atrophy, Parkinsonism, Multiple System Atrophy, Parkinson Variant
- Trial name
- NCT04876326
- Testing
- Autologous Adipose Mesenchymal Stem Cell Implantation, Allogeneic Umbilical Cord Mesenchymal Stem Cell Implantation, Allogeneic Umbilical Cord Mesenchymal Stem Cell and Adipose Secretome Implantation
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- Universitas Indonesia
Vogt Koyanagi Harada Disease
Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease
This prospective study will include patients with Vogt-Koyanagi-Harada disease from disease onset, treated with early systemic high-dose corticosteroid and immunosuppressive therapy.
- Trial name
- NCT03399175
- Testing
- Early high-dose corticosteroid and immunosuppressive therapy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Myopia
The Immediate Effect of Defocus Spectacles On the Choroid Thickness Using Optical Coherence Tomography on Children
The purpose is to examine temporary changes in the subfoveal choroid thickness after removal and after resumed use of Defocus Incorporated Multiple Segment Spectacle Lenses (DIMS).
- Trial name
- TIDOCT (NCT06234189)
- Testing
- Defocus Incorporated Multiple Segment Spectacle Lenses (DIMS)
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Vejle Hospital
Age-related Macular Degeneration, Diabetic Retinopathy
Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging
The purpose of this study is to determine whether phase variance optical coherence tomography (PV-OCT), a software-based optical coherence tomography(OCT) image processing technology, can be used to generate angiographic images…
- Conditions
- Age-related Macular Degeneration, Diabetic Retinopathy, Hypertensive Retinopathy, Retinal Vein Occlusion
- Trial name
- PVOCT (NCT01717937)
- Testing
- Phase variance optical coherence tomography (PV-OCT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Glaucoma Secondary, Congenital Cataract
Quantitatively Analysis of Fundus Structure Characteristics in Glaucoma Following Congenital Cataract Surgery
To quantitatively analyze the fundus structure and microvascular characteristics of GFCS and non-GFCS (NGFCS) using optical coherence tomography angiography (OCTA), to explore the vascular-structural association, and to assess…
- Trial name
- NCT05446077
- Where
- China
- Volunteers
- 129 people
- Sponsor
- Sun Yat-sen University
Multiple Sclerosis, Neuromyelitis Optica
Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Oct
The purpose of this study is to determine the ability of STRATUS OCT and high resolution OCT to detect and to quantify the neural loss in multiple sclerosis and neuromyelitis optica and its subtypes.
- Trial name
- NCT01024985
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cataract
Age-Related Changes and Cycloplegia-Induced Differences in the Human Crystalline Lens
The ocular biometric parameters of the human crystalline lens including anterior chamber depth (ACD), lens thickness (LT), radii of curvature of anterior and posterior lens (ALR and PLR), lens equatorial diameter (LED), and lens…
- Trial name
- NCT04576884
- Where
- China
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Wenzhou Medical University
Keratoconus
Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking.
Aim of work: To detect abnormal corneal thinning in keratoconus using pachymetry maps measured by high-speed anterior segment optical coherence tomography (OCT).
- Trial name
- NCT03879421
- Testing
- Accelerated corneal collagen cross linking
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Reham Mahmoud Abdelrahman
Optical Coherence Tomography (OCT), Percutaneous Coronary Intervention (PCI)
OCT in Borderline Coronary Artery Lesions
To find out the safety and efficacy of Optical Coherence Tomography (OCT) in the evaluation and treatment of angiographically borderline coronary artery lesions in a Chinese population, and to compare the effectiveness of OCT…
- Conditions
- Optical Coherence Tomography (OCT), Percutaneous Coronary Intervention (PCI), Single-Photon Emission Computed Tomography (SPECT), Coronary Angiography (CAG)
- Trial name
- NCT03229993
- Testing
- OCT
- Where
- China
- Volunteers
- 220 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Age-related Cataract
Correlation Analysis of Lens Nucleus Density and Surgical Parameters Based on Ss-oct and Scheimpflug Technology
To study the correlation between three different lens nuclear opacity classification methods and intraoperative phacoemulsification parameters .
- Trial name
- NCT05028530
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Wenzhou Medical University
Healthy Skin, Nevus
The Application of Non-invasive and Cellular Level Resolution Fullfield Optical Coherence Tomography: Establishment and Analysis of Subcutaneous Cellular Level Image Database of Anatomical Locations in Healthy Volunteers and Evaluation of Usability
ApolloVue® S100 Image System is a medical device class II. The objective of this protocol is to image skin of healthy volunteers and to evaluate the performance of full-field optical coherence tomography (FF-OCT) device - the…
- Trial name
- NCT04406454
- Testing
- ApolloVue® S100 Image System
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pathological Conditions, Anatomical
The Study of Human Atherosclerosis by Polarization-Sensitive Optical Coherence Tomography
Atherosclerosis is unquestionably the leading cause of morbidity and mortality in developed countries, and the world-wide importance of acute vascular syndromes is increasing.
- Trial name
- NCT00173238
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Ischemic Heart Disease
Association Between IVUS and OCT Parameters and Invasive Physiologic Indices
1. to evaluate diagnostic accuracy and performance of IVUS and OCT-derived quantitative parameters to predict functional significance of stenosis defined using all the available physiologic indices. 2.
- Trial name
- NCT03795714
- Testing
- IVUS or OCT and Invasive physiologic indices
- Where
- 2 sites in South Korea
- Volunteers
- 166 people
- Sponsor
- Seoul National University Hospital
Macular Dystrophy
Correlation Between OCT and Mf-ERG Findings With BCVA in Patients With Macular Dystrophy
Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in patients with macular dystrophy.
- Trial name
- NCT07171541
- Testing
- OCT ,mFERG,VA test
- Volunteers
- 30 people
- Sponsor
- New Valley University
Carotid Stenosis, Optical Coherence Tomography (OCT)
Endovascular Treatment of Cerebrovascular Diseases Guided by Optical Coherence Tomography (OCT) Technology（CVD-OCT）
OCT techniques have been used in the assessment of both intracranial and extracranial lesions.(1) Preprocedural evaluation: The morphologic characteristics of carotid atherosclerotic plaques can be evaluated by OCT before surgery…
- Conditions
- Carotid Stenosis, Optical Coherence Tomography (OCT), Endovascular Treatment
- Trial name
- （CVD-OCT) (NCT06986330)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Healthy, Myopia
Ocular Imaging With Spectral Domain Optical Coherence Tomography
The purpose of this study is to analyze macular retinal thickness and macular volume using the spectral domain - optical coherence tomography (SD-OCT) in normal eyes and in eyes with various ocular diseases.
- Conditions
- Healthy, Myopia, Hypermetropia
- Trial name
- NCT00926549
- Testing
- Spectral domain-OCT (Cirrus™ HD-OCT, Carl Zeiss Meditec AG)
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yonsei University