Clinical trials: Oral Cavity Disease
Gingivitis
The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With Gingivitis
This study aims to determine the levels of NLRP3, caspase-1 and IL-1β concentrations in the gingival crevicular fluid of paediatric patients with gingivitis and their changes after periodontal treatment.
- Trial name
- NCT06507280
- Testing
- Periodontal theraphy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Carious Lesion, Ready-made Crowns
The Relation Between Oral Hygiene and Microbial Load in the Oral Cavity After Restoring Primary Molars With Two Types of Ready-made Crowns
Following the restoration of primary molars with stainless steel and bioflex crowns, an evaluation of the current state of oral hygiene in relation to the amount of microorganisms and gingival health in the oral cavity will be…
- Trial name
- bioflex crown (NCT06767670)
- Testing
- stainless steel crown, bioflex crown
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Iron Deficiency Anemia
Prevalence of Oral Manifestations of Iron Deficiency Anemia in a Sample of Egyptian Population
According to WHO Reportin 2002, iron deficiency anemia was considered to be the most important contributing factor to the global burden of anemia.
- Trial name
- NCT03365570
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Cairo University
Denture Stomatitis
Effects of Denture-Related Stomatitis on Blood Pressure in Denture Wearers
The aim of this study is to evaluate the influence of presence of oral fungal infection, which leads to denture-related stomatitis, on blood pressure, endothelial function and immune cell phenotype in patients wearing dentures.
- Trial name
- NCT02166450
- Testing
- Nystatin
- Where
- 2 sites in Poland
- Volunteers
- 80 people
- Sponsor
- Jagiellonian University
Systemic Lupus, Sjogren's Syndrome
Evaluation of Influenza A/H3N2 Vaccine in Patients With Rheumatologic Diseases
Studies in the literature have shown reduced effectiveness of influenza A (H3N2) virus vaccine (20-40%) when compared to A (H1N1) and influenza B.
- Trial name
- NCT03540823
- Testing
- Inactivated and fragmented influenza vaccine (A / Michigan / 45/2015 (H1N1) pdm09-like virus, A / Singapore / INFIMH-16-0019 / 2016 (H3N2) -like virus; B / Phuket / 3073/2013-like virus)
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Cleft Lip, Congenital Nose Malformation
Fabrication of Sequential Naso-Alveolar Molding Appliances in the Treatment of Cleft Lip/Nose Deformities
There is a robust body of research suggesting that the use of pre-surgical orthopedic devices prior to definitive cleft lip/nose repair results in significant improvement of facial aesthetics with long term follow up.
- Conditions
- Cleft Lip, Congenital Nose Malformation, Deformity, Nose Deformities, Acquired
- Trial name
- NCT04334590
- Testing
- Cleft Lip/Nose Repair without PSIO, Presurgical Infant Orthopedic Therapy
- Where
- United States
- Sponsor
- Johns Hopkins University
Lymphoma
Etoposide in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of etoposide in treating patients with relapsed…
- Trial name
- NCT00002880
- Testing
- Etoposide phosphate
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Hand, Foot, and Mouth Disease (HFMD), Enterovirus 71 Infection
Bridging Clinical Trial of EV71 Vaccine in Vietnamese Children
The purpose of this study is to evaluate the immunogenicity and safety of an inactivated Enterovirus Type 71 (EV71) vaccine, manufactured by Sinovac, in healthy Vietnamese children aged 6 to 71 months.
- Trial name
- NCT07793175
- Testing
- EV71 vaccine
- Where
- Vietnam
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Handfoot-mouth Disease
Effect of Xiaoer Jiebiao Oral Liquid on Hand-foot-mouth Disease
This is a single-blinded randomized trial aiming to evaluate the effectiveness of Xiaoer Jiebiao Oral liquid in combination with Ribavirin treatment on patients with hand-foot-mouth disease compared with the controlgroup that…
- Trial name
- NCT02328651
- Testing
- Ribavirin plus Xiao'er jiebiao oral liquid, Ribavirin
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Children's Hospital of Fudan University
Oral Mucositis
Feasibility Study of a Protocol to Treat Pediatric Oral Mucositis by Low-level Laser Therapy
Low Level Laser Therapy has been used for a few years in some pediatric hospital centers for chemo- and radiotherapy-induced oral mucositis care. It may promote ulceration's healing, limits mucositis severity and associated pain.
