Clinical trials: Pathophysiology
Dry Eye Disease, Meibomian Gland Disease
Treating Meibomian Gland Disease in a Pediatric Population
Dry Eye Disease (DED) is commonly encountered among eye care professionals. DED is a disease of the tears and ocular surface that is multi-factorial resulting in a wide range of symptoms and signs with potentially damaging…
- Trial name
- LLLT in Peds (NCT07229001)
- Testing
- Low level light treatment, warm compress and artificial tear
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Illinois College of Optometry
Cleft Lip and Cleft Palate, Cleft Lip Palate
Early Intervention in Infants With Unrepaired Cleft Palate: Language, Palatal Function, and Articulation.
The goal of this clinical trial is to learn if teaching speech skills to infants with cleft palates, prior to palate repair, will help them to develop speech and language skills.
- Conditions
- Cleft Lip and Cleft Palate, Cleft Lip Palate, Cleft Lip and/or Palate, Cleft Palate
- Trial name
- NCT07219901
- Testing
- Early intervention for language, articulation and palatal function skills
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Old Dominion University
Mild Cognitive Impairment
Shanghai Mild Cognitive Impairment Cohort Study
This study was planned 1) to identify individuals with Mild Cognitive Impairment (MCI) who convert to Alzheimer's Disease (AD), and 2) to explore factors associated with the conversion.
- Trial name
- NCT01552265
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Eyelid Diseases
Evaluation of Satisfaction Regarding Patient's Management of Ocular Surface Diseases
Multicentric study, open label, uncontrolled phase IV in 30 patients with meibomian glands dysfunction . Its objective is to Collect information from patients and ophthalmologists specialized in ocular surface and eyelids to…
- Trial name
- ESPOIR (NCT01091311)
- Testing
- Blephasteam
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Laboratoires Thea
Congenital Heart Disease, Executive Dysfunction
Learning by Heart: The Effectiveness of an EF Training Program for Pre-schoolers With Critical CHD
Advances in prenatal and neonatal care have improved outcomes in children with critical congenital heart disease (CCHD). With the increase in survival, neurocognitive problems such as executive functioning (EF) impairments have…
- Conditions
- Congenital Heart Disease, Executive Dysfunction, Attention Disorder
- Trial name
- LbH (NCT06267430)
- Testing
- Kleuter Extra training program
- Where
- 3 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Erasmus Medical Center
Ataxia Telangiectasia
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside
Study design: Single arm open-label clinical trial in ataxia-telangiectasia to test the effects of nicotinamide riboside on ataxia scales, immune function, and neurofilament light chain.
- Trial name
- ATNAD (NCT06324877)
- Testing
- Nicotinamide riboside
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- The University of Queensland
Cognitive Impairment, Child Autism
Exercise and Cognition in Children With ASD
Physical exercise is widely reported to be beneficial to executive functions (EFs) in children with autism spectrum disorder (ASD).
- Trial name
- NCT05503459
- Testing
- Bicycle learning, Stationary cycling
- Where
- Hong Kong
- Volunteers
- 82 people
- Sponsor
- Education University of Hong Kong
Drug Hypersensitivity
Management of Drug Hypersensitivity in Children
The aim of this study is (1) to assess the incidence of suspected drug allergies in a pediatric hospital and the proportion in which these reactions are confirmed to be allergic; (2) to evaluate the diagnostic values of the…
- Trial name
- DHC (NCT02031120)
- Where
- Switzerland
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Adolescent Mental Health, Psychosocial Adaptation
Trauma-Informed School Intervention for Adolescent Mental Health and Self-Injury Prevention in China
This study evaluated a school-based psychosocial adaptive capacity enhancement program for Chinese adolescents. The program was developed to support students who may have experienced childhood household dysfunction or other…
- Conditions
- Adolescent Mental Health, Psychosocial Adaptation, Childhood Household Dysfunction
- Trial name
- TISI-China (NCT07583524)
- Testing
- School-Based Psychosocial Adaptive Capacity Enhancement Program
- Where
- China
- Volunteers
- 5,787 people, healthy volunteers welcome
- Sponsor
- WU Han
Stunting
Child Health, Agriculture and Integrated Nutrition
CHAIN is an open-label, individually randomized trial of improved infant and young child feeding (IYCF) versus "IYCF-plus" among 192 infants enrolled between 5-6 months of age in Shurugwi district, rural Zimbabwe.
