Clinical trials: POTS
Dysautonomia, Anxiety
Implementation of Transdx Group for POTS
The proposed intervention is focused on developing and implementing a psychological approach incorporated into a group-based outpatient intervention for pediatric autonomic dysfunction.
- Conditions
- Dysautonomia, Anxiety, Depression
- Trial name
- NCT03185247
- Testing
- Transdiagnostic Group-Based Treatment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Postural Tachycardia Syndrome, Syncope
Qualitative Sweat Distribution During Tilt Table Procedure
This study uses an Alizarin Red powder mixture to characterize the sweat distributions in youth during tilt table testing. Patients with a known orthostatic sweat response from a prior clinical tilt table test in the…
- Conditions
- Postural Tachycardia Syndrome, Syncope, Anxiety
- Trial name
- NCT02329548
- Testing
- Alizarin Red
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Nationwide Children's Hospital
Postural Orthostatic Tachycardia Syndrome (POTS), Syncope
Abdominal and Lower Extremity Compression During Tilt Table Testing in Adolescent POTS Patients
Postural orthostatic tachycardia syndrome (POTS) is a common cause of orthostatic intolerance in adolescents and adults. Compression stockings are commonly recommended as a treatment modality for POTS, but the effects of…
- Trial name
- NCT01795469
- Testing
- Zoex compression garment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nationwide Children's Hospital
POTS
Physical Activity as a Complementary Treatment in POTS
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic…
- Trial name
- POTS (NCT04702217)
- Testing
- Training program
- Where
- Sweden
- Sponsor
- Lund University
Postural Tachycardia Syndrome, Autonomic Dysfunction
Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS)
The purpose of this study is to determine if nVNS will decrease autonomic symptom intensity (COMPASS-31 and Child Functional Disability Inventory) in adolescent patients with postural orthostatic tachycardia syndrome (POTS) in…
- Conditions
- Postural Tachycardia Syndrome, Autonomic Dysfunction, Postural Orthostatic Tachycardia Syndrome, POTS - Postural Orthostatic Tachycardia Syndrome
- Trial name
- NCT06268288
- Testing
- GammaCore intervention, STEPS management protocol
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Syncope, Postural Tachycardia Syndrome
EEG Characteristics in Youth POTS and/or Syncope
Orthostatic intolerance refers to symptoms that occur with standing and improve or resolve with recumbency. Few studies have evaluated orthostatic intolerance symptoms by electroencephalography (EEG), and none of those studies…
- Conditions
- Syncope, Postural Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- NCT02167412
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Nationwide Children's Hospital
Postural Orthostatic Tachycardia Syndrome (POTS), POTS
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
Postural tachycardia syndrome (POTS), is the chronic form of orthostatic intolerance associated with excessive upright tachycardia, and occurs predominantly in young females (>85%).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), POTS, Orthostatic Intolerance
- Trial name
- NCT03261570
- Testing
- Pyridostigmine, Digoxin
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Postural Tachycardia Syndrome
POTS NET mRNA Functional Correlation With NET Activity
DNA Acetylation can be responsible for significant down-regulation of transcription of the Norepinephrine Transporter (NET). NET is an important clearance transporter that removes norepinephrine (NE) from sympathetic neuronal…
- Trial name
- NCT03218761
- Testing
- NET mRNA level, Plasma catechols, Urine Catechols
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Postural Tachycardia Syndrome
Local Vasoconstriction in Postural Tachycardia Syndrome
The investigators study will determine how often blood flow regulation abnormalities and abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and oxidative stress occur in POTS and the mechanism(s) of…
- Trial name
- NCT01210430
- Testing
- Losartan, Ascorbic Acid (Vitamin C), Normal Saline
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Postural Orthostatic Tachycardia Syndrome, Hypocapnia
Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome With Orthostatic Hyperpnea and Hypocapnia
Postural tachycardia syndrome (POTS) is the most common chronic cause of postural lightheadedness, and upright confusion afflicting many Americans, mostly young women.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Hypocapnia, Hyperventilation
- Trial name
- NCT05923840
- Testing
- Chemoreflex Testing, Baroreflex testing, Orthostatic stress testing
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Postural Orthostatic Tachycardia Syndrome
Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)
This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.
