Clinical trials: Overdose, Drug
Infection, Vitamin A Overdose
Vitamin A Total Body Stores of Senegalese Children in Relation to Their Infectious Status
Despite economic growth in developing countries, Sub-Saharan Africa still faces food insecurity malnutrition and infections. Micronutrient deficiency and infectious diseases still remain a public health problem and have a…
- Trial name
- NCT03207308
- Testing
- Vitamin A supplementation
- Where
- Senegal
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Cheikh Anta Diop University, Senegal
Bronchopulmonary Dysplasia, Vitamin D Overdose
25OH Vitamin D Overdoses and Risk of Bronchopulmonary Dysplasia or Death
Several studies have demonstrated that vitamin D deficiency at birth is a risk factor of bronchopulmonary dysplasia. However, in an animal model of bronchopulmonary dysplasia vitamin D overdose has also been associated with an…
- Trial name
- 25OHVDORBPDD (NCT05944055)
- Testing
- Is 25 OH vitamin D overdose a risk factor of bronchopulmonary dysplasia or death ?
- Where
- France
- Volunteers
- 173 people
- Sponsor
- Hospices Civils de Lyon
Sodium Picosulfate Overdose, Magnesium Sulfate Overdose
Picoprep Split-dose Before Colonoscopy in Children
Before having a colonoscopy, it is necessary to clean the intestine well in order to have a complete view of the intestinal mucosa.
- Conditions
- Sodium Picosulfate Overdose, Magnesium Sulfate Overdose, Children, Only, Bowel Disease
- Trial name
- NCT04767633
- Testing
- split dose vs standard dose of sodium pico sulfate plus magnesium sulfate in children for bowel cleansing
- Volunteers
- 590 people
- Sponsor
- Azienda Ospedaliera "Sant'Andrea"
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Opioid-use Disorder, Opioid Dependence
Young Houston Emergency Opioid Engagement System
The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opioid Overdose, Opioid Use
- Trial name
- YHEROES (NCT04811014)
- Testing
- Buprenorphine, Naloxone Drug Combination, Individual Counseling, Peer Recovery Support Services
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anxiety, Midazolam Overdose
Effect of Aromatherapy on Perioperative Anxiety Level in Cesarean Sections
Spinal anesthesia has been accepted as the first choice for elective cesarean section due to its easy application technique and elimination of the risks of difficult intubation and aspiration.
- Conditions
- Anxiety, Midazolam Overdose, Breast Feeding
- Trial name
- NCT05334537
- Testing
- Aromatherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
HIV, Hepatitis C
Ending Transmission of HIV, HCV, and STDs and Overdose in Rural Communities of People Who Inject Drugs (ETHIC)
This study will evaluate the referral to harm reduction services (HRS) including syringe services, naloxone overdose prevention, substance use treatment referral, HIV, HCV, and STD testing and referral and linkage to care through…
- Conditions
- HIV, Hepatitis C, Opioid-use Disorder, Injection Drug Use
- Trial name
- ETHIC (NCT04427202)
- Testing
- Referral to harm reduction services
- Where
- 2 sites in United States
- Volunteers
- 306 people
- Sponsor
- University of Chicago
Overdose
SOONER Feasibility Study Protocol
Opioid Overdose Education and Naloxone Distribution programs (OEND) involve training and equipping people who are likely to be bystanders to opioid overdose to recognize and respond to opioid-related emergencies by activating…
- Trial name
- SOONER (NCT03821649)
- Testing
- SOONER Training and Naloxone Kit Kit, Community or Hospital-Based Training
- Where
- 4 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Paracetamol Overdose
The Markers and Paracetamol Poisoning Study 2
Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission.
- Trial name
- MAPP2 (NCT03497104)
- Testing
- Surplus blood tests
- Where
- United Kingdom
- Volunteers
- 464 people
- Sponsor
- NHS Lothian
Vitamin D Deficiency, Osteopenia
Monitored vs Standard Supplementation of Vitamin D in Preterm Infants
The purpose of this study is to determine wheather the monitored vitamin D (vit D) therapy is safer and more effective than standard therapy in pretrem infants.
- Conditions
- Vitamin D Deficiency, Osteopenia, Nephrolithiasis, Drug Overdose
- Trial name
- MOSVID (NCT03087149)
- Testing
- monitored vit D supplementation, standard vit D supplementation
- Where
- Poland
- Volunteers
- 109 people
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Substance-Related Disorders
Benzodiazepines in Opiate Replacement Therapy
Drug-related deaths (DRD) are a significant and increasing public health problem in Scotland. Benzodiazepines and BZD-type substances (BZD) are increasingly implicated in DRD.
