Clinical trials: Optimization
Propionic Acidemia
Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia
This 3-part, Phase 1/2 study is designed to characterize the safety, tolerability, and pharmacological activity (as assessed by biomarker measurements) and to determine the selected dose of mRNA-3927 in participants with…
- Trial name
- NCT04159103
- Testing
- mRNA-3927
- Where
- 35 sites in United States, Canada and 6 more
- Volunteers
- 77 people
- Sponsor
- ModernaTX, Inc.
Pediatric Sever Pneumonia
A Multicenter Clinical Study on the Optimization of Timing and Efficacy Evaluation of Bronchoscopic Intervention in Pediatric Severe Pneumonia
1. Main objectives: ① To determine the optimal timing for bronchoscopic lung lavage in treating severe pneumonia in children, providing evidence-based guidance for the standardized clinical implementation of this technique.
- Trial name
- NCT07437183
- Testing
- Bronchoalveolar lavage
- Volunteers
- 3,168 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Orthodontic Bracket Placement
Optimization of Orthodontic Bracket Placement by Using Two Different Protocols of Digitally Aided Bonding
The aim of this study is to compare the accuracy of orthodontic bracket positioning using two different protocols of digitally aided bonding.
- Trial name
- NCT07503626
- Testing
- 3D printed indirect bonding trays, 3D printed guiding direct bonding trays
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Alexandria University
Primary Membranous Nephropathy
Optimization of a Decision Formula for Optimal Timing of Immunosuppressive Therapy Initiation in Primary Membranous Nephropathy: A Multicenter Retrospective Cohort Study
The goal of this observational study is to optimize the evaluation formula for the timing of initiating immunosuppressive therapy in primary membranous nephropathy in patients with primary membranous nephropathy.
- Trial name
- NCT06924476
- Where
- China
- Volunteers
- 282 people
- Sponsor
- Yipeng Liu
Cerebral Palsy
Isokinetic Strength Training in Children With Hemiparetic Cerebral Palsy
This study endeavored to assess the effect of an isokinetic strength training (IsoK-ST) program on weight-bearing symmetry, gait-symmetry, and dynamic balance in children with hemiparetic cerebral palsy (HCP).
- Trial name
- NCT04907448
- Testing
- Physical Therapy
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- Cairo University
Breast Cancer, Prostate Cancer
Improving the Quality of Radiotherapy by Multi-Institution Knowledge-Based Planning Optimization Models (Acronym: MIKAPOCo, Multi-Institutional Knowledge-based Approach in Plan Optimization for the Community)
Investigators central hypothesis is that it is possible to create libraries of "consistent" Knowledge-Based plan-models derived from large Institutional experiences.
- Trial name
- MIKAPOCo (NCT06317948)
- Testing
- treatment plan comparison
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Ospedale San Raffaele
Iron Status, Fatty Acid Status
Modification in Complementary Food Composition to Improve the Status of Iron and Fatty Acids in Infants.
The objective of this study is to determine the influence of an increase of meat in complementary food on iron status and the effect of an exchange of vegetable oil in the same food on the status of omega-3 fatty acids in infants…
- Trial name
- DINO (NCT00571948)
- Testing
- more meat and a vegetable oil rich in omega-3 fatty acids, Babyfood with usual meat content and corn oil
- Where
- Germany
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Research Institute of Child Nutrition, Dortmund
Preterm, Parent-Child Relations
Sensory Optimization of the Hospital Environment
The long-term goal of this project is to improve the health and well-being of preterm infants and their parents. Although there is evidence to support positive multisensory interventions in the NICU, these interventions are often…
- Conditions
- Preterm, Parent-Child Relations, Parents, Development, Infant
- Trial name
- SOOTHE (NCT05230199)
- Testing
- SENSE multisensory program, Monitored standard of care
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- University of Southern California
Lymphoblastic Leukemia, Acute, Childhood
Study of the Tocilizumab Optimization Timing for CART19 Associated Cytokine Release Syndrome
This is a two cohort, open-label, pilot study to describe the efficacy of administration timing of tocilizumab on CART19 (CTL019) associated cytokine release syndrome safety events in pediatric patients with CD19 expressing…
- Trial name
- NCT02906371
- Testing
- Tocilizumab, CART 19
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pennsylvania
Cardiopulmonary Resuscitation
Optimization of Quality in Cardiopulmonary Resuscitation Through Monitor-defibrillator With Feedback System
AIM: To verify the effect of a feedback system on optimizing quality during CPR on mannequins. Hypothesis: The quality of CPR performed by healthcare professionals through a defibrillator monitor with a feedback system is higher…
- Trial name
- NCT04357548
- Testing
- FEEDBACK
- Where
- Spain
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Sepsis, Device Performance
PIVO Use for Blood Cultures in the Emergency Department
The investigators will implement a protocol for use of the PIVO device for blood culture collection in the emergency department.
