Clinical trials: Optimization
Surgery, Aging
Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments
The researchers will conduct observations, interviews, and focus groups with clinicians, staff and patients of the Perioperative Optimization of Senior Health (POSH) clinic, which conducts preoperative comprehensive geriatric…
- Conditions
- Surgery, Aging, Health Care Utilization, Frailty
- Trial name
- NCT06184919
- Testing
- Process Mapping: Observations, Process Mapping: Interviews, Process Mapping: Focus Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Wisconsin, Madison
Pain, Postoperative, Orthognathic Surgery
Personalization of Opioid Prescription Following Orthognathic Surgery
This study aims to investigate pain management and satisfaction following orthognathic surgery, which is a type of surgery that corrects jaw and facial bone issues.
- Conditions
- Pain, Postoperative, Orthognathic Surgery, Opioid Use, Patient Satisfaction
- Trial name
- NCT05708521
- Testing
- Personalization of dose and frequency and instituting a tapering protocol of hydromorphone post-orthognathic surgery, Standardized dose and frequency of hydromorphone with no tapering post-orthognathic surgery
- Where
- Canada
- Volunteers
- 201 people
- Sponsor
- Nova Scotia Health Authority
Junctional Epidermolysis Bullosa
Optimizing IV Gentamicin in JEB
Herlitz junctional epidermolysis bullosa (H-JEB), an incurable and fatal inherited skin disease, is caused by loss-of-function mutations in LAMA3, LAMB3 and LAMC2.
- Trial name
- NCT04140786
- Testing
- Gentamicin Sulfate, Injectable
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Southern California
Ametropia
Optimization of a Photoretinoscopy Method for Determining the Objective Refraction of Children
The objective is to compare the refractive parameters of the photorefraction prototype device without cycloplegia with the refractive parameters of reference device, an autorefractometer with and without cycloplegia.
- Trial name
- NCT06295536
- Testing
- Comparator device, Closed-field autorefractometer
- Where
- Hong Kong
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Essilor International
Acne, Acne Vulgaris
Clinical Workflow Optimization Using Artificial Intelligence for Dermatological Conditions
Artificial intelligence (AI) based on imaging holds tremendous potential to enhance visual diagnostic accuracy in the medical field.
- Conditions
- Acne, Acne Vulgaris, Alopecia, Androgenetic, Pigmented Lesions
- Trial name
- IDEI_2023 (NCT06263413)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- AI Labs Group S.L
Surgical Residency, Workplace Culture
The Surgical Education Culture Optimization Through Targeted Interventions Based on National Comparative Data - "The SECOND Trial"
Due to a number of factors, residents are susceptible to mistreatment (i.e., discrimination, harassment, and abuse) and toxic outcomes (i.e., burnout, attrition, and suicidality).
- Conditions
- Surgical Residency, Workplace Culture, Mistreatment, Burnout
- Trial name
- SECOND (NCT03739723)
- Testing
- Resource allocation to improve surgical learning environments
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- Indiana University
Respiratory Disease, Healthy
Optimization of Exhaled Biomarker Collection and Analysis
This is an exploratory study designed to optimize, standardize, and validate novel breath biomarkers; there are no objective endpoints.
- Trial name
- EBC (NCT05322785)
- Testing
- Breath collection
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Indiana University
Crohn Disease
Therapeutic Optimization Study Based on MR Enterocolonography in Patients With Crohn's Disease
This randomized, controlled study aims to evaluate the impact of therapeutic intervention (step up) for the patients who are clinical remission with Magnetic Resonance Enterocolonography (MREC) active.
- Trial name
- NCT02332356
- Testing
- azathioprine or adalimumab and infliximab
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Tokyo Medical and Dental University
Chronic Hepatitis B
The Study on Clinical Outcome and Treatment Optimization of Chronic Hepatitis B Patients With Hypoviremia
Chronic hepatitis B seriously endangers the health of our people, especially the occurrence of HCC, which brings huge economic burden and life threat to our people. 84% - 92% of HCC in China is related to chronic HBV infection.
- Trial name
- NCT05357183
- Testing
- PEG-IFN
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Beijing Ditan Hospital
Physician Workflow, Resource Utilization
Evaluating a Our Practice Advisory (OPA) to Optimize Hemoglobin A1c (A1c) and Thyroid-Stimulating Hormone (TSH) Test Orders
Our Practice Advisory (OPA) are essential tools in clinical decision-making. The alerts are designed to guide providers towards evidence-based practices and improve patient outcomes.
