Clinical trials: Osteopathia
Adverse Bone Health, HIV Infection
Calcium and High-dose Vitamin D Supplementation on Bone Mineral Density Among HIV-infected Children and Adolescents
Since there is no cure for HIV, therefore antiretroviral therapy must be taken life-long. Some of the HIV medications can negatively impact the health of the bone and is even more exacerbated in perinatally HIV-injected children…
- Trial name
- CAL-D (NCT02426840)
- Testing
- High dose vitamin D and calcium, Normal dose vitamin D and calcium
- Where
- 5 sites in Thailand
- Volunteers
- 200 people
- Sponsor
- Chiang Mai University
Short Stature, Constitutional Delay of Growth and Development
Role of Nutrition and Hormones in Boys With Disordered Growth
This study will determine whether adding more calories to the diet helps boys with growth problems grow better while being treated with Nutropin, a growth hormone that is used to help children grow taller.
- Conditions
- Short Stature, Constitutional Delay of Growth and Development, Dwarfism, Pituitary
- Trial name
- NCT00102258
- Testing
- Growth Hormone Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Spinal Neoplasms
Evaluation of Effectiveness of CyberKnife Stereotactic Radiosurgery for Spinal Tumors
This study aims to explore the reliability of the combination of functional magnetic resonance imaging and radiomics for evaluation of the therapeutic efficacy of CyberKnife stereotactic radiosurgery for spinal tumors.
- Trial name
- NCT04192383
- Testing
- Cyberknife stereotactic radiosurgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Neoplasms of Bone and Articular Cartilage With Unspecified Anatomical Site
EVERolimus and LenvAtinib Versus Everolimus for Bone Sarcoma
Those studies demonstrate strong rationale to combine a multikinase inhibitor targeting VEGFR, PDGFR with mTOR inhibitor. Moreover, another multi-targeted TKI, lenvatinib monotherapy showed promising activity in osteosarcoma.
- Trial name
- NCT07619950
- Testing
- Everolimus and Lenvatinib, Everolimus
- Volunteers
- 94 people
- Sponsor
- Yonsei University
Pectus Carinatum, Quality of Life
Validity and Reliability of the Turkish Version of the Pectus Carinatum Body Image Quality of Life Questionnaire for Patients With Pectus Carinatum
In children with severe pectus carinatum, a significant loss of self-esteem, impairment in social behavior due to a decrease in quality of life associated with physical appearance and mental health has been reported.
- Conditions
- Pectus Carinatum, Quality of Life, Body Image, Brace
- Trial name
- NCT04782362
- Testing
- Brace Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Acibadem University
Bone Neoplasms
Using Mesenchymal Stem Cells to Fill Bone Void Defects in Patients With Benign Bone Lesions
The purpose of this study is to determine whether using mesenchymal stem cells will heal benign bone lesion defects faster than demineralized bone matrix
- Trial name
- NCT00851162
- Testing
- Trinity multipotent stem cells, Demineralized bone matrix(DBM)
- Where
- United States
- Sponsor
- Emory University
Osteoporosis
Osteoporosis Treatment Protocol in Patients With Fragility Fractures: Application and Efficacy
Osteoporosis and osteoporotic fractures, especially hip fractures, have a significant impact on public healthcare. Despite the fact that the patients that have suffered an osteoporotic fracture have 86% increased risk of…
- Trial name
- NCT04861142
- Testing
- Anti-osteoporotic medication( alendronate or denosumab)
- Where
- Greece
- Volunteers
- 350 people
- Sponsor
- University General Hospital of Heraklion
Hypothermia Following Anesthesia, Neurosurgery
Preventing Inadvertent Hypothermia in Patients Undergoing Major Spinal Surgery
Background Major spinal surgery tend to be lengthy with an increased risk of hypothermia. A quality improvement project of patients undergoing major spinal surgery showed that 67 % were hypothermic at the beginning of surgery.
- Conditions
- Hypothermia Following Anesthesia, Neurosurgery, Scoliosis, Kyphosis
- Trial name
- NCT03193905
- Testing
- Bairhugger Full Access Underbody Blanket, Cotton blanket - control group
- Volunteers
- 60 people
- Sponsor
- Aalborg University Hospital
Growth Hormone Deficiency, Short Stature
Biological Age in Children With GH Deficiency Undergoing Hormone Replacement Therapy
The primary objective of the study is to evaluate the epigenetic age in children with GH deficiency, before and after 6 months of treatment with growth hormone replacement therapy.
- Trial name
- ETABIOGHD (NCT06294860)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Istituto Auxologico Italiano
Stenosis, Histiocytoma
Genetic Study of Patients and Families With Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma of the Bone
OBJECTIVES: I. Identify and characterize the gene causing diaphyseal medullary stenosis with malignant fibrous histiocytoma of the bone. II. Determine the clinical manifestations of this disease in these patients.
- Trial name
- NCT00007046
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Exercise-related Amenorrhea
Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
One aim of this study is to determine changes in body composition and hormones that differentiate athletes who stop getting their periods versus those who continue to get their periods and non-athletes.
