Clinical trials: Optimization
Sequence Optimization, Protocol Optimization
Optimization of Cardiac-MR Protocols
The aim of the present study is the optimization of various magnetic resonance (MR) investigation protocols of the heart and the lung without contrast agent application as well as the generation of normal values from cardiac MR…
- Conditions
- Sequence Optimization, Protocol Optimization, Normal Values, Feasibility
- Trial name
- NCT00557869
- Where
- Austria
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Malaria, Anemia
Optimization of Seasonal Malaria Chemoprevention (SMC) Delivery
Based in part on the pivotal studies conducted in Mali, SMC was approved by WHO as a policy for malaria control in countries with seasonal malaria transmission such as Mali in March 2012.
- Trial name
- SMC (NCT02646410)
- Testing
- FPD+NDOT, FPD+DOT, DDD+NDOT
- Where
- Mali
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Bamako
Infectious Disease, COVID-19
The Study Estimates the Longitudinal Impact of a Gamified Health Education App on Students' Health and Learning Outcomes
The primary aim of this study is to assess and quantify the longitudinal impact of a mobile App-based module - FYA-003 - which is a gamified health education module for children promoting nutrition, physical activity, health…
- Conditions
- Infectious Disease, COVID-19, Physical Inactivity, Health Behavior
- Trial name
- DVx-SCHOOL (NCT05458141)
- Testing
- FYA-003
- Where
- India
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Carnegie Mellon University
Ametropia
Optimization of a Photoretinoscopy Method for Determining the Objective Refraction of Children
The objective is to compare the refractive parameters of the photorefraction prototype device without cycloplegia with the refractive parameters of reference device, an autorefractometer with and without cycloplegia.
- Trial name
- NCT06295536
- Testing
- Comparator device, Closed-field autorefractometer
- Where
- Hong Kong
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Essilor International
Lung-protective Ventilation, Respiratory Function Monitor
Optimization of Ventilation Strategies in Preterm and Term Infants in a Single-center Intervention Study
This study was a non-blinded, non-randomized intervention study in a single-center clinical setting, analyzing ventilation quality with and without RFM visibility.
- Trial name
- NCT05512689
- Testing
- Ventilations while using a respiratory function monitor
- Where
- Austria
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity
Puberty Related Intervention to Improve Metabolic Outcomes (The PRIMO Study)
Puberty represents a critical period in terms of metabolic health. Racial differences in insulin dynamics, reproductive maturation, and the associated endocrine changes may affect a female's health later in life.
- Trial name
- PRIMO (NCT01410643)
- Testing
- Macronutrient Modification
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Children With Myopia, Treatment
Clinical Study on the Effectiveness of Diverse Segments Defocus Optimization in Spectacle Lenses for Slowing Myopia Progression
Clinical Trial The goal of this clinical trial is to evaluate the effectiveness of two types of Diverse Segments Defocus Optimization (D.S.D.O.) spectacle lenses in slowing myopia progression in children.
- Conditions
- Children With Myopia, Treatment, Multizone Lens Design for Myopic Defocus, Visual Quality
- Trial name
- NCT07323251
- Testing
- Diverse Segments Defocus Optimization (D.S.D.O.) spectacle lenses
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Healthy
Potential Optimization Training in Simulation.
Simulated environment allowed safe learning of critical events and knowledge of appropriate response and treatment. Anesthesiology resident education curriculum in Lyon plans several high fidelity simulation session with a large…
- Trial name
- TOP (NCT02926599)
- Testing
- Personal Optimization Training
- Where
- France
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Claude Bernard University
Postpartum Hemorrhage
In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol
The rates of cesarean deliveries (CD) and postpartum hemorrhage (PPH) are on the rise, with failed induction and augmentation of labor as major contributing factors.
- Trial name
- NCT03434444
- Testing
- Oxytocin, Propranolol
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
HIV, Human Immunodeficiency Virus
Delivery Optimization for Pre-Exposure Prophylaxis (DO PrEP) Study
The overall goal is to determine whether an end-to-end decentralized delivery service for PrEP is more effective, safe, acceptable, and cost-effective than facility-based PrEP delivery.
