Clinical trials: Parkinson Disease(PD)
Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic
Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.
This study is aimed at patients with multi-system atrophy - parkinsonian type (P-MSA) or Parkinson's disease (PD) receiving dopaminergic drugs and suffering from orthostatic hypotension (OH).
- Conditions
- Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic, Parkinson Disease
- Trial name
- CARBIDOH (NCT06831500)
- Testing
- Administration of Carbidopa/levodopa
- Where
- 2 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Julien Bally
Parkinson Disease
Parkinson's Research: The Organized Genetics Initiative
The purpose of this trial is to study genetic and other risk factors that may be important in the development of Parkinson's disease.
- Trial name
- PROGENI (NCT00086073)
- Where
- 58 sites in United States, Canada and 1 more
- Volunteers
- 1,800 people
- Sponsor
- Indiana University
Parkinson Disease
Special Survey on Parkinson's Disease (PD) Patients Without Concomitant Use of L-Dopa
The survey is conducted to collect safety and effectiveness information in Parkinson's Disease patients treated with Pramipexole without concomitant L-Dopa supplementation in the daily clinical settings in Japan.
- Trial name
- NCT00613301
- Where
- 119 sites in Japan
- Volunteers
- 416 people
- Sponsor
- Boehringer Ingelheim
Parkinson Disease, Apathy
Move to Improve Physical Activity in Parkinson's Disease
Apathy is a multi-dimensional behavior characterized by impairments to motivation, planning and initiation; collectively called, goal-directed behavior.
- Trial name
- MoTIvatE (NCT04051151)
- Testing
- Gameficiation
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Pennsylvania
Parkinson's Disease (PD), Anxiety
Blood Flow Restriction Aerobic Exercise for Balance and Anxiety in Parkinson's Disease
Reducing balance problems and anxiety severity are the top two research uncertainties for people with Parkinson's disease (PD). Besides having a mutually aggravating relationship between postural impairment and anxiety severity…
- Conditions
- Parkinson's Disease (PD), Anxiety, Postural Balance
- Trial name
- NCT07831980
- Testing
- Aerobic Exercise with Blood Flow Restriction, Aerobic Exercise without Blood Flow Restriction
- Volunteers
- 54 people
- Sponsor
- National Cheng-Kung University Hospital
Parkinson Disease
Donepezil to Treat Dementia in Parkinson's Disease
This study will evaluate the safety and effectiveness of donepezil (Aricept) for treating mild dementia in patients with Parkinson's disease.
- Trial name
- NCT00030979
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, PD
Genetic Characterization of Parkinson's Disease
This study will explore the risks and causes of Parkinson's disease, a chronic progressive nervous system disorder. Patients typically have tremors, muscle weakness and a shuffling gait.
- Conditions
- Parkinson Disease, PD, Movement Disorder, Healthy Volunteer
- Trial name
- NCT00105131
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease (PD)
An Observational Study of Subcutaneous Infusion of ABBV-951 to Assess Change in Disease Activity and Adverse Events In Adult Japanese Participants With Advanced Parkinson's Disease
Parkinson's disease (PD) is a neurological condition, which affects the brain. Some symptoms of PD are tremors, stiffness, and slowness of movement.
- Trial name
- NCT05916157
- Where
- 17 sites in Japan
- Volunteers
- 250 people
- Sponsor
- AbbVie
Parkinson Disease (PD)
Enhanced Tai Chi for Parkinson's Disease (Enhanced Tai Chi PD)
This pilot study evaluates whether a structured, Parkinson's disease-specific Tai Chi programme ("Enhanced Tai Chi") can improve motor and non-motor symptoms in people with Parkinson's disease (PD).
- Trial name
- ETC-PD (NCT07297368)
- Testing
- Enhanced Tai Chi (Enhanced-Tai-Chi-PD), Usual Treatment (Standard Clinical Care)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Parkinson's Disease (PD), Multiple System Atrophy
Shanghai Clinical Cohort - Parkinson's Disease (Reserve)
The goal of this observational cohort studyis to establish a high-quality clinical cohort of Parkinson's disease (PD) and multiple system atrophy (MSA) patients in Shanghai, in order to improve early diagnosis, precise subtyping…
- Trial name
- NCT07353463
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Ruijin Hospital
Parkinson Disease, Dexterity
Effectiveness of MIRT on Hand and Finger Dexterity in PD Patients
Aims of the study are (1) to evaluate the effectiveness of a specific OT treatment aimed to enhance finger and hand dexterity and (2) its impact on daily living autonomy of PD patients.