- Trial name
- NCT00946192
- Testing
- Transdermal 17Beta-estradiol, progesterone, Ethinyl Estradiol + Desogestrel
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Systemic Lupus Erythematosus, Sjögren's Disease
Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers
This study is designed to provide treatment with deucravacitinib for participants with SLE/SjD (Systemic Lupus Erythematosus/Sjögren's Disease) and pediatric participants with PsO/PsA (Psoriasis/Psoriatic Arthritis) who have…
- Conditions
- Systemic Lupus Erythematosus, Sjögren's Disease, Psoriasis, Psoriatic Arthritis
- Trial name
- NCT07791199
- Testing
- Deucravacitinib
- Volunteers
- 2,300 people
- Sponsor
- Bristol-Myers Squibb
Scoliosis, Regional Anesthesia
Erector Spine Plane (ESP) Block for Analgesia in Pediatric Scoliosis Surgery
Postoperative pain after scoliosis correction surgery is severe and usually requires long-term intravenous opioid therapy. Local anesthetic options are limited and include intrathecal opioids and epidural analgesia.
- Conditions
- Scoliosis, Regional Anesthesia, Pediatric Anesthesia, Orthopedic Disorder of Spine
- Trial name
- NCT05944393
- Testing
- Ropivacaine 0.2% Injectable Solution, Normal saline 0.9% Injectable Solution
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Poznan University of Medical Sciences
Pectus Excavatum
Field-test and Psychometric Validation of the Pectus Excavatum Evaluation Questionnaire in the Dutch Pectus Excavatum Population
A questionnaire that can measure disease severity from the patients perspective in patients with pectus excavatum already exists in English (Pectus Excavatum Evaluation Questionnaire; PEEQ).
- Trial name
- TRANSLATE (NCT06918392)
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Erik de Loos
Recurrent Cutaneous Melanoma, Recurrent Lip and Oral Cavity Carcinoma
Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors
This phase I trial studies the side effects and best dose of cord blood-derived expanded allogeneic natural killer cells (donor natural killer [NK] cells) and how well they work when given together with cyclophosphamide and…
- Conditions
- Recurrent Cutaneous Melanoma, Recurrent Lip and Oral Cavity Carcinoma, Recurrent Malignant Endocrine Neoplasm, Recurrent Malignant Female Reproductive System Neoplasm
- Trial name
- NCT03420963
- Testing
- Cord Blood-derived Expanded Allogeneic Natural Killer Cells, Cyclophosphamide, Etoposide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Osteogenesis Imperfecta
Study of Osteogenesis Imperfecta Tendon
Osteogenesis imperfecta (OI) is a rare genetic disease due to a mutation in one of the genes encoding either type I collagen or a protein involved in its synthesis. This leads to bone fragility with fractures and deformities.
- Trial name
- SOIT (NCT06065111)
- Testing
- study tendon damage in osteogenesis imperfecta patients
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Université Catholique de Louvain
Orbital Bone Fracture, Maxillary Cyst
Application of CAD-CAM Technology in Orbital Bone Reconstruction
Reconstruction of orbital defects resulting after trauma; tumor resection; maxillary cyst; craniofacial anomalies and sequestrated bone….
- Conditions
- Orbital Bone Fracture, Maxillary Cyst, Maxillary Neoplasms, Zygomatic Fractures
- Trial name
- CAD-CAM (NCT05438784)
- Testing
- orbital bone reconstruction with patient specific titanium implant, orbital bone reconstruction with preformed titanium plate preoperatively bended on stereolithographic model
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Hatem Adel Aboelhassan
Craniosynostosis
Comparing MRI to CT on Pediatric Craniosynostosis.
The purpose of this study is to develop and test the effectiveness and diagnostic quality of Zero Echo Time Magnetic Resonance Imaging (ZTE MRI) in comparison to CT.
- Trial name
- NCT04704284
- Testing
- Zero Echo Time Magnetic Resonance Imaging (ZTE MRI)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Failed Back Surgery Syndrome, Spinal Stenosis
Value of Three-dimensional Rotational Epidurography on Percutaneous Epidural Adhesiolysis
Conventional epidurography (CE) is thought to have insufficient usefulness on percutaneous epidural adhesiolysis (PEA). The investigators aimed to evaluate the association between the outcome of PEA and three…
- Trial name
- NCT04216992
- Testing
- Cone beam computed tomography
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Growth Hormone Deficiency
Phase 2 Study of LUM-201 in Children With Growth Hormone Deficiency (OraGrowtH210 Trial)
This is a multi-national trial. The goals of the trial are to study LUM-201 as a possible treatment for Pediatric Growth Hormone Deficiency (PGHD) and investigate a predictive enrichment marker (PEM) strategy to select subjects…
- Trial name
- OraGrowtH210 (NCT04614337)
- Testing
- LUM-201, rhGH Norditropin® pen (34 µg/kg)
- Where
- 43 sites in United States, Australia and 4 more
- Volunteers
- 104 people
- Sponsor
- Lumos Pharma
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