Clinical trials: Oral Aphthous Ulcers
HIV Infections, Stomatitis, Aphthous
Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection
PRIMARY: To evaluate the effectiveness and safety of thalidomide for treatment of oral and esophageal aphthous ulcers (those unrelated to a known infection or malignancy) in patients with advanced HIV disease.
- Trial name
- NCT00000790
- Testing
- Thalidomide
- Where
- 40 sites in United States, Puerto Rico
- Volunteers
- 164 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome
Thalidomide to Treat Oral Lesions in HIV-Infected Patients
This study will test the effectiveness of topical thalidomide in healing mouth sores in HIV infected patients. Oral (PO) thalidomide heals these sores at a dose of 200 mg per day.
- Conditions
- Acquired Immunodeficiency Syndrome, Burning Mouth Syndrome, HIV Infection
- Trial name
- NCT00001524
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis Syndrome
Efficacy and Safety of Thalidomide for Pediatric PFAPA Syndrome
The goal of this clinical trial is to evaluate the efficacy and safety of thalidomide in the treatment of children with Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis (PFAPA) syndrome.
- Trial name
- NCT07476625
- Testing
- Thalidomide (50mg), Colchicine
- Volunteers
- 106 people
- Sponsor
- Wenjie Zheng
Minor Recurrent Aphthous Stomatitis Lesions
The Effect of 2-DeNT Oral Topical Powder on Minor Recurrent Aphthous Ulcer
This is a prospective, randomized, blinded, placebo-controlled, crossover clinical trial to evaluate the efficacy of 2-DeNT oral topical powder in the treatment of recurrent aphthous stomatitis (RAS).
- Trial name
- NCT02142543
- Testing
- 2-DeNT powder
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Recurrent Mouth Ulcers
Omega-3 and Quality of Life in Recurrent Aphthous Stomatitis Patients
The study aims at evaluating the effect of omega-3 on patients suffering recurrent oral aphthous ulcers
- Trial name
- NCT01831453
- Testing
- omega-3
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- October 6 University
Aphthous Stomatitis
Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis
The intention of the study is to study the effects of Ibuprofen, Diphenhydramine and Aluminium MgS in decreasing the signs of recurrent aphthous stomatitis (RAS)
- Trial name
- NCT01293968
- Testing
- Ibuprofen, Diphenhydramine and Aluminium MgS, Diphenhydramine and Aluminium MgS
- Where
- 2 sites in Iran
- Volunteers
- 37 people
- Sponsor
- Qazvin University Of Medical Sciences
Behcet's Syndrome
Colchicine Randomized Double-Blind Controlled Crossover Study in Behcet's Disease
Colchicine was first used in Behcet's Disease (BD), in 1977. There are controversial reports of the efficacy of Colchicine in BD.
- Trial name
- NCT00700297
- Testing
- Colchicine
- Where
- Iran
- Volunteers
- 169 people
- Sponsor
- Tehran University of Medical Sciences
Recurrent Aphthous Ulcer, Recurrent Aphthous Stomatitis
Curcumin and Nanocurcumin in Oral Aphthous Ulcer
Recurrent aphthous ulcer is a painful inflammatory lesion with a high prevalence. Since the etiology is not clear, several strategies have been proposed to reduce pain and severity of its symptoms.
