Clinical trials: Pain Severity
Pain
Efficacy of Topical Lidocaine to Decrease Discomfort With Intranasal Midazolam Administration
The purpose of this study was to establish whether premedication with topical lidocaine would reduce the pain associated with IN midazolam administration in children.
- Trial name
- NCT02396537
- Testing
- Lidocaine, Midazolam, 0.9% Saline
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Dietary and Exercise Interventions in Reducing Side Effects in Patients With Stage I-IIIa Breast Cancer Receiving Aromatase Inhibitors
This phase I/II trial studies how well dietary and exercise interventions work in reducing side effects in patients with stage I-IIIa breast cancer taking aromatase inhibitors.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT03953157
- Testing
- Dietary Intervention, Exercise Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Dyspepsia, Emergency
Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole
The purpose of this study is to evaluate the immediate synergistic effect on the relief of severe acid-related dyspeptic pain by adding intravenous pantoprazole to the combination of oral antacid and antispasmodic agent (the…
- Conditions
- Dyspepsia, Emergency, Pain
- Trial name
- NCT01281501
- Testing
- Normal saline, Pantoprazole, Oral antacid
- Where
- Thailand
- Volunteers
- 87 people
- Sponsor
- Chulalongkorn University
Cerebral Palsy, Hip Dysplasia
Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy
Pain management in pediatric patients presents a difficult challenge. Unlike adults, pediatric patients often cannot communicate their pain management needs clearly.
- Conditions
- Cerebral Palsy, Hip Dysplasia, Pain, Postoperative
- Trial name
- NCT06189781
- Testing
- Ropivacaine injection, Bupivacaine, lidocaine, ropivacaine
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Femoral Neck Fractures
Effect of Local Infiltration Anesthesia With Ropivacaine on Postoperative Pain After Hip Hemiarthroplasty
At St.Olavs Hospital each year about 400 patients are treated for femoral neck fractures, 250 of them receiving hemiarthroplasty.
- Trial name
- NCT02585011
- Testing
- Ropivacaine, Epinephrine, Saline
- Where
- Norway
- Volunteers
- 123 people
- Sponsor
- St. Olavs Hospital
Chronic Pain
Ganglion Impar Denervation and Radiofrequency on Sacral Root 3 for Chronic Prostatic Pain
the authors will evaluate the added analgesic benefit of pulsed radiofrequency on sacral root 3 with ganglion impar denervation on chronic pelvic pain due to chronic prostatitis
- Trial name
- NCT03884764
- Testing
- pulsed radiofrequency, ganglion impar denervation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Regional Anesthesia, Pediatric Anesthesia
Continous Lumbar Plexus Block in Children
Randomised controlled prospective trial with 2 groups (active group with Lumbar plexus block (LPB)-catheter vs control group). In a randomized controlled trial, the investigators will investigate under controlled circumstances…
- Conditions
- Regional Anesthesia, Pediatric Anesthesia, Pain, Postoperative
- Trial name
- NCT03450096
- Testing
- LPB
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pain, Acute
Distraction as Treatment for Pain in Children in Resource-scarce Settings
Pain alleviation in pediatric patients can be challenging for medical professionals working in resource scarce settings due to limited availability of medication, monitoring equipment, or training in this field of expertise.
- Trial name
- DISTRACT (NCT06933303)
- Testing
- Distraction with kaleidoscope
- Where
- South Africa
- Volunteers
- 126 people
- Sponsor
- Vrinnevi Hospital
Breast Cancer, Musculoskeletal Complications
S1202: Duloxetine Hydrochloride for Muscle/Joint Pain in Early-Stage Breast Cancer Receiving Hormone Therapy
RATIONALE: Duloxetine hydrochloride may lessen muscle, bone, and joint pain caused by hormone therapy. It is not yet known whether duloxetine hydrochloride is more effective than a placebo in treating patients with muscle, bone…
- Conditions
- Breast Cancer, Musculoskeletal Complications, Pain
- Trial name
- NCT01598298
- Testing
- duloxetine hydrochloride
- Where
- 714 sites in United States
- Volunteers
- 299 people
- Sponsor
- SWOG Cancer Research Network
Postoperative Pain
Laryngoscope Force During Suspension for Adenotonsillectomy
Suspension laryngoscopy is a common procedure during adenoteonsillectomy (removal of adenoids and tonsils), that consists of extending the patient's neck to allow better visualization of the tonsils.
