Clinical trials: Oxidative Stress
Peripheral Arterial Disease
Mechanisms That Produce the Leg Dysfunction of Claudication & Treatment Strategies
Intermittent claudication afflicts 5% of the US population older than 55 years of age and develops along with hardening of the arteries of the legs.
- Trial name
- NCT01970332
- Testing
- Revascularization Surgery, Supervised exercise therapy
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Nebraska
Thalassemia Major
The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major
The effect of N-acetylcysteine as antioxidant and its effect on pretransfusion hemoglobin and iron overload in patients with thalassemia were compared to patients who didn't receive n-acetylcysteine after 3 months of study…
- Trial name
- NCT04260516
- Testing
- N-acetyl cysteine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Child, Only, Essential Hypertension
Juvenile Essential Arterial Hypertension and Vascular Function
The main goal of this study is to investigate the association of the juvenile essential arterial hypertension with systemic micro- and macrovascular reactivity and cerebral vascular function, and to examine the potential impact…
- Trial name
- NCT05109013
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Oxidative Stress, Inflammation
Effect of Mother DHA Supplementation on Term Newborn.
In the present study, we evaluate the effect of the mother suplementación with DHA during the gestation and lactation on diverse aspects of the development of newborn.
- Conditions
- Oxidative Stress, Inflammation, Infant Development
- Trial name
- NCT01947426
- Testing
- DHA Supplementation, Control (milk without DHA)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Cystic Fibrosis
Effects of an Antioxidant-Enriched Multivitamin Supplement on Inflammation and Oxidative Stress in Cystic Fibrosis
The purpose of this study will be to evaluate the effects of a modified formulation of AquADEKs (AquADEKs-2) on markers of inflammation, antioxidant levels and oxidative stress.
- Trial name
- AquADEKs-2 (NCT01859390)
- Testing
- AquADEKs-2, control multivitamin
- Where
- 15 sites in United States
- Volunteers
- 73 people
- Sponsor
- University of Colorado, Denver
Cerebral Arterial Aneurysm
Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function
The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the intracranial aneurysm surgery about antioxidant effect.
- Trial name
- NCT02691416
- Testing
- propofol postconditioning, sevoflurane
- Volunteers
- 60 people
- Sponsor
- The Third Central Clinical College of Tianjin Medical University
Non-alcoholic Fatty Liver Disease
Fructose and Liver Diseases in Youth: Help Them FLY
Obesity has been increasing all over the world. This has lead to a significant increase of a liver disease in children called non-alcoholic fatty liver disease (NAFLD).
- Trial name
- FLY (NCT05528471)
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Oxidative Stress
Normal Values of Oxidative Stress, Taurine, and Related Markers
The role of oxidative stress in disease pathology is increasingly recognized. At present, the development of biomarkers of this state is in its infancy and the availability of clinically validated assays is lacking.
- Trial name
- NCT02649777
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Autistic Disorder
Treating Oxidative Stress in Children With Autism
An open label trial was undertaken in 40 autistic children to determine whether treatment with metabolic precursors methylcobalamin and folinic acid would improve plasma biomarkers of oxidative stress and measures of core…
- Trial name
- NCT00692315
- Testing
- Methylcobalamin (methylB12)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Oxidant Imbalance, Pulmonary Function
In Utero Household Air Pollution Exposure and Lung Development in Ghana
Household air pollution from cook stoves using solid fuels dominates total population air pollution exposures. Females and young children are disproportionately affected as they either perform or are present for the majority of…
- Trial name
- NCT02200289
- Where
- Ghana
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Oxidative Stress
Oxidative Stress in OR Personnel
The purpose of this study is investigate to the effect(s) of chronic occupational exposure to N20 and volatile anesthetics on the extent of oxidative stress (DNA damage and the generation of the biochemical markers) in operating…
- Trial name
- NCT02654834
- Testing
- Exposure to nitrous oxide or other volatile anesthetics
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Postural Tachycardia Syndrome
Local Vasoconstriction in Postural Tachycardia Syndrome
The investigators study will determine how often blood flow regulation abnormalities and abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and oxidative stress occur in POTS and the mechanism(s) of…
- Trial name
- NCT01210430
- Testing
- Losartan, Ascorbic Acid (Vitamin C), Normal Saline
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Obesity, Nonalcoholic Fatty Liver Disease
Fatty Liver Disease in Obese Children
Although weight reduction through physical activity-based interventions is the mainstay therapy for nonalcoholic fatty liver disease (NAFLD), its maintenance is difficult and typically unsuccessful.
