Clinical trials: Pathological Processes
Frailty, Exercise
Effects of Acupunch Exercises on the Frail Older Adults in Long-Term Care Facilities
Frailty is a complex elderly problem and a precursor of functional degradation in elder adults. The aim of this study will to test the effects of acupunch exercises on the frail older adults in long-term care facilities.
- Trial name
- NCT04481438
- Testing
- Acupunch Exercises
- Where
- 10 sites in Taiwan
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Gonorrhea Female, Chlamydia Females
The Integrated Female Sexually Transmitted Infection Testing for HIV Epidemic Control Through PrEP (IN-STEP) Study
Globally, new HIV infections are concentrated in eastern and southern Africa where the infections are largely acquired by women outside of known key populations.
- Conditions
- Gonorrhea Female, Chlamydia Females, Syphilis Female, Trichomonas Vaginalis
- Trial name
- IN-STEP (NCT06743204)
- Testing
- Self-Reported Risk Screening for PrEP and Diagnostic STI testing, Self-reported risk screening for PrEP and syndromic management for STIs
- Where
- Uganda
- Volunteers
- 5,560 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Clinical Infection, Microbial Colonization
Effect of Gut Microbiota and Fecal Inflammatory Marker on Childhood Gastroenteritis
Childhood gastroenteritis establishes gastrointestinal disease and increase the economic burden, and the pediatric population is especially vulnerable to these gastrointestinal infections.
- Conditions
- Clinical Infection, Microbial Colonization, Gastroenteritis, Inflammatory Response
- Trial name
- NCT03856138
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Rheumatoid Purpura, Pediatric ALL
Validation of the IgA1 Detection Method With Gradient Glycosylation by Mass Spectrometry as a Potential Marker of Renal Involvement in Pediatric Rheumatoid Purpura
In this ancillary study on the FoxTreg cohort, the study investigators will select variables to input and thus develop two models (Linear Discriminant Analysis and Decision Tree).
- Trial name
- FOXIGA-2020 (NCT04655378)
- Testing
- Mass Sepctrometry
- Where
- 2 sites in France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Resuscitation, Shock
Pediatric Fast Fluid Trial 2
The purpose of this study is to determine which of two commonly used methods of manual pediatric fluid resuscitation (The "Push-Pull Technique" vs.
- Conditions
- Resuscitation, Shock, Fluid Therapy, Pediatrics
- Trial name
- PFFT2 (NCT01774214)
- Testing
- Push-Pull technique, Disconnect-Reconnect Technique
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster Children's Hospital
Anal Fissure, Microbial Colonization
Microbiota in Chronic Anal Fissure and Its Association With Prognosis
In this study, we will try to answer the following questions: 1. What are the salient features of the microbiota in chronic anal fissure? 2. Are these features associated with prognosis and response to therapy? 3.
- Trial name
- NCT05405634
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lasse Krogsbøll
Alzheimer's Disease, Hippocampus
Using Neuroimaging to Early Diagnose Alzheimer's Disease Through Hippocampal Atrophy Assessment
This study aims to better understand Alzheimer's disease by looking at brain scans, specifically MRI images, to detect early signs of brain changes linked to the disease.
- Conditions
- Alzheimer's Disease, Hippocampus, Brain Atrophy, Magnetic Resonance Imaging
- Trial name
- NCT06965816
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Denis
Dental Plaque (Diagnosis), Deep Learning
Microbial Dental Plaque Analysis in Young Permanent Teeth Using Deep Learning
Background: Dental plaque contributes to a number of common oral conditions such as caries, gingivitis, and periodontitis. As a result, detection and management of plaque is of great importance for the oral health of individuals.