- Trial name
- NCT04385979
- Testing
- Gel
- Where
- Iran
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Sore Throat, Aphthous Ulcer
Observational Study of OROSEDAL in Sore Throat and Minor Oral Lesions
This prospective, multicenter, national, observational, non-interventional post-market clinical follow-up study will evaluate the performance and safety of OROSEDAL in children and adults with sore throat or minor oral lesions…
- Conditions
- Sore Throat, Aphthous Ulcer, Oral Lichen Planus, Minor Mouth Lesion
- Trial name
- NCT07620353
- Testing
- OROSEDAL
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Laboratoires Elerte
Oral Aphthous Ulcer
Clinical Evaluation of Topical Coenzyme Q10 in Management of Oral Aphthous Ulcer
Recurrent oral aphthous ulcer is the most common oral lesion in occurrence and one of cause is oxidative stress so investigators need to use antioxidant drugs like topical coenzyme Q10 gel to treat the lesion and more safe for…
- Trial name
- NCT03213769
- Testing
- topical coenzyme Q10 gel, Carpabol gel
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodic Fever, Aphthous Stomatitis
Probiotics and Corticosteroids for Treating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA)
The purpose of study is to see if adding probiotics to corticosteroid treatment for children with PFAPA could improve the health and daily of patients through reduction in febrile period frequency and length, along with…
- Conditions
- Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis
- Trial name
- PFAPA (NCT02535962)
- Testing
- Lactobacillus acidophilus and Bifidobacterium lactis
- Sponsor
- Connecticut Children's Medical Center
Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease
Natural History of Trisomy 8-Associated Autoinflammatory Disease (TRIAD) and Related Disorders
Background: Trisomy 8 mosaicism is a genetic disorder that can increase inflammation in the body. Symptoms include fevers; sores or ulcers in the mouth, digestive tract, or genital area; skin rashes; problems in organs or…
- Conditions
- Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease, Mucosal Ulcerations
- Trial name
- NCT07683104
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Recurrent Aphthous Stomatitis
Clinical Evaluation of Fluid Extract of Chamomilla Tincture for Oral Aphthae
Recurrent aphthous stomatitis is a difficult to treat and quite common chronic inflammatory disease of the oral mucosa. This study evaluates the fluid extract from Chamomilla recutita's safety and effectiveness in treatment of…
- Trial name
- NCT01122147
- Testing
- chamomilla tincture mouthwash
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Mashhad University of Medical Sciences
Aphthus Ulcer
Oxygenated Gel Therapy in the Management of Oral Aphthous Ulcers
Interventions of both groups: Oxygenated gel Group: 15 patients who used oxygenated gel (Blue®m, Wijhe, Netherlands) were trained by the co-investigator (A.H) through real demonstration for topical application of the gel on…
- Trial name
- NCT06910579
- Testing
- topical application of oxygenated gel, topical application of Triamcinolone acetonide gel
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- British University In Egypt
Oral Mucositis, ORAS
Combination of Diclofenac Potassium and Propolis in the Therapy of Oral Aphthosis
The combination of diclofenac and propolis could enhance the healing of recurrent aphthous ulcers, instantly relieve symptoms, improve the quality of life, and present a de novo and cost-effective regime help in oral ulcer…
- Conditions
- Oral Mucositis, ORAS, Oral Infection, Oral Ulcer
- Trial name
- NCT05413096
- Testing
- Combination of diclofenac potassium and propolis
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Recurrent Aphthous Stomatitis
Effect of Zinc Oxide Ointment on Recurrent Aphthous Stomatitis
This randomized placebo-controlled trial evaluated the effectiveness of zinc oxide ointment in the treatment of recurrent aphthous stomatitis (RAS).
- Trial name
- ZO-RAS (NCT07565181)
- Testing
- zinc oxide, Placabo
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Faculty of Dental Medicine for Girls
Aphthous Stomatitis, Burning Mouth Syndrome
Evaluation and Treatment of Oral Soft Tissue Diseases
This study offers evaluation and treatment of patients with diseases of the mouth or systemic diseases that involve the mouth. The protocol is not designed to test new treatments; rather, patients will receive current standard of…
- Conditions
- Aphthous Stomatitis, Burning Mouth Syndrome, Lichen Planus, Mouth Disease
- Trial name
- NCT00001601
- Testing
- Electrocardiogram, Biopsies, Diagnostic imaging
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Aphthous Stomatitis
Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study
Recurrent aphthous stomatitis (RAS) is one of the most common of oral mucosa diseases that affects approximately 20% of the general population.
- Trial name
- NCT01210014
- Testing
- zinc sulphate 220mg/day in one dosage
- Where
- Iran
- Volunteers
- 14 people
- Sponsor
- Qazvin University Of Medical Sciences
Oral Aphthae
Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae
The purpose of this study is to determine whether low doses of prednisolone, or colchicine are effective in the treatment of oral aphthae.
- Trial name
- NCT00723268
- Testing
- Prednisolone, Colchicine
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea
Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders
Background: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever syndrome of childhood.
- Conditions
- Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa), Obstructive Sleep Apnea, Tonsillitis, Tonsil Disorder
- Trial name
- NCT05656365
- Where
- 3 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)