- Conditions
- Sepsis, Device Performance, Emergency Medicine
- Trial name
- PIVO-ED (NCT07348289)
- Testing
- PIVO device, a needle-free blood draw device
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Intermountain Health Care, Inc.
Recurrent Brain Tumors, Supratentorial PNETs
Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children
The purpose of this study is to improve overall survival while maintaining a good quality of life in pediatric patients with refractory or recurrent brain tumors (medulloblastomas, supratentorial PNETs, ependymomas WHO grade II…
- Conditions
- Recurrent Brain Tumors, Supratentorial PNETs, Medulloblastomas, Ependymomas
- Trial name
- HIT-REZ-2005 (NCT00749723)
- Testing
- carboplatin, etoposide, temozolomide
- Where
- 54 sites in Germany
- Volunteers
- 174 people
- Sponsor
- University Hospital, Bonn
Attention Deficit Hyperactivity Disorder (ADHD)
Safety and Efficacy Study of SHP465 in Children and Adolescents Aged 6-17 Years With Attention-Deficit Hyperactivity Disorder (ADHD)
The study is designed to evaluate the efficacy and safety of SHP465 in the treatment of ADHD in children and adolescents (aged 6-17 years).
- Trial name
- NCT02466425
- Testing
- SHP465
- Where
- 36 sites in United States
- Volunteers
- 264 people
- Sponsor
- Shire
Lymphoma, Lymphoblastic
German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults
This study evaluates the efficacy and tolerability of treatment for T-lymphoblastic lymphoma (T-LBL) according to a protocol for acute lymphoblastic leukemia.
- Trial name
- NCT00199017
- Testing
- Dexamethasone/Prednisolone, Cyclophosphamide, Vincristine
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Stroke
Getting on With the Rest of Your Life After a Stroke
The primary objective is to determine the extent to which participation in life's roles can be optimized through the provision of a community-based structured program providing the opportunity for physical activity, leisure, and…
- Trial name
- NCT01085240
- Testing
- Mission Possible
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- McGill University
Merkel Cell Carcinoma
SerUM Markers in MERkel Cell Carcinoma Patients: a Longitudinal moniTorIng Study for optiMization of European Guidelines
Merkel cell carcinoma (MCC) is a rare aggressive skin carcinoma. Approximately 80% of MCC are related to the Merkel Cell Polyomavirus (MCPyV). Although rates of relapse are high, the follow-up strategy lacks consensus.
- Trial name
- SUMMERTIME (NCT04705389)
- Testing
- Samples
- Where
- 10 sites in Austria, Finland and 8 more
- Volunteers
- 35 people
- Sponsor
- University Hospital, Tours
Anxiety, Depression
Factorial Optimization Trial to Test Effects of Coping Intervention Components
This study will identify components for inclusion in a coping intervention package to reduce mental health problems among children exposed to high interparental conflict after parental separation/divorce.
- Conditions
- Anxiety, Depression, Coping Skills, Emotional Problem
- Trial name
- NCT05822687
- Testing
- Education, Reappraisal Coping, Distraction Coping
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Arizona State University
Carotid Stenosis, Carotid Artery Diseases
Early Warning and Optimization Strategy in Carotid Endarterectomy
Carotid endarterectomy has been proven effective in prevention of cerebral vascular events in patients with severe carotid artery stenosis (symptomatic,>50%;asymptomatic,60%).
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Stroke, Vascular Diseases
- Trial name
- NCT01210937
- Testing
- CEA and TCD monitoring
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Attention Deficit Hyperactivity Disorder
A Study of TAK-503 in Children and Teenagers With Attention Deficit Hyperactivity Disorder (ADHD)
The main aim of this study is learn more about long-term TAK-503 treatment in children and teenagers with ADHD for whom earlier stimulant treatment did not work. The study has two parts (A and B).
- Trial name
- NCT04085172
- Testing
- Guanfacine hydrochloride (TAK-503), Atomoxetine hydrochloride
- Where
- 50 sites in United States, Austria and 7 more
- Volunteers
- 396 people
- Sponsor
- Shire
Acute Malnutrition in Infancy, Acute Malnutrition in Childhood
Optimization of the Simplified Protocol in Mali: a Cluster Randomised Pragmatic Trial
Acute malnutrition is a condition that affects more than 45 million children under the age of five at any time and requires specific treatment to ensure patient survival.
- Conditions
- Acute Malnutrition in Infancy, Acute Malnutrition in Childhood, Acute Malnutrition, Severe
- Trial name
- NCT06594341
- Testing
- Visit frequency, Suppression of the transition period, Simplified treatment
- Where
- Mali
- Volunteers
- 6,249 people
- Sponsor
- International Rescue Committee