- Trial name
- NCT06993805
- Testing
- OPA
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- University of California, Los Angeles
Kawasaki Disease, Pilot Study
Model-informed Dose Optimization for Rivaroxaban in Children With Giant Coronary Artery Aneurysm After Kawasaki Disease
Based on a population pharmacokinetic model-based dose optimization study, a 15 mg-equivalent, age-, and bodyweight-adjusted dosing regimen for Chinese children with giant coronary artery aneurysms after Kawasaki disease was…
- Conditions
- Kawasaki Disease, Pilot Study, Coronary Artery Aneurysm, Rivaroxaban
- Trial name
- NCT06978439
- Testing
- Rivaroxaban (Xarelto)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Fudan University
Heart Failure, Cardiac Resynchronization Therapy
Tissue Doppler Imaging (TDI) Versus Electrocardiography (ECG) Interventricular Pacing Delay Optimization in Cardiac Resynchronization Therapy (CRT)
The aim of this study was to compare the response to cardiac resynchronization therapy when the interventricular pacing interval was optimized by Tissue Doppler Imaging (TDI) to response when it was optimized following QRS width…
- Trial name
- NCT01179997
- Testing
- Interventricular pacing delay optimization by using Tissue Doppler-derived displacement curves, Electrocardiographic optimization of the interventricular pacing delay according to QRS width
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Hospital Clinic of Barcelona
Aortic Stenosis, Trans-catheter Aortic Valve Implantation
Optimization of Commissural Alignment During Transcatheter Aortic Valve Implantation With Evolut FX+
Purpose of the Study The purpose of this study is to investigate how a transcatheter aortic valve (TAVI, biological valve prosthesis) can best be positioned in order to avoid blockage of the coronary arteries by the valve…
- Conditions
- Aortic Stenosis, Trans-catheter Aortic Valve Implantation, Commissural Alignment
- Trial name
- ALIGN-EFX (NCT07217691)
- Testing
- Implantation of Evolut FX pluss TAVI device from Medtronic in LAO 25, Implantation of Evolut FX pluss TAVI device from Medtronic in patient specific degree.
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Giant Cell Arteritis
Giant Cell Arteritis - Optimization of Diagnostics
Giant cell arteritis - Optimization of diagnostics
- Trial name
- GAME (NCT05248906)
- Testing
- Giant cell arteritis
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Atopic Dermatitis
Optimization of Atopic Dermatitis Treatment That Requires Second-line Systemic Therapy Through Predictive Models
This is a low-intervention phase IV trial. The main objective is to optimize the treatment of patients with moderate-severe atopic dermatitis that require systemic treatment after failure, intolerance or contraindication to…
- Trial name
- NCT06366932
- Testing
- Second-line systemic treatment, Folllow-up of second-line systemic treatment already started
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Duodenum Disease
Duodenal tIssue ResEction aCquisiTion (DIRECT) Study
To evaluate the quality of cold snare resection specimens of duodenal mucosa tissue in patients undergoing an upper gastrointestinal interventional endoscopy in order to improve the processing of histological samples and its…
- Trial name
- DIRECT (NCT06333093)
- Testing
- Cold snare
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Be a Member of the French Judo Federation
Optimization of Exercise Capacity in Elite Judokas: Effects of a High-intensity Hypoxic Training Program With Eccentric Overload and Effect of Gender.
The main objective of this study is to evaluate the effects of an innovative training program on key factors affecting judo performance.
- Trial name
- HYPOXPERF JUDO (NCT07778017)
- Testing
- Hypoxia training, Eccentric cycling
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Down Syndrome, Aneuploidy
Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies
To collect samples for the purpose of developing and optimizing an in vitro noninvasive prenatal diagnostic (NIPD) test. The NIPD test employs circulating cell free (ccff) DNA extracted from whole blood samples collected from…
- Trial name
- CHARMM-AP (NCT01052688)
- Testing
- Maternal blood draw of 30 to 50ml
- Where
- 10 sites in United States
- Volunteers
- 150 people
- Sponsor
- Sequenom, Inc.
Vaccination Behavior
Child Vaccination Scheduling in China
This study aims to optimize pediatric vaccine scheduling in China . The first objective is to gather information on current vaccine schedules in China.
- Trial name
- NCT07141875
- Testing
- No intervention
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Peking University
Attention Deficit Hyperactivity Disorder (ADHD)
Dose-Optimization Study Evaluating the Efficacy, Safety and Tolerability of Vyvanse (Lisdexamfetamine Dimesylate) in Children Aged 6-12 Diagnosed With ADHD
Assess the efficacy \& tolerability of Vyvanse when children aged 6-12 years diagnosed with ADHD are dosed to optimal effect.
- Trial name
- NCT00500071
- Testing
- Vyvanse (lisdexamfetamine dimesylate)
- Where
- 46 sites in United States
- Volunteers
- 318 people
- Sponsor
- Shire