- Trial name
- CHAIN (NCT04874688)
- Testing
- Small-quantity lipid-based nutrient supplement, Provitamin A biofortified maize, NUA-45 biofortified sugar beans
- Where
- Zimbabwe
- Volunteers
- 192 people
- Sponsor
- Queen Mary University of London
Executive Dysfunction, Motor Activity
The Role of Brain-derived Neurotropic Factor in the Relationship Between Executive Function and Physical Training
This doctoral thesis has the aim to identify the role of Brain-derived neurotropic factor in the relationship between physical fitness/activity and executive functions in typically developing children and children with Autism…
- Conditions
- Executive Dysfunction, Motor Activity, Child
- Trial name
- NCT02503579
- Testing
- physical training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Ghent
Low Grade Gliomas, Craniopharyngioma
SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors
Brain tumours are the commonest solid tumours in children and the second most common neoplasms overall in this patient population. Radiotherapy plays an important part in the management in a majority of these tumours.
- Conditions
- Low Grade Gliomas, Craniopharyngioma, Ependymomas, Meningiomas
- Trial name
- SCRT (NCT00517959)
- Testing
- Stereotactic Conformal radiotherapy, Conventional radiotherapy
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Hospital
Congenital Cataract, Aphakic or Pseudophakic Glaucoma
Mechanism of Aphakic and Pseudophakic Glaucoma in Pediatric Patients
In cell cultures, lens epithelial cells and trabecular meshwork cells will be exposed to aqueous humor from pediatric eyes undergoing cataract removal surgery.
- Trial name
- NCT01136473
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Carmel Medical Center
Pancreatitis, Chronic
Surgical Outcome and Differences on Histopathology in Patients With Alcoholic & Non Alcoholic Chronic Pancreatitis
Numerous treatment modalities have been proposed to treat pain in alcoholic and non-alcoholic chronic pancreatitis such as analgesic medication, inhibition of gastric acid production, enzyme substitution, somatostatin analogues…
- Trial name
- NCT02048267
- Testing
- Frey's procedure/Pylorus preserving pancreatoduodenectomy
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Maturity Onset Diabetes of the Young
Liraglutide Treatment in Patients With Maturity-onset Diabetes of the Young (MODY)
The reason for this research study is to better understand the use of liraglutide, a commonly prescribed Type 2 diabetes medication, in patients with a diagnosis of maturity-onset diabetes of the young (MODY).
- Trial name
- NCT07029009
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mansa
Gastrointestinal Complications, Prostate Cancer
RADICALS - Radiotherapy and Androgen Deprivation In Combination After Local Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells.
- Conditions
- Gastrointestinal Complications, Prostate Cancer, Sexual Dysfunction, Urinary Complications
- Trial name
- NCT00541047
- Testing
- bicalutamide, goserelin acetate, leuprolide acetate
- Where
- 58 sites in Canada, United Kingdom
- Volunteers
- 4,236 people
- Sponsor
- University College, London
Urinary Tract Infections, Malnutrition
Effect of Hygiene and Menstrual Hygiene Interventions on Learning and Psychosocial Wellbeing in Madagascar
A previous study in schools in rural Madagascar found that a bundle of hygiene-focused interventions substantially improved girls' learning outcomes.
- Conditions
- Urinary Tract Infections, Malnutrition, Inflammation, Stress
- Trial name
- KILONGA2 (NCT07702916)
- Testing
- Peer leadership/sensitization + sanitary pads, School infrastructure
- Where
- Madagascar
- Volunteers
- 3,080 people, healthy volunteers welcome
- Sponsor
- University of California Santa Cruz
Mild Cognitive Impairment
An Observational Study for Analysis of Mortality in Participants Who Participated in Previous 3 Studies of Galantamine
The purpose of the study is to collect data of patients who were randomized (assignment of study medication by chance) and treated in 3 previous studies of galantamine (CR003145, CR002014 and CR005947) for the treatment of mild…
- Trial name
- NCT00297414
- Testing
- No intervention
- Where
- 144 sites in United States, Argentina and 14 more
- Volunteers
- 1,083 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cerebral Palsy, Congenital
Effects of Hippotherapy in Children With Cerebral Palsy
Cerebral palsy is a group of permanent disorders affecting movement and posture due to non-progressive disturbances in the developing brain.
- Trial name
- NCT07739680
- Testing
- Hippotherapy Program, Special Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Fenerbahce University
Posterior Fossa Tumors, Pediatric Tumor of Brain
Predicting Cognitive Dysfunction After Pediatric Posterior Fossa Tumor Surgery
The goal of this observational study is to develop and validate a clinical prediction model to identify risk factors for long-term cognitive dysfunction in children (ages 0-18 years) who have undergone surgical resection of a…
- Trial name
- NCT07350382
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 600 people
- Sponsor
- West China Hospital
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