- Trial name
- NCT06292104
- Testing
- multimodal diagnostic testing
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Postural Tachycardia Syndrome
Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Natural History With Its Numerous Co-morbidities?
This study is being conducted to see how people with Postural tachycardia syndrome (POTS) make sense of the things they see. The information may help doctors to learn more about how the different parts of people's brains…
- Trial name
- NCT05618054
- Testing
- Looming task
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Syncope
Evaluation of Chronic Orthostatic Intolerance
This study will conduct tests with patients with primary chronic orthostatic intolerance (COI) to learn more about this disorder of the autonomic nervous system.
- Trial name
- NCT00069693
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
We and others have shown that many younger patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have orthostatic intolerance (OI), i.e., they can't tolerate prolonged standing.
- Conditions
- Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS)
- Trial name
- NCT02854683
- Testing
- Normal Saline, Oral Rehydration Solution
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Postural Orthostatic Tachycardia Syndrome
CRI in POTS in Adolescents
The investigators aim to study whether the Compensatory Reserve Index (CRI) (an FDA approved device that assesses intravascular volume) can be used to evaluate severity of Postural Orthostatic Tachycardia Syndrome (POTS) and…
- Trial name
- POTS (NCT03974737)
- Testing
- CRI device (non-invasive vitals sign measurement)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ehlers Danlos Syndrome, External Hydrocephalus
Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life
It is known that 33-50% of Classic and Hypermobile Ehlers-Danlos Syndrome patients eventually develop dysautonomia, otherwise known as "POTS" (Postural Orthostatic Tachycardia Syndrome).
- Conditions
- Ehlers Danlos Syndrome, External Hydrocephalus, Dysautonomia, Postural Orthostatic Tachycardia Syndrome
- Trial name
- NCT01367977
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Genetic Disease Investigators
Postural Orthostatic Tachycardia Syndrome
Iron Sucrose in Adolescents With Iron Deficiency and Postural Orthostatic Tachycardia Syndrome (POTS)
This study is designed to investigate whether the treatment of non-anemic iron deficiency with intervenous iron sucrose will result in decreased symptom reporting and improved cardiovascular indices in adolescents (age 12-21)…
- Trial name
- NCT01978535
- Testing
- Iron infusion, Normal saline infusion
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Vasovagal Syncope, Postural Tachycardia Syndrome
Hypnosis in Autonomic Function
This study will investigate the relationship between susceptibility to hypnosis and regulation of the autonomic nervous system (nerves that control involuntary body functions, such as heart rate and sweating).
- Conditions
- Vasovagal Syncope, Postural Tachycardia Syndrome, Hypnosis
- Trial name
- NCT00061009
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke Recurrence, Cardiovascular Events
Post-stroke Depression Treatment Effect on Stroke Recurrence
It is not clear whether depresssion can predispose, or precipitate stroke recurrence in patients with stroke. We sought the relationship of post stroke depression with stroke recurrence.
- Conditions
- Stroke Recurrence, Cardiovascular Events, Depression
- Trial name
- STROKE (NCT04776226)
- Testing
- Citalopram
- Where
- Turkey (Türkiye)
- Volunteers
- 1,230 people
- Sponsor
- Ege University
Vomiting Syndrome, Irritable Bowel Syndrome
Autonomic Profiles in Pediatric Patients With Cyclic Vomiting Syndrome (CVS), Irritable Bowel Syndrome (IBS),Postural Orthostatic Tachycardia Syndrome (POTS), Functional Abdominal Pain (FAP) or Chronic Nausea
Retrospectively review the charts of all children who had heart rate variability, deep breathing test, valsalva maneuver, tilt table test, thermoregulatory sweat testing, quantitative sudomotor axon reflex test (QSART) completed…
- Conditions
- Vomiting Syndrome, Irritable Bowel Syndrome, Postural Orthostatic Tachycardia Syndrome, Abdominal Pain
- Trial name
- NCT00728026
- Volunteers
- 19 people
- Sponsor
- Medical College of Wisconsin