Clinical trials: Oxygen Inhalation Therapy
Chronic Wounds, Obliterating Arteriopathy of the Lower Limbs
Clinical Evaluation of an Innovative Non-contact Optical Device for Skin Oxygenation Imaging
According to international consensus, information on the level of skin oxygenation is necessary for the diagnostic management of chronic wounds.
- Trial name
- IMOXY (NCT05187676)
- Testing
- Oxygen saturation measurement using the IPAM device, Transcutaneous oxygen partial pressure (TcPO2) using the PeriFlux6000 device
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France
Stroke, TIA
A New Oxygen Mask for Carotid Endarterectomy Under Local Anaesthesia
The purpose of this study is to determine the effectiveness of oxygenation and patient-acceptability of a novel oxygen face mask in patients undergoing carotid endarterectomies (CEAs).
- Conditions
- Stroke, TIA, Surgery, Anaesthesia
- Trial name
- NCT01064908
- Testing
- OxyMask
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Apnea, Hypoxia
Effects of Automated Adjustment of Inspired Oxygen With Combined Adaptive Mechanical Backup Ventilation as Compared to Automated Oxygen Adjustment Alone in Preterm Infants With Intermittent Hypoxemic Events During Non-invasive Ventilatory Support
In this 2-phase cross-over study the investigators test the hypothesis that automated adjustment of the inspired oxygen with the combined use of synchronized noninvasive SpO2-sensitive and apnea-sensitive backup-ventilation…
- Trial name
- NCT02774408
- Testing
- Saturation sensitive backup ventilation
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Respiratory Failure
Regional Distribution Differences Between Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation
Neurally adjusted ventilatory assist (NAVA) is an FDA approved mode of mechanical ventilation. This mode of ventilation is currently in routine use in adult, pediatric and neonatal intensive care units.
- Trial name
- NCT01504373
- Testing
- Neurally Adjusted Ventilatory Assist (NAVA)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Children's Hospital
Preterm Infant, RDS
Effects of Automated Adjustment of FiO2 on Cerebral and Arterial Oxygenation in Preterm Infants
In this study the investigators test the hypothesis that automated FiO2 adjustment increases the time of brain tissue oxygenation within the intended reference range.
- Trial name
- FiO2-Contr (NCT01942473)
- Testing
- Automated FiO2 Control
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- University of Ulm
Hypoxic-Ischemic Encephalopathy
A Study of a Blood Marker in Newborns With Brain Injury Caused by Lack of Oxygen at Birth
Perinatal asphyxia is a significant health problem with an incidence of 1 to 8 per 1,000 live births and can lead to serious morbidity and mortality during the neonatal period.
- Trial name
- NCT07292220
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mustafa Gürkan
Laryngeal Papilloma, Recurrent
Optiflow vs. Convential Anesthesia During Pediatric Laryngeal Papilloma Removal
This is a randomized cross over study of high flow oxygen delivery via nasal cannula vs. conventional tubeless anesthesia for patients undergoing dubulking surgery for laryngeal papilloma.
- Trial name
- NCT05215249
- Testing
- Transnasal humidified high-flow oxygen delivery
- Sponsor
- Massachusetts Eye and Ear Infirmary
Infant Respiratory Distress Syndrome, Ventilator Lung; Newborn
Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants
Two-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (Continous positive airway pressure (CPAP) or…
- Trial name
- CLAC-4 (NCT03163108)
- Testing
- Closed-loop automatic oxygen control (CLAC) fast in addition to RMC, Closed-loop automatic oxygen control (CLAC) slow in addition to RMC
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Tuebingen
Infant, Premature
Automated Oxygen Control in Preterms on Non-invasive Ventilation
This randomised controlled trial aims to investigate the effectiveness of closed-loop automated oxygen control (CLAC) in preterm infants receiving non-invasive respiratory support and determine if it reduces the duration of…
- Conditions
- Infant, Premature, Airway Morbidity
- Trial name
- NCT07622563
- Testing
- Closed loop automated oxygen control
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- King's College Hospital NHS Trust
Pneumonia
Oxygen Therapy for Children With Moderate Hypoxemia in Malawi
The goal of this pilot clinical trial is to compare standard of care, low-flow oxygen, and high-flow nasal canula oxygen in pediatric patients aged 1-59 months with pneumonia and an oxygen saturation of 90-93% in Malawi.