- Trial name
- NCT06115798
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Autism Spectrum Disorder (ASD), Pain Perception
Quantitative Sensory Testing to Study Pain Perception in Autism
This study aims at assess sensory perception, and pain perception, in neurodivergent children and adolescent in the autism spectrum.
- Trial name
- PPiA (NCT06659731)
- Testing
- Quantitative Sensory testing (QST), EEG
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Pain, Monitoring, Intraoperative
Evaluation of the Pupil Dilation Reflex in Response to Noxious Stimulation in Anaesthetized Children. A Proof of Concept Trial
After conduction a pilot study, pupillary dilation reflex (PDR) is measured in response to nociceptive stimulation perioperatively in infants, children and adolescents.
- Trial name
- Pain@OR-kids (NCT03449732)
- Testing
- PDR measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Chronic Pain, Mental Disorder
Early Detection of Mental Disorders in Adolescents With Chronic Pain: Creation of a Screening Tool for Use by the General Practitioner
This research aims to create a tool for detection of mental health disorders in adolescents with chronic pain. The first part is testing a screening questionnaire and comparing in with existing questionnaires.
- Trial name
- REPERADO (NCT04467229)
- Testing
- Focus group
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Degenerative Disc Disease, Degenerative Spondylolisthesis
The Five-repetition Sit-to-stand Test for Lower Back Pain or Radiculopathy
The five-repetition sit-to-stand test (5R-STS) has been used in many medical disciplines, but has never been correlated with or validated in regard to degenerative spinal diseases.
- Conditions
- Degenerative Disc Disease, Degenerative Spondylolisthesis, Herniated Disc, Stenosis, Spinal
- Trial name
- 5R-STS (NCT03303300)
- Where
- Netherlands
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Marc Schröder
Gastroparesis, Dyspepsia
Longitudinal Evaluation of Gastric Emptying and Accommodation in Children With Dyspepsia
The purpose of this research is to further study the relationship between gastroparesis (GP) (a condition in which the stomach cannot empty itself of food in a normal fashion) and functional dyspepsia (FD) (frequent symptoms of…
- Trial name
- NCT05055336
- Testing
- Gastric emptying breath test, Stomach ultrasound
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Orthodontic Extraction, Orthodontic Treatment
A Comparative Assessment of Post Extraction Pain in Orthodontic Patients to Evaluate the Effects of Early Engagement of Tooth with Orthodontic Wires. a Single Center Randomized Clinical Trial (RCT)
The goal of this clinical trial is to determine if the timing of tooth extractions (before or after initial orthodontic treatment) affects pain levels in patients who need bilateral extractions of first premolars in the upper…
- Conditions
- Orthodontic Extraction, Orthodontic Treatment, Orthodontic Treatment Via Premolar Extraction
- Trial name
- NCT06582836
- Testing
- The objective of the study was to investigate the effect of prior engagement of tooth with orthodontic appliance on post extraction pain among orthodontic patients
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Class II Malocclusion
Evaluation of the Levels of Pain, Discomfort, and Functional Impairment With Two Techniques of Retraction
Thirty-eight patients requiring extraction of maxillary first premolars will participate in the study. They will be divided randomly into two groups: an en-masse retraction group and a two-step group.
- Trial name
- NCT05652244
- Testing
- Mini-implants, Transpalatal arche (TPA)
- Where
- Syria
- Volunteers
- 38 people
- Sponsor
- Damascus University
Pain, Postoperative, Phimosis
An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision
Circumcision is the most common surgical procedure performed by Pediatric Urologists. Ketorolac has been shown to have an efficacy similar to morphine in multi-modal analgesic regimens without the commonly associated adverse…
- Conditions
- Pain, Postoperative, Phimosis, Paraphimosis, Balanitis
- Trial name
- NCT04646967
- Testing
- Bupivacain, Sevoflurane, Acetaminophen
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Fingertip Amputation, Finger Injuries
Semi-occlusive Dressing for Pediatric Fingertip Amputations
The aim of this prospective cohort study is to assess the outcome and pain progression of fingertip (partial) amputations treated with a semi-occlusive wound dressing (regular care) in childhood and adolescence.The main questions…
- Trial name
- NCT07552753
- Testing
- semi-occlusive dressings
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
Migraine, Headache
The Role of CGRPand Nociceptin in Migraine
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was…
- Trial name
- NCT00155129
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
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