- Conditions
- HIV, Human Immunodeficiency Virus, ART
- Trial name
- NCT06176859
- Testing
- HIV PrEP Delivery
- Where
- South Africa
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Lymphatic Filariasis, Soil Transmitted Helminth Infections
Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis
Approximately 3,500 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis endemic areas. The study will be performed in Indonesia in B. timori and W.
- Trial name
- DOLF-Indo (NCT01905423)
- Testing
- Albendazole (annual), Diethylcarbamazine (annual), Albendazole (semiannual)
- Where
- Indonesia
- Volunteers
- 17,108 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Adolescent - Emotional Problem, Parent-Child Relations
Family-Focused Adolescent &Amp; Lifelong Health Promotion Optimization Trial
The aim of this study is to conduct a multi-country, cluster-randomized factorial trial to optimize the Parenting for Lifelong Health (PLH) for Parents and Teens program in Moldova and North Macedonia.
- Conditions
- Adolescent - Emotional Problem, Parent-Child Relations, Family Functioning, Well-Being, Psychological
- Trial name
- FLOURISH (NCT06562244)
- Testing
- Parenting for Lifelong Health for Parents and Teens (PLH), Helping Adolescents Thrive comics, I Support My Friends
- Where
- North Macedonia
- Volunteers
- 1,316 people, healthy volunteers welcome
- Sponsor
- University of Klagenfurt
Respiratory Disease, Healthy
Optimization of Exhaled Biomarker Collection and Analysis
This is an exploratory study designed to optimize, standardize, and validate novel breath biomarkers; there are no objective endpoints.
- Trial name
- EBC (NCT05322785)
- Testing
- Breath collection
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Depression, Mental Disorder in Adolescence
The PATHway Study: Primary Care Based Depression Prevention in Adolescents
Prevention of depressive disorders has become a key priority for the NIMH, but the investigators have no widely available public health strategy to reduce morbidity and mortality.
- Trial name
- PATHway (NCT05203198)
- Testing
- Competent Adulthood Transition with Cognitive-Behavioral, Humanistic and Interpersonal Training
- Where
- 6 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Healthy
Optimisation of Monitoring for Clinical Research Studies
OPTIMON will compare the efficacy and the cost of two monitoring strategies: one based on the classic standards of quality assurance, and the other one being a priori "optimized" on the main scientific and regulatory principles.
- Trial name
- OPTIMON (NCT00780091)
- Testing
- classical monitoring strategy, optimized monitoring strategy
- Where
- France
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Feeding, Cardiovascular Diseases
Effect of Breastfeeding Optimization on Early Vascular Development
This study aims to find out whether breast feeding optimization will increase breast feeding rates and to evaluate its effect on cardiovascular risk and general health of children.
- Trial name
- BRAVO (NCT01566812)
- Testing
- Breast feeding optimization, Usual care
- Where
- Indonesia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Cardiopulmonary Resuscitation
Optimization of Quality in Cardiopulmonary Resuscitation Through Monitor-defibrillator With Feedback System
AIM: To verify the effect of a feedback system on optimizing quality during CPR on mannequins. Hypothesis: The quality of CPR performed by healthcare professionals through a defibrillator monitor with a feedback system is higher…
- Trial name
- NCT04357548
- Testing
- FEEDBACK
- Where
- Spain
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Venipuncture, Phlebotomy
Autonomous Blood Drawing Optimization and Performance Testing
The purpose of this pre-market clinical study is to evaluate the performance (efficacy) and safety of an autonomous blood drawing device (Venipuncture Device). The study consists of several phases (A, B1, B2, B3, C1, C2, C3, 0).
- Trial name
- ADOPT (NCT05878483)
- Testing
- Venipuncture Device (VD)
- Where
- 7 sites in Denmark, Netherlands
- Volunteers
- 44,658 people, healthy volunteers welcome
- Sponsor
- Vitestro B.V.
Vaccination Behavior
Child Vaccination Scheduling in China
This study aims to optimize pediatric vaccine scheduling in China . The first objective is to gather information on current vaccine schedules in China.
- Trial name
- NCT07141875
- Testing
- No intervention
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Peking University