- Trial name
- NCT06603233
- Testing
- The Difference Between The AI Model and Dentists Group, Deep Learning Models
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Infant Malnutrition
The Mazira Project: An Evaluation of Eggs During Complementary Feeding in Rural Malawi
The Mazira Project is a study of the effect of egg consumption on growth, development and gut health of infants in Malawi. The study randomly assigns infants to receive one egg per day over six months or to receive an equivalent…
- Trial name
- NCT03385252
- Testing
- Eggs, Visits
- Where
- Malawi
- Volunteers
- 662 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Pain, Postoperative
Analgesic Effect of Three-point Transversus Abdominis Plane Block Compared With Continuous Epidural Infusion for Post-laparoscopic Nephrectomy
This study aimed to compare the efficacy three-point Transversus Abdominis Plane (TAP) blocks with continuous epidural infusion for alleviating pain post-laparoscopic nephrectomy
- Trial name
- NCT03154463
- Testing
- TAP Blocks, continuous epidural infusion
- Where
- Indonesia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Chronic Post Operative Pain
Prevalence and Risk Factors for Postsurgical Pain After the Open Reduction and Internal Fixation of Lower Limbs.
The objective of this study is to specify the demographic and medical factors that most likely constitute a risk of developing CPSP in the patients with lower limb.
- Trial name
- NCT06136663
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Microbial Colonization
Vaginal Microbiota, and STI/HIV Risk Among Adolescent Girls and Young Women
The investigators are doing a study on the bacteria that normally live in the vagina and what effect, if any, Depo-Provera has on the bacteria.
- Trial name
- AIMS (NCT03196492)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Neonate, Asphyxia
Multimodal Analysis of Early Biomarkers of the Impacts of Perinatal Asphyxia
Current diagnostic methods rely primarily on clinical symptoms, supplemented by brain imaging and physiological tests. However, these signs of injury only become apparent once significant damage has occurred, thus delaying…
- Conditions
- Neonate, Asphyxia, EEG, Eye Tracking
- Trial name
- Neurobiom (NCT07702500)
- Testing
- EEG
- Where
- France
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pancreatic Exocrine Insufficiency
The Development of a Metabolomic Test to Diagnose and Quantify Pancreatic Exocrine Insufficiency (The DETECTION Study)
DETECTION. The development of a metabolomic test to diagnose and quantify pancreatic exocrine insufficiency.
- Trial name
- DETECTION (NCT05980221)
- Testing
- Metabolomics, 13C MTGT
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Liver Fibrosis Progression in Chronic Liver Disease
LIVER FIBROSIS PREVALENCE IN FRANCE
"Mortality related to complications of cirrhosis, (hemorrhage, hepatic insufficiency and primary liver cancer) is 15,000 per year in France.
- Trial name
- FIBROFRANCE (NCT01927133)
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Retention
Effect of Piezoelectric Alveolar Decortication on Post-Orthodontic Lower Incisors Stability: A Randomized Clinical Trial
To assess the effect of piezocision on post-orthodontic lower anterior teeth stability as compared to fiberotomy and conventional Hawley retainers.
- Trial name
- NCT05014308
- Testing
- Piezoelectric Alveolar Decortication, fibrotomy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Surgical Site Infection
Skin Staples vs Polypropylene in Elective Laparotomy
Surgical site infection (SSI) is one of the most common postoperative complications following elective laparotomy and contributes significantly to patient morbidity, prolonged hospital stay, and increased healthcare costs.
- Trial name
- NCT07781878
- Testing
- Skin staples, Polypropylene skin suture
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Feeding; Difficult, Newborn, Growth Failure
Prophylactic Probiotics to Extremely Low Birth Weight Prematures
Mortality and incidence of severe complications is still high among extremely premature infants. Common causes of severe complications in this population are poor nutrition, necrotizing enterocolitis, and severe infections.
- Conditions
- Feeding; Difficult, Newborn, Growth Failure, Necrotizing Enterocolitis, Sepsis
- Trial name
- PROPEL (NCT01603368)
- Testing
- Lactobacillus reuteri
- Where
- 2 sites in Sweden
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Ostergotland County Council, Sweden
Postoperative Pain
Can the Different Instruments Used ın Root Canal Treatment Have an Effect on Postoperative Pain?
Root canal treatment is a treatment method in which the pulp is irreversibly infected due to caries or trauma or when the pulp loses its vitality.
- Trial name
- NCT05927025
- Testing
- Hand K-files
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Human Papillomavirus Infection
Video-Assisted Counseling for HPV Vaccination
Video-assisted counseling has been shown to improve consistency of counseling regarding a wide variety of health-care related issues.
- Trial name
- NCT03510091
- Testing
- Counseling
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Le Bonheur Children's Hospital
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