Clinical trials: Paracetamol
Pain, Postoperative, Dental Pain
A Study of Acetaminophen for Post Surgical Dental Pain
To assess the safety, tolerability, analgesic, efficacy and pharmacokinetics of high dose acetaminophen relative to placebo and low dose acetaminophen relative to placebo over a 24 hour period in patient experiencing moderate to…
- Trial name
- NCT04018612
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
SMA II, Cerebral Palsy
Paracetamol Study in Patients With Low Muscle Mass
To investigate the safety and toxicity related to paracetamol treatment in children and adults with respectively SMA and CP.
- Trial name
- NCT03648658
- Testing
- Paracetamol 120Mg/5mL Oral Suspension
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mette Cathrine Oerngreen
Acetaminophen Overdose
Safety and Efficacy Study of a New Formulation of Acetylcysteine Injection
The primary purpose of this study is determine if a new formulation of Acetadote is at least as effective as the current formulation in the prevention and treatment of acetaminophen overdose related liver injury.
- Trial name
- NCT01118663
- Testing
- Acetadote EF (Ethylenediaminetetraacetic Acid (EDTA) - Free), Acetadote
- Where
- 14 sites in United States
- Volunteers
- 17 people
- Sponsor
- Cumberland Pharmaceuticals
Asthma
The Effect of Single Dose Paracetamol on the Lower Airways of Asthmatic and Healthy Children
Asthma is a common inflammatory airway disease. Several researches have demonstrated a possible connection between asthma and exposure to paracetamol.
- Trial name
- NCT01073748
- Testing
- paracetamol
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Orthodontic Pain
Acetaminophen Versus Ibuprofen for the Control of Immediate and Delayed Pain Following Orthodontic Separator Placement
The purpose of this research study is to compare pain control effectiveness of two medicines and a placebo (a dummy pill that does not contain any pain relieving medication) to see which one works better at preventing pain when…
- Trial name
- NCT00484744
- Testing
- Acetaminophen, Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Missouri, Kansas City
Pain and Discomfort, Orthodontic Appliance Complication
The Role of Paracetamol-caffeine and Laser Irradiation on Controlling Pain and Discomfort During Orthodontic Treatment
Patients with class I malocclusion who have mild to moderate crowding will be treated in this study. The efficacy of low level laser therapy and Panadol-extra® in relieving pain due to orthodontic treatment will be assessed.
- Trial name
- NCT03400111
- Testing
- low-level laser therapy, Panadol-extra
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
Pain, Fever
Study of the Safety & Efficacy of Intravenous Acetaminophen in Pediatric Inpatients
Intravenous acetaminophen (IVAPAP) is safe in repeated dose, multi-day clinical use when administered at a daily dose of 40 to 75 mg/kg body weight
- Trial name
- NCT00598702
- Testing
- IV Acetaminophen
- Where
- 14 sites in United States
- Volunteers
- 100 people
- Sponsor
- Mallinckrodt
Acetaminophen,Mechanical Ventilation,Critically Ill Children
Clinical Efficacy of Acetaminophen in Mechanical Ventilation in Children With New Coronary Pneumonia
Patients were randomized to receive either paracetamol during mechanical ventilation. When patients were randomized to receive paracetamol (40 mg/kg per day in 4 doses), a placebo infusion of normal saline was administered…
- Trial name
- NCT05691088
- Testing
- Paracetamol injection
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Second Clinical Medical College of Jinan University
Labour Duration
Intravenous Paracetamol Versus Intramuscular Tramadol in Shortening the Duration of Labour.
It is a well established fact that the pain of labour can be excrutiating and ways to shorten the duration of labour has been sought after.
- Trial name
- NCT07394491
- Testing
- paracetamol, Tramadol hydrochloride
- Where
- Nigeria
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Federal Teaching Hospital Abakaliki
Post Mastectomy Pain Syndrome
Comparison Between Pregabalin and Acetaminophen for the Treatment of Post-Mastectomy Pain Syndrome
The goal of this trial is to learn if Pregabalin is better than Acetaminophen in pain management of patients with Post-Mastectomy pain Syndrome, which is defined as pain in the scar, chest wall, shoulder after undergoing…
- Trial name
- NCT07567924
- Testing
- Pregabalin, Acetaminophen
- Where
- Pakistan
- Volunteers
- 158 people
- Sponsor
- Subas Ali
Orthodontic Pain (D013850), Pain Management (D016146)
A Randomized Clinical Trial of the Effectiveness of Acupressure in Relieving Orthodontic Pain
Orthodontic treatment with fixed appliances often causes pain, which peaks within 24 hours after archwire placement and lasts for several days.