- Conditions
- Parkinson Disease, Dexterity, Rehabilitation
- Trial name
- H_F_ D_PD_MIRT (NCT03763955)
- Testing
- MIRT
- Volunteers
- 482 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson Disease, MSA - Multiple System Atrophy
Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease
Clinical diagnosis of Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) is challenging, especially in the early stages.
- Conditions
- Parkinson Disease, MSA - Multiple System Atrophy, Lewy Body Dementia (LBD), Neurodegenerative Disease
- Trial name
- EXTRAORDINARY (NCT06846658)
- Where
- 3 sites in Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
PARKINSON DISEASE (Disorder), Parkinson Disease (PD), Postural Balance
Telerehabilitation Versus Face-to-Face LSVT BIG in Individuals With Parkinson Disease
This prospective, randomized controlled trial will enroll 40 individuals with idiopathic PD (Hoehn \& Yahr stages 1-3, MoCA ≥21).
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson Disease (PD), Postural Balance, Parkinson Disease
- Trial name
- NCT07630792
- Testing
- Face-to-Face LSVT BIG, Telerehabilitation LSVT BIG
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
Parkinson Disease
Deep Brain Stimulation (DBS) Frequency Effects on Gait in Parkinson's Disease(PD)
In this study the investigators will evaluate the effect of both low and high frequency Deep Brain stimulation of the subthalamic nucleus (STN) in Parkinson's patients who have noted a change in their walking.
- Trial name
- NCT00993291
- Testing
- Frequency change to 60 Hz, Frequency change to 130 Hz
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Traumatic Brain Injury, Cerebral Palsy
Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy
This prospective observational study collects real world data on participants receiving regenerative therapies administered internationally and delivered intranasally via the Kurve Therapeutics ViaNase device.
- Conditions
- Traumatic Brain Injury, Cerebral Palsy, Hypoxic Ischemic Encephalopathy, Neurologic Disorders
- Trial name
- MuSE-INSIGHT (NCT07521384)
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Healing Hope International
Parkinson Disease
The Measurement of Nocturnal Hypokinesia in Parkinson's Disease (PD) Patient Compared With Spouse by Wearable Sensors
To quantitative measurement of nocturnal hypokinesia of Parkinson's disease patients compares with their spouses by using multisite accelerometers for 1 night at their home.
- Trial name
- PD (NCT02352727)
- Where
- Thailand
- Volunteers
- 28 people
- Sponsor
- Chulalongkorn University
Parkinson Disease
A Study to Analyze Symptoms Prevalent in Early PD (Dysphonia, Tremor)
This is a web-based study that involves monitoring hallmark symptoms of Parkinson's Disease (PD), specifically dysphonia and tremor, using smartphone sensor data.
- Trial name
- NCT04288804
- Testing
- Smartphone microphone sensor, Smartphone accelerometer sensor
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Goalspal LLC
Parkinson´s Disease
The Effect of High-Volume Walking With Visual Cues (VC) in Parkinson´s Disease (PD)
People with disease (PD) tend to walk with short steps, decreased velocity, and increased stride time variability. Short steps and increased variability are related to greater fall risk.
- Trial name
- NCT01391741
- Testing
- Visual Cues, Walking without visual cues
- Where
- Iceland
- Volunteers
- 26 people
- Sponsor
- University of Iceland
Parkinson's Disease
The Long Term Impact of Initiating Pramipexole Versus Levodopa in Early Parkinson's Disease (CALM-PD Cohort Study)
To determine the long-term consequences (8 years) of initiating patients with Parkinson's disease on either pramipexole or levodopa.
- Trial name
- CALM-PD Cohort (NCT00804479)
- Testing
- No intervention.
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- University of Rochester
Parkinson Disease (PD)
Different Frequency Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease
This clinical trial will evaluate the efficacy of accelerated Temporal Interference Stimulation (TIS) as a therapeutic intervention for individuals diagnosed with Parkinson's disease.
- Trial name
- NCT07721688
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ke Dong, MD