- Trial name
- BENZORT (NCT04622995)
- Testing
- Benzodiazepine
- Where
- United Kingdom
- Volunteers
- 46,899 people, healthy volunteers welcome
- Sponsor
- University of Stirling
Opioid-Related Disorders, Drug Overdose
Prescribe to Save Lives
The U.S. is in the midst of an epidemic of opioid overdose deaths. The common use of opioids among persons living with HIV, along with their common use of benzodiazepines, has resulted in high rates of opioid overdose among this…
- Trial name
- PTSL (NCT03175640)
- Testing
- Implementation intervention
- Where
- 2 sites in United States
- Volunteers
- 294 people
- Sponsor
- Baystate Medical Center
Baseline Epidemiologic Assessment
Baseline Epidemiologic Assessment of Abuse-Deterrence of MorphaBond Extended Release (BEAD-MB)
The main objectives of this study are to provide surveillance/descriptive data to (a) assess utilization of MorphaBond ER and selected comparators overall and by age group and census regions using nationally-projected quarterly…
- Trial name
- BEAD-MB (NCT04033094)
- Testing
- MorphaBond ER, Comparator Drug
- Where
- United States
- Volunteers
- 17,566 people
- Sponsor
- Daiichi Sankyo
Overdose, Adverse Event
Consequences of Doing What Should Not be Done in Primary Care
Retrospective observational study in a random selection of 5% of digital records active between 2014 and 2017 to quantify the frequency of Do not do primary care recommendations, calculating the over-cost related to them and…
- Trial name
- SOBRINA (NCT03482232)
- Testing
- Benzodiazepines, Non-steroidal anti-inflammatory drugs, paracetamol
- Where
- 2 sites in Spain
- Volunteers
- 750,000 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Drug Overdose
Nasal Naloxone for Narcotic Overdose
The goal of this study is to determine if nasal naloxone is inferior to standard care for naloxone administration in a pre-hospital setting.
- Trial name
- NCT01912573
- Testing
- Intranasal (IN) naloxone, Intravenous (IV) naloxone, Intramuscular (IM) naloxone
- Where
- 3 sites in United States
- Volunteers
- 236 people
- Sponsor
- Judith Feinberg
Acetaminophen Overdose
Safety and Efficacy Study of a New Formulation of Acetylcysteine Injection
The primary purpose of this study is determine if a new formulation of Acetadote is at least as effective as the current formulation in the prevention and treatment of acetaminophen overdose related liver injury.
- Trial name
- NCT01118663
- Testing
- Acetadote EF (Ethylenediaminetetraacetic Acid (EDTA) - Free), Acetadote
- Where
- 14 sites in United States
- Volunteers
- 17 people
- Sponsor
- Cumberland Pharmaceuticals
Medication Abuse, Harm Reduction
Clinical Decision Support to Improve System Naloxone Co-prescribing
The objective of this study is to evaluate the impact of a clinical decision support (CDS) alert to facilitate the co-prescribing of naloxone, an opioid overdose reversal agent, with high-risk opioid prescriptions.
- Conditions
- Medication Abuse, Harm Reduction, Opioid Overdose, Opioid Prescribing
- Trial name
- NCT06271668
- Testing
- Naloxone Co-prescribing Clinical Decision Support (CDS)
- Where
- United States
- Volunteers
- 114,272 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Drug Use
Geographical Information System (GIS) Mapping to Assess the Need for IEP Provision in Tayside
The aim of this study is to review the current provision of IEP services provided across Tayside and consider to what extent they are contributing to keeping this vulnerable population safe.
- Trial name
- NCT04099719
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- NHS Tayside
Opioid Use, Post-thoracotomy Pain Syndrome
Serratus Anterior Plane Block for Management of Post Thoracotomy Pain
This is a single-center, randomized, prospective study evaluating the effect of serratus anterior plane block performed after induction of anesthesia, but before the start of surgery on postoperative opioid requirements.
- Conditions
- Opioid Use, Post-thoracotomy Pain Syndrome, Local Anaesthetic Agent Overdose, Local Anesthetic Complication
- Trial name
- SAPB (NCT04258436)
- Testing
- Serratus anterior block
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Indiana University
Harm Reduction, Naloxone
Vending Machine Naloxone Distribution for Your Community (VENDY)
Vending machines are an innovative strategy shown to increase access to naloxone, a medication used to reverse opioid overdose. The aim of this proposal is to study the reach of a community-initiated, stakeholder engaged…
- Conditions
- Harm Reduction, Naloxone, Opioid Overdose
- Trial name
- NCT06429436
- Testing
- VENDY
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- University of Colorado, Denver