- Conditions
- Orthodontic Pain (D013850), Pain Management (D016146), Acupressure (D056351), Analgesics, Non-Narcotic (D000700)
- Trial name
- NCT06812936
- Testing
- Acetaminophen, Acupressure
- Where
- Iraq
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Patent Ductus Arteriosus in Preterm Infants
The Effectiveness of Paracetamol Versus Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Neonates
This study aims to find and compare the effectiveness of paracetamol and ibuprofen in the closure of patent ductus arteriosus in preterm neonates.
- Trial name
- NCT06601114
- Testing
- Paracetamol Group, Ibuprofen group
- Where
- Pakistan
- Volunteers
- 254 people
- Sponsor
- Arooj Khan
Poisoning, Obesity
PBPK Modelling Applied to Acetaminophen Poisoned Obese Children
Childhood obesity is increasing globally. Changes in body composition and physiology in obesity setting modify pharmacokinetic parameters and might increase the risk in case of poisoning.
- Trial name
- IntoxPara (NCT04850014)
- Testing
- Anthropomorphism, Relevant clinical datas
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Common Cold, Influenza
Evaluation of Efficacy and Safety of Oral Solution Resfenol in Reducing Symptoms of Common Cold And Flu
This study aimed to evaluate the efficacy and safety of the oral solution of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in reducing symptoms of flu and the common cold.
- Trial name
- NCT01158326
- Testing
- Resfenol
- Where
- Brazil
- Volunteers
- 216 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Retinopathy of Prematurity, Pain Management
Pain Management During Screening for Retinopathy of Prematurity
Abstract Background: Screening examinations for retinopathy of prematurity (ROP) is critical to reduce ROP-related vision loss, however, the procedure is painful and uncomfortable, and topical anesthetics do not completely…
- Trial name
- NCT04767178
- Testing
- Ibuprofen (Sanofi, Istanbul, Turkey), Paracetamol (GlaxoSmithKline, Istanbul, Turkey)
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Istanbul Medeniyet University
Pediatric Disorder
Comparing the Difference in Pain Control in the Pediatric General Surgery Population: to Alternate or Combine Acetaminophen and Ibuprofen?
To examine the difference in pain control in the pediatric general surgery population alternating acetaminophen and Ibuprofen q 3 hours vs giving them simultaneous combination therapy around the clock.
- Trial name
- NCT06505148
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor Research Institute
Postoperative Pain
A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-183)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
- Trial name
- NCT00092326
- Testing
- MK0966, rofecoxib
- Volunteers
- 269 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Liver Failure, Hepatic Encephalopathy
N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure
We have completed patient enrollment in the the double blind, randomized, placebo-controlled trial of intravenous (IV) N-acetylcysteine (NAC) vs. placebo for the treatment of non-acetaminophen ALF.
- Trial name
- NCT00248625
- Testing
- N-acetylcysteine
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 184 people
- Sponsor
- University of Pittsburgh
Intraventricular Haemorrhage Neonatal
Prophylactic Acetaminophen for Prevention Intraventricular Hemorrhage in Premature Infants
The purpose of this study is to determine whether acetaminophen is effective in prevention or reducing the severity of IVH in premature infants.
- Trial name
- NCT03024814
- Testing
- Acetaminophen, Dextrose 5
- Where
- Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- King Saud Medical City
Headache, Pregnancy Related
Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
This is an open label randomized controlled trial evaluating response to bupivacaine occipital nerve block compared to Tylenol/Caffeine cocktail in treatment of pregnant patients seeking care of headache.
- Conditions
- Headache, Pregnancy Related, Occipital Nerve Block
- Trial name
- NCT03951649
- Testing
- Occipital Nerve Block
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham