Clinical trials: PERIODONTAL DISEASE
Heart Transplant, Periodontitis
Effect of Non-Surgical Periodontal Therapy on Inflammation in Heart Transplant Recipients
Heart transplant recipients frequently exhibit chronic low-grade systemic inflammation, which can contribute to allograft dysfunction and cardiovascular complications.
- Conditions
- Heart Transplant, Periodontitis, Gingivitis, Systemic Inflammation
- Trial name
- NCT07791927
- Testing
- Full-mouth periodontal debridement
- Volunteers
- 20 people
- Sponsor
- Baskent University
Caries, Dental, Periodontal Diseases
The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong
This project aims to evaluate the relative efficacy of a peer-led intervention based on the Social Cognitive Theory and Health Belief Model versus the control (only pamphlet delivery) on increasing the prevalence of healthy oral…
- Trial name
- NCT03694496
- Testing
- peer-led theory-based intervention group
- Where
- Hong Kong
- Volunteers
- 1,184 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Tooth Loss
3D Autotransplantation of Teeth
The study aims to clarify the usefulness of 3D-printed replicas in association with autotransplantation of teeth in children and young adults.
- Trial name
- NCT04120688
- Testing
- 3D generated tooth replica
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Turku University Hospital
Apical Periodontitis, Necrotic Primary Molars
Comparative Evaluation of Antimicrobial Efficacy, Clinical and Radiographic Success of Calcium Hydroxide, Chlorhexidine, and Modified Triple Antibiotic Paste in Different Combination Forms As Intracanal Medicaments Against Enterococcus Faecalis in Primary Teeth
Comparing between different intracanal medications with different combination forms of Modified Triple Antibiotic Paste, Calcium Hydroxide and Chlorehexidine, regarding antimicrobial efficacy through bacterial reduction count of…
- Conditions
- Apical Periodontitis, Necrotic Primary Molars, Periapical Pathosis of Primary Molars
- Trial name
- NCT06625645
- Testing
- Modified triple antibiotic paste (TAP) mixed with chlorehexidine, Modified Triple Antibiotic Paste mixed with saline, Calcium Hydroxide mixed with chlorohexidine Intracanal medication
- Volunteers
- 32 people
- Sponsor
- Mahy Abdel Raouf Aly Kamar
Obesity, Obesity, Childhood
Associations Between Obesity, Dental Caries, Erosive Tooth Wear and Periodontal Disease in Adolescents: A Case Control-study
Objectives To compare oral health (dental caries, periodontal status, and erosive tooth wear (ETW)), diet and oral hygiene habits between obese and normal weight adolescents, and to explore possible risk associations.
- Conditions
- Obesity, Obesity, Childhood, Tooth Wear, Tooth Erosion
- Trial name
- NCT05146557
- Testing
- Dental examination
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Ghent
Gingival and Periodontal Disease, Space Maintenance
The Effects of Fixed Space Maintainers Luting with Self-Adhesive Resin Cement on the Gingival Crevicular Fluid of Interleukin-18 Level
Background:In pediatric dentistry, fixed space maintainers are crucial for preserving the space in edentulous areas following premature tooth loss and promoting the healthy development of the dental arch, maxilla, and mandibula.
- Conditions
- Gingival and Periodontal Disease, Space Maintenance, Resin Cements, Interleukin
- Trial name
- NCT06811597
- Testing
- Voco Meron Conventional Glass Ionomer, High-Q-Bond Band™ self-adhesive resin cement.
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Afyonkarahisar Health Sciences University
Epulis
Histological/ Immunohistological and Molecularpathological Types of Epulides and Central Giant Cell Lesions of the Jaws
This retrospective study will evaluate the patient collective of the Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health and of the Division of Cranio-Maxillofacial Surgery at the Medical…
- Trial name
- NCT03829059
- Where
- Austria
- Volunteers
- 83 people
- Sponsor
- Medical University of Graz
Periodontitis
Osseous Resective Surgery Vs Conservative Surgery with or Without Papilla Preservation Technique
The primary aim of the study is to evaluate the efficacy of either fibre retention osseous resective surgery (FibReORS) or conservative surgery with or without PPT in the treatment of deep residual pockets ≥ 6 mm in stage III-IV…
- Trial name
- FibReORS vs AF (NCT06663202)
- Testing
- Fiber retention osseous resective surgery, Papilla preservation flap, Widman flap procedure
- Volunteers
- 120 people
- Sponsor
- University of Turin, Italy
Chronic Periodontitis
The Effect of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients
To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal…
- Trial name
- NCT03923829
- Testing
- Zinc Sulfate, scaling and root planing
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Abdominal Aorta Aneurism, Periodontitis
Clinical and Microbiological Relationships Between Periodontitis and Abdominal Aorta Aneurism: an Case Control Study
Aorta Abdominal aneurism (AAA) is a chronic degenerative disorder leading to the dilation and eventually to the rupture of the aortic wall.