- Conditions
- Obesity, Nonalcoholic Fatty Liver Disease, Cardiovascular Disease
- Trial name
- NCT02117700
- Testing
- N-acetyl cysteine 600 mg once/day, N-acetyl cysteine 600mg twice/day
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Nemours Children's Clinic
Asthma, Wheezing
Evaluation of Toxic Metals, Trace Elements and Total Antioxidant Activity in Children With Recurrent Wheezing
The purpose of this study is to evaluate hair trace elements and toxic metals and plasma total antioxidant activity in children with recurrent wheezing and to evaluate whether these toxic metals and trace elements have any impact…
- Trial name
- NCT00749528
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Kecioren Education and Training Hospital
Iron Deficiencies, Inflammation
Effect of Supplementation With Anthocyanins on Iron Metabolism in Female Swimmers
The study included 8-weeks supplementation of black chokeberry extract with 18% standardization of the anthocyanins content (dose 2×200 mg per day), or a placebo product that was made from chokeberry fiber.
- Conditions
- Iron Deficiencies, Inflammation, Oxidative Stress, Female Athlete Triad
- Trial name
- NCT06486623
- Testing
- Black chokeberry extract in capsules with 18% standardization of the anthocyanins content, Chokeberry fiber in capsules
- Where
- Poland
- Volunteers
- 22 people
- Sponsor
- Poznan University of Physical Education
Passive Smoking, Oxidative Stress
Salivary TAS, TOS, LL-37 and Dental Status in Passive Smoking Children
The aim of the present study was to determine the effect of passive smoking on the levels of salivary TAS, TOS, LL-37 and dental status in children.In the study the parents of children were asked to fill out a complete survey…
- Conditions
- Passive Smoking, Oxidative Stress, Dental Caries, Children
- Trial name
- NCT04292548
- Testing
- taking saliva samples to determine TAS, TOS and LL-37
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Merve Erkmen Almaz
Narghile
Oxidative DNA Damage Enhancement by Vitamin C Among Narghile Smokers and Non-smokers
This study aims to evaluate oxidative DNA damage among hookah smokers compared to non-smokers by measuring biomarkers of oxidative stress in blood samples.
- Trial name
- DNA Damage (NCT07141823)
- Testing
- Vitamin C (Ascorbic Acid) regularly has been taken
- Where
- Iraq
- Volunteers
- 96 people
- Sponsor
- Nora Tariq Mohammed
Obstructive Sleep Apnea of Child
Endothelial Dysfunction and Oxidative Stress in Children With Sleep Disordered Breathing.
Sleep disordered breathing (SDB) is a common disease in both adults and children and is caused by the obstruction of the upper airway during sleep.
- Trial name
- NCT02247167
- Testing
- adenotonsillectomy
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Roma La Sapienza
Cardiovascular Diseases, Heart Diseases
Epidemiology: Oxidative Stress and Early Atherosclerosis
To measure serum concentrations of alpha tocopherol, selenium and all major carotenoids (alpha- and beta- carotene, lutein, (beta-cryptoxanthin and lycopene) in Black and white, male and female, high and low education individuals…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Arteriosclerosis
- Trial name
- NCT00005393
- Volunteers
- 5,115 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Sickle Cell Disease
Endothelial Monocyte-activating Polypeptide-II in Egyptian Sickle Patients
This study objectives to assess the role of endothelial monocyte-activating polypeptide II (EMAP II) as a marker of endothelial dysfunction and disturbed angiogenesis in sickle cell disease and to identify its correlation With…
- Trial name
- NCT03903133
- Testing
- Vitamin E
- Volunteers
- 50 people
- Sponsor
- Ain Shams University