Clinical trials: Pain Control
Degenerative Disc Disease Lumbar, Spinal Stenosis
Multimodal Analgesia Versus Routine Care Pain Management
Most patients undergoing surgery experience significant post-operative pain. Inadequate peri-operative pain management may decrease post-operative mobilization and increase length of hospitalization.
- Conditions
- Degenerative Disc Disease Lumbar, Spinal Stenosis, Lumbar Spondylolisthesis
- Trial name
- MMA (NCT01861743)
- Testing
- Multimodal Analgesia, Patient controlled analgesia
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Anesthesia
Comparing Dexmedetomidine With Bupivacaine Versus Bupivacaine Alone for Caudal Block in Supra - Umbilical Surgeries
dexmedetomidine is an alpha 2 adrenergic receptor agonist that is given either systemically or combined to local anesthetics during regional blocks.
- Trial name
- NCT03307590
- Testing
- Dexmedetomidine, Bupivacaine
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Pediatric Obesity, Lower Extremity Biomechanics
Training Induced Reduction of Lower-limb Joint Loads During Locomotion in Obese Children
Childhood obesity is one of the most critical and accelerating health challenges throughout the world. It is a major risk factor for developing varus/valgus misalignments of the knee joint.
- Trial name
- NCT02545764
- Testing
- Strength and neuromuscular exercise programme
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- St. Pölten University of Applied Sciences
Hemorrhage
The Effect of Tranexamic Acid on Postpartum Hemorrhage During and After Cesarean Delivery
Intravenous Tranexamic acid is used to reduce the hemorrhage during and after cesarean delivery in a double blind randomized placebo controlled trial.
- Trial name
- NCT01085006
- Testing
- Tranexamic acid, Normal saline
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Musculoskeletal Injury
Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries
Musculoskeletal (MSK) injuries, including limb injuries, are the most common cause for Emergency Department (ED) visits for children with pain.
- Trial name
- No OUCH (NCT03767933)
- Testing
- Ibuprofen, Acetaminophen, Hydromorphone
- Where
- 6 sites in Canada
- Volunteers
- 710 people
- Sponsor
- University of Alberta
Endodontic Inflammation
Evaluation of the Effect of Different Irrigation Activation Methods During Endodontic Retreatment
The persistent and secondary intraradicular infections are the primary causes of post-treatment disease following endodontic treatment of any tooth.
- Trial name
- NCT07779148
- Testing
- Xp Finisher R file
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Minia University
Office Hysteroscopy
Pain Management During Diagnostic Office Hysteroscopy in Postmenopausal Women: a Randomized Study
To assess the effectiveness of lidocaine-prilocaine spray versus placebo in minimizing the pain experienced by postmenopausal patients during diagnostic office hysteroscopy and to assess the ease of insertion of hysteroscope as…
- Trial name
- NCT06767085
- Testing
- Lidocaine-Prilocaine Topical, Saline spray
- Volunteers
- 106 people
- Sponsor
- Cairo University
Immunisation Anxiety Related Reaction
Feasibility of Implementation of CARD for School-Based Immunizations
A multi-faceted knowledge translation intervention - The CARD (C-Comfort, A-Ask, R-Relax, D-Distract) System - was developed to improve the vaccination experience of students at school.
- Trial name
- NCT03948633
- Testing
- Multi-faceted knowledge translation intervention
- Where
- Canada
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Bariatric Surgery
The Effect of Guided Imagery on Bariatric Surgery Patients
The study will be conducted using a randomized controlled experimental design with experimental and control groups. Data will be collected between August 2025 and March 2026 in the General Surgery Clinic of Erzurum City Hospital.
- Trial name
- NCT07157826
- Testing
- Guided Imagery Application
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Intravenous Injections, Vaccination
Efficacy of the Buzzy® Device on the Prevention of Health Care Induced Pediatric Pain in a Vaccination Center
In vaccination centers, venipunctures and vaccinations are sources of pain and anxiety in pediatric patients. Prior painful experiences can reduce the acceptance of later health care, hence making it more difficult for both…
- Trial name
- DOLVAX (NCT03220555)
- Testing
- Buzzy® device, EMLAPATCH (lidocaine, prilocaine)
- Where
- 3 sites in France
- Volunteers
- 220 people
- Sponsor
- Nantes University Hospital
Pain
S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Vascular Access Procedures in Children
The pain associated with medical procedures is often under-treated in children. Children often undergo painful procedures with little or no anesthetic, even when effective therapy is available.
- Trial name
- NCT00125255
- Testing
- S-Caine™ Peel (lidocaine and tetracaine cream 7%/7%)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- ZARS Pharma Inc.
Complicated Appendicitis
Causes of Complicated Appendicitis at Referral Hospital
The study was conducted on a medical record of previously treated patients for acute appendicitis at HFSUH, Harar, Ethiopia. The study design was case-control with a total sample size of 402.
- Trial name
- AA (NCT05005104)
- Where
- Ethiopia
- Volunteers
- 402 people
- Sponsor
- Haramaya Unversity
Post Operative Pain, Spinal Fusion
Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine
A randomized controlled trial (RCT) investigating whether the local anesthetic injection of liposomal bupivacaine during posterior spinal fusion (PSF) for AIS is more effective in reducing acute postoperative opioid consumption…
- Trial name
- NCT06471348
- Testing
- Bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride and Epinephrine Injection
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Boston Children's Hospital
Sciatica
Topiramate in the Treatment of Sciatica
This study will test the effectiveness of topiramate to treat pain caused by lumbar radiculopathy, or sciatica. Sciatica results from damage to the lumbar nerve roots, typically causing back pain and sharp, shooting pain down one…
- Trial name
- NCT00011804
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Pain
Evaluation of the Effectiveness of the Use of the Therapeutic Bandage Method in Third Molar Surgery
Extraction of lower third molars semi-included or included is one of the most performed procedures in oral surgery, and inherent to the procedure there is a postoperative inflammatory response.
- Trial name
- NCT03393533
- Testing
- Group I, Group II
- Where
- Brazil
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Apical Periodontitis
The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study
The main purpose of this study is to evaluate the effect of Mesenchymal Stem Cells (MSCs) isolated from the umbilical cord and exosomes derived from these cells on the success of the treatment in the regenerative endodontic…
- Trial name
- NCT06764004
- Testing
- Stem Cell Product, Bleeding and clots
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Anxiety, Dental
Comparative Evaluation Between the Effectiveness of Vibration Assisted Syringe and Conventional Syringe
The study will be conducted to evaluate the effect of the vibration assisted syringe on pain perception and anxiety in children during intra oral injection of local anesthesia in comparison with conventional syringe.
- Trial name
- NCT04215055
- Testing
- vibraject
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain Management, Fear and Anxiety
Virtual Reality for Pain, Fear, and Physiological Responses During Pediatric Venous Catheterization
This study aims to evaluate the effect of two different virtual reality (VR) applications on children's pain, fear, and physiological parameters during peripheral intravenous catheterization.
- Trial name
- VR-PainKids (NCT07202468)
- Testing
- Virtual Reality
- Volunteers
- 150 people
- Sponsor
- Ege University
Pregnancy Complications, Atelectasis
Effect of Epidural Analgesia on Regional Lung Ventilation in Parturient Women as Assessed by Thoracic Impedance
The goal of this observational study is to learn more about the effect of obstetric epidural anesthesia on regional lung ventilation in healthy parturient women.
- Trial name
- NCT06195774
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.