- Trial name
- NoGoLo2 (NCT06176664)
- Testing
- Low flow oxygen, High-flow nasal cannula oxygen
- Where
- Malawi
- Volunteers
- 21 people
- Sponsor
- Johns Hopkins University
Anemia of Prematurity, Necrotizing Enterocolitis
Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency encountered in the newborn intensive care unit and represents a significant cause of morbidity and mortality in infants born prematurely.
- Trial name
- NCT01735578
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Utah
Heart Transplantation, Exercise Capacity
Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients
The purpose of this study is to investigate the effect of physical training on work capacity and vascular function after heart transplantation, cardiac transplant recipients are randomized to 8 weeks of intense physical training…
- Conditions
- Heart Transplantation, Exercise Capacity, Endothelial Function
- Trial name
- NCT01028599
- Testing
- Intensive physical exercise
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Respiratory Insufficiency, Hypoxia
Effects of High Flow Nasal Cannula on Deadspace Reduction and Regional Distribution of Ventilation
1. To determine the lowest nasal cannula flow rate in which upper airway deadspace is reduced. Hypothesis - The lowest flow rate of high flow nasal cannula (HFNC) will reduce upper airway (extrathoracic) deadspace and improve…
- Trial name
- HFNC (NCT02460653)
- Testing
- HFNC Flow Rate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Pulmonary Disease, Chronic Obstructive
Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in COPD Patients
Respiration failure type 2 is loss of the lungs ability to take up oxygen (O2) and get rid of carbon dioxide (CO2). The diagnosis is based on blood gas measurement of pressures of O2 and CO2.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxemia
- Trial name
- NCT00888342
- Testing
- supplementary oxygen, zopiclone, alcohol
- Where
- 2 sites in Norway
- Volunteers
- 150 people
- Sponsor
- LHL Helse
Asphyxia
Resuscitation of Late-preterm Infants by Using Room Air or 100% Oxygen
In this randomized control trial, the investigators hypothesize that late-preterm infants resuscitated with a "low oxygen delivery" strategy (initiation of resuscitation with room air) will result in a significant reduction in…
- Trial name
- NCT01305031
- Testing
- Resuscitation, 100% oxygen
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Nanjing Medical University
Angina
Effect of Oxygen During Percutaneous Coronary Intervention for Pain Relief
Nasal oxygen is widely used as pain relief against ischemic pain during Percutaneous Coronary Intervention (PCI). However, to our knowledge no randomised clinical trials have tested this.
- Trial name
- OXYPAIN (NCT01413841)
- Testing
- Nasal oxygen, Regular nasal air
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Intrauterine Growth Retardation (IUGR), Lung Function Tests
Early Lung Function Trajectories: Comparison Between Infants With and Without Intrauterine Growth Restriction.
During intrauterine life, some babies are smaller or grow less than expected. This fetal growth abnormality, called fetal growth restriction (FGR), can be diagnosed by ultrasound.
- Conditions
- Intrauterine Growth Retardation (IUGR), Lung Function Tests, Preterm Infant, Respiratory Monitoring
- Trial name
- ELFIGO (NCT06919757)
- Testing
- fetal ultrasound to assess lungs, heart and diaphragm
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Hyperoxia, Hypoxia
Computer-assisted Oxygen Therapy Weaning in Critically Ill Children
The study is designed to evaluate the feasibility, safety and clinical utility of using an adaptive model to wean oxygen by computer assistance.
- Trial name
- NCT03550469
- Testing
- Computer-assisted Oxygen Weaning
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Stanford University