- Conditions
- Abdominal Aorta Aneurism, Periodontitis, Dentulous
- Trial name
- NCT03767023
- Testing
- cross sectional
- Volunteers
- 61 people
- Sponsor
- University of Liege
Apical Periodontitis
N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as…
- Trial name
- NAC (NCT07262554)
- Testing
- Calcium hydroxide (Ca(OH)₂), N-Acetylcysteine (NAC)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Aggressive Periodontitis
Doxycycline in the Treatment of Aggressive Periodontitis
The aim of the study was to compare the clinical effects of systemic use of doxycycline to amoxicillin plus metronidazole as adjunctive treatment in nonsurgical debridement of aggressive periodontitis (AgP).
- Trial name
- NCT03727620
- Testing
- amoxicillin plus metronidazole, Doxycycline
- Where
- Morocco
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mohammed V Souissi University
Oral Hygiene, White Spot Lesion
Effects of Active Reminders and Motivational Techniques on Oral Hygiene and Gingival Health in Orthodontic Patients
This study will compare the use of text message reminders versus multiple in-person sessions of oral hygiene instructions and motivation on improving oral hygiene measurements.
- Conditions
- Oral Hygiene, White Spot Lesion, Gingivitis
- Trial name
- NCT03841825
- Testing
- Oral hygiene instructions
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Periodontal Disease, Periapical Disease
Periodontal and Periapical Inflammation and Pregnancy
This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study.
- Conditions
- Periodontal Disease, Periapical Disease, Pregnancy, Diabetes
- Trial name
- NCT00490165
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roger Johnson
Periodontal Diseases, Pregnancy Complications
Oral Health and Adverse Pregnancy Complications
Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected.
- Conditions
- Periodontal Diseases, Pregnancy Complications, Pregnancy Preterm, Gestational Diabetes
- Trial name
- NCT06110143
- Testing
- Periodontal treatment
- Where
- 3 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Aggressive Periodontitis
The Affect of Orthodontic Treatment on the Periodontal Status of Patients With Aggressive Periodontitis
Orthodontic Treatment will affect the periodontal status of periodontally treated Aggressive Periodontitis patients.
- Trial name
- NCT01510808
- Testing
- orthodontic treatment
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Hadassah Medical Organization
Gastroesophageal Reflux, Dental Erosion
Relationship and Pathophysiology of Gastroesophageal Reflux and Dental/Periodontal Disease
This study investigates the prevalence and pathophysiology of dental and periodontal involvement in pediatric patients with symptomatic or asymptomatic gastroesophageal reflux (GER) or gastroesophageal reflux disease (GERD).
- Trial name
- NCT01167543
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Periodontal Disease, Type 2 Diabetes Mellitus
Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population
Our overall hypothesis is that treatment of periodontal disease will produce better diabetes glycemic control (glycated hemoglobin A1c, or HbA1c) and reduced levels of the catalytically active form of matrix metalloproteinase…
- Trial name
- NCT01798225
- Testing
- Doxycycline
- Volunteers
- 113 people
- Sponsor
- Medical University of South Carolina
Dental Plaque, Gingivitis
An Investigation of the Efficacy of OHEM for Improving Oral Hygiene in Children
This pilot study evaluates the feasibility of conducting a larger Randomized Controlled Trial to compare three oral health education delivery methods to a control group.
- Trial name
- NCT06356402
- Testing
- Oral Health Educational Module for Mothers (OHEM) lecture, Oral Health Educational Module for Mothers (OHEM) exhibition, Oral Health Educational Module for Mothers (OHEM) demonstration
- Where
- Pakistan
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Ziauddin University
Rheumatoid Arthritis, Periodontitis
Relationship of Periodontitis and Cardiovascular Risk in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is one of the most common autoimmune inflammatory arthritis affecting 0.5 to 1% population worldwide characterized by synovitis, increased inflammatory markers and progressive bone and cartilage erosion.
- Trial name
- NCT03506165
- Testing
- Periodontal treatment
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University