- Trial name
- PEDIALASE (NCT02604329)
- Testing
- "Oncolase Digi" therapy laser diode
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Toulouse
Oral Cancer, Oral Squamous Cell Carcinoma
Salivary Expression of SOX7 in Oral Squamous Cell Carcinoma: Diagnostic Accuracy Study
The study will include patients with oral cancer and healthy controls of both sexes. Subjects having any systemic diseases or other types of cancer will be excluded.
- Trial name
- NCT06031337
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Graft Versus Host Disease
Compassionate Use of Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Gastrointestinal Tract
RATIONALE: Beclomethasone may be effective in treating patients who have graft-versus-host disease of the gastrointestinal tract.
- Trial name
- NCT00055666
- Testing
- beclomethasone dipropionate
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Roswell Park Cancer Institute
Juvenile Idiopathic Arthritis, Gingivitis
Clinical and Biochemical Evaluation of Dental and Periodontal Conditions in Children With Juvenile Idiopathic Arthritis
Aimed to be done in the planned thesis to evaluate the dental and periodontal health of patients with newly diagnosed JIA and healthy-periodontal problems with cytokines from saliva and oxidative stress markers non-invasively…
- Conditions
- Juvenile Idiopathic Arthritis, Gingivitis, Decay, Dental
- Trial name
- NCT05217277
- Testing
- Humans ELISA kits
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Marmara University
Cleft Lip and Palate
Evaluation of Efficiency the Full Digital Nasoalveolar Molding (F-D-NAM) on Nose and Lip Esthetics and Maxillary Arch Changes in Infants With Cleft Lip and Palate
Objectives: The aim of this study is to validate the measurements produced from a new 3D analysis using facial scans in infants with unilateral cleft lip and palate.
- Trial name
- NCT07660042
- Testing
- F-D-NAM
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
Candidiasis, Esophageal, HIV Infections
Evaluation of Amphotericin B in the Treatment of Biopsy Proven Candida Esophagitis in Immunocompromised Patients
To determine the appropriate duration of amphotericin B therapy for Candida esophagitis. To compare the effectiveness of two different amphotericin B doses in the treatment of biopsy-proven Candida esophagitis.
- Trial name
- NCT00002041
- Testing
- Amphotericin B
- Where
- United States
- Sponsor
- Bristol-Myers Squibb
Complicated Urinary Tract Infection, Infection
Single Dose Intravenous Antibiotics for Complicated Urinary Tract Infections in Children
Urinary tract infections (UTI) are commonly encountered in children, with 7% diagnosed with at least one UTI by the age of 19 years.
- Conditions
- Complicated Urinary Tract Infection, Infection, Pediatric Infectious Disease
- Trial name
- CHOICE UTI (NCT04876131)
- Testing
- Benzylpenicillin - single dose, Benzylpenicillin - three days, Gentamicin - single dose
- Where
- 7 sites in Australia, New Zealand
- Volunteers
- 396 people
- Sponsor
- Murdoch Childrens Research Institute
Pediatric Kidney Disease
Shockwave Lithotripsy (SWL) Versus SWL and Oral Dissolution Therapy (ODT) For Paediatrics Radiolucent Renal Stone
To conduct a RCT comparing SWL versus combined ODT and SWL as non-invasive methods for management of paediatrics radiolucent renal stone.
- Trial name
- NCT05896345
- Testing
- SWL, SWL and ODT
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Mansoura University
Dental Plaque and Gingivitis, Oral Hygiene Reinforcement During Fixed Orthodontic Treatment
Mobile Application Push Notification in Improving Oral Hygiene Behaviour in Adolescent Orthodontic Patients
This research looks at whether using a mobile phone app that sends push-notification reminders can help adolescent orthodontic patients keep their teeth and gums cleaner during treatment.
- Trial name
- IMGS_EZGIGI (NCT07288853)
- Testing
- Ezgigi with push notification, EzGigi
- Where
- Malaysia
- Volunteers
- 78 people
- Sponsor
- Kumeran A/L Mohan
Periodontitis
Periodontitis Stage III and IV and Oral Health Related Quality of Life
Patients diagnosed with stage III or IV periodontitis during routine visits at the department of periodontology will undergo a validated questionnaire to understand the impact of the disease on their quality of life.
- Trial name
- NCT05481567
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Cagliari
Dental Plaque
Plaque Removal Efficacy of a U-Shaped Sonic Power Toothbrush in Children
The objective of this single-use, examiner blinded, randomized, two-period, cross-over, IRB-approved clinical study is to evaluate the safety and plaque removal efficacy of AutoBrush®, a new children's 360° sonic toothbrush…
- Trial name
- NCT06300073
- Testing
- Experimental: U-shaped Power Toothbrush
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Lander Enterprises, LLC
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