Clinical trials: Oxygenation
Cerebral Hypoxia
Brain Oxygenation-II
The Brain Oxygenation-II study (BOx-II) is a phase-II, multicenter, single-arm clinical trial evaluating interventions based on near-infrared spectroscopy (NIRS) monitoring of cerebral oxygen saturation in extremely premature…
- Trial name
- BOx-II (NCT05171881)
- Testing
- Intervention for cerebral hypoxia
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Valerie Chock, M.D., M.S. Epi
Cystic Fibrosis (CF)
Machine Learning Prediction of Pulmonary Function in Children With Cystic Fibrosis
Cystic fibrosis is a multisystem genetic disorder characterized by progressive pulmonary impairment and extrapulmonary limitations.
- Trial name
- NCT07770854
- Testing
- Archived Multidimensional Clinical and Functional Assessment Data
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Gazi University
Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication
ECMO ABI Detection With Hyperfine
The primary objective is to characterize the prevalence and type of ABI following cannulation for pediatric patients who require ECMO support.
- Conditions
- Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication, Hypoxia-Ischemia, Brain, Stroke, Acute
- Trial name
- NCT06469801
- Testing
- Hyperfine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Congenital Disorders, Cerebral Desaturation
International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery
The goal of this observational study is to determine the incidence of perioperative cerebral desaturation in neonates undergoing surgery for congenital malformations. The main questions it aims to answer are: 1.
- Conditions
- Congenital Disorders, Cerebral Desaturation, Neonatal Surgery
- Trial name
- NCT05673499
- Testing
- NIRS/EEG monitoring
- Where
- 15 sites in United States, Australia and 5 more
- Volunteers
- 900 people
- Sponsor
- Children's Hospital of Philadelphia
Preterm Birth, Oxygen Toxicity
Fetal Haemoglobin and Cerebral and Peripheral Oxygenation.
The aim of this study is to investigate the relationship between cerebral and peripheral oxygenation and oxygen extraction, as measured by NIRS (near-infrared spectroscopy ), and the FHbF (fraction of fetal hemoglobin) and…
- Conditions
- Preterm Birth, Oxygen Toxicity, Fetal Hemoglobin
- Trial name
- HbFIN (NCT04802629)
- Testing
- Near-infrared spectroscopy
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Respiratory Disease, Respiratory Distress Syndrome
Oxygenation Efficacy of "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
Based on early bench-testing data and subsequent clinical case studies in the U.S., "Intrinseque Health" non-rebreathing mask (IHNRM) has delivered virtual elimination of air entrainment and preferential delivery of all available…
- Conditions
- Respiratory Disease, Respiratory Distress Syndrome, Respiratory Failure
- Trial name
- NCT06310629
- Testing
- High Flow Nasal Cannula, "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital
Necrotizing Enterocolitis
Early Predictors of Necrotizing Enterocolitis in Neonates
The goal of this project is to identify neonates who are predisposed to Necrotizing Enterocolitis (NEC). the investigators will determine the effectiveness of non-invasive measures as well as biochemical markers to identify…
- Trial name
- NCT03210831
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Bronchopulmonary Dysplasia
Fluid Filled Lung Oxygenation Assistance Trial
The primary study objective is to assess the safety and feasibility of perfluorooctylbromide (PFOB) partial liquid ventilation (PLV) in infants with severe Bronchopulmonary Dysplasia (BPD).
- Trial name
- FFLOAT (NCT03041740)
- Testing
- Perfluorooctyl Bromide
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital of Philadelphia
ECMO Outcomes, Respiratory Failure (Pediatric Patients)
ECMO Use in Pediatric Oncology and HSCT Patients: A Descriptive and Comparative Analysis
This was an observational study, with a descriptive and comparative portion. The descriptive analysis, a large single center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under…
- Conditions
- ECMO Outcomes, Respiratory Failure (Pediatric Patients), Malignancies, Hematologic, Solid Tumor Malignancies
- Trial name
- NCT07712835
- Testing
- Extracorporeal membrane oxygenation (ECMO)
- Volunteers
- 22 people
- Sponsor
- Children's Mercy Hospital Kansas City
ECMO and Acute MI
Use of ECMO in Acute MI
ECMO offers an acceptable cardiopulmonary support in adults with similar hospital survival rates as other mechanical support. It is versatile and salvages some patients, who may otherwise die.
- Trial name
- NCT00425685
- Volunteers
- 60 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cerebral Oxygenation, Premature
Evaluation of Cerebral Oxygenation Results in Premature Infant
The general purpose of this project is; Evaluation of cerebral oxygenation results in premature infants. These results will be evaluated in two different applications.
- Conditions
- Cerebral Oxygenation, Premature, Kangaroo Care, Facilitated Tucking
- Trial name
- NCT04725435
- Testing
- Kangaroo care, Facilitated Tucking Position
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Hypoxic-Ischemic Encephalopathy Mild
Predictive Value of aEEG and Cerebral Oxygenation on Neurological Outcomes in Newborns With Mild Hypoxic-Ischemic Encephalopathy
Newborns with mild hypoxic-ischemic encephalopathy usually do not receive cooling treatment. However, some of these newborns may develop neurological problems later in life.
- Trial name
- NCT07393620
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Uludag University