Clinical trials: Patient-controlled Sedation
Enhanced Recovery After Surgery in a Pediatric Population
Dex +/- Caffeine Sedation in a Post-MRI Recovery in a Pediatric Population
Dexmedetomidine (Dex), a selective α2-adrenergic receptor agonist, is the most used sedative for procedural sedation in children and in pediatric Intensive Care Unit (PICU) because it is associated with less respiratory…
- Trial name
- NCT06538584
- Testing
- Caffeine citrate 15mg/kg, 0.9% Sodium Citrate
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Respiratory Failure
Cycling of Sedative Infusions in Critically Ill Pediatric Patients
The purpose of this study is to determine if the reduction of the total amount of sedative critically pediatric ill patients receive in the PICU will achieve a significant decrease in mechanical ventilation days and a decrease in…
- Trial name
- NCT01333059
- Testing
- Midazolam, Normal saline, Fentanyl
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Javier Gelvez, MD
Preoperative Anxiety Experienced by the Pediatric Patient, Preoperative Anxiety
Comparing Two Doses of Midazolam With Added Dexmedetomidine for Kids Before Surgery
The goal of this randomized controlled trial is to investigate if adding intranasal dexmedetomidine to two different doses of intranasal midazolam provides effective sedation with fewer side effects in pediatric patients aged 1…
- Trial name
- NCT06979791
- Testing
- Dexmedetomidine + Midazolam 0.4 mg/kg, Dexmedetomidine + Midazolam 0.2 mg/kg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Abdominal Pain
Carbon Dioxide Insufflation Versus Conventional Air Insufflation
The safety and effectiveness of esophagogastroduodenoscopy and colonoscopy in the detection of gastrointestinal-tract pathology in children has been established during the last three decades.
- Trial name
- NCT02790359
- Testing
- Air, Carbon dioxide
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Medical College of Wisconsin
Sedation
Intranasal Ketamine Versus Intramuscular Ketamine for Procedural Sedation in Pediatric Patients
The purpose of this study is to determine if intranasal ketamine is equally as effective and safe as intramuscular ketamine for procedural sedation in pediatric patients.
- Trial name
- NCT01170247
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Mental Retardation
Accurate Controlled Dental Sedation
The aim of this study is to evaluate benefits of the method of dental sedation using Target controlled infusion (TCI) combined with Bispectral index (BIS) monitoring in patients with Mental Retardation and challenging behavior.
- Trial name
- ACDS (NCT00963898)
- Testing
- Target controlled infusion(TCI), Bispectral index(BIS)
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Okayama University
Sedated ICU Patients
IMPROVE Critical Care Study (Pilot)
The Pilot Clinical Investigation planned is a prospective, unblinded randomized pilot trial comparing sedation management using a protocol based on responsiveness with standard sedation management.
- Trial name
- NCT01361230
- Testing
- "Sedation Trial Monitor" is the name of the device used.
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Ketamine, Fentanyl
Esketamine Sedation and Fentanyl Sedation in Pediatric Dental Patients
Since the 1970s, ketamine has been used in clinical anesthesia treatment. Compared with ketamine, esketamine has a higher clearance rate, so it has a shorter recovery time after anesthesia.
- Conditions
- Ketamine, Fentanyl, Sedation Complication
- Trial name
- NCT04597320
- Testing
- Fentanyl, Esketamine, Midazolam
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Peking University
Failed Conscious Sedation During Procedure
The Efficacy and the Safety of Dexmedetomidine Sedation on the Pediatric Intensive Unit(PICU) Patients.
To observe the efficacy and safety of dexmedetomidine sedation on the patients admitted to the pediatric intensive care unit after surgery.
- Trial name
- NCT02296073
- Testing
- Midazolam, Dexmedetomidine, Fentanyl
- Volunteers
- 120 people
- Sponsor
- Anhui Provincial Children's Hospital
Sedation
Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old
This is a study to compare safety and efficacy of inhaled isoflurane delivered by the AnaConDa-S (Anaesthetic Conserving Device (ACD)) versus intravenous midazolam for sedation in mechanically ventilated children admitted to an…
- Trial name
- IsoCOMFORT (NCT04684238)
- Testing
- Midazolam, Isoflurane
- Where
- 24 sites in France, Germany and 3 more
- Volunteers
- 94 people
- Sponsor
- Sedana Medical
Intensive Care Units, Pediatric, Anesthetics, Inhalation
Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents
The goal of a pilot study is to test a study plan to see if it is appropriate for a larger study. This study plan is looking at whether the use of inhaled sedatives (medications that help people be calm and sleep) can reduce…
- Conditions
- Intensive Care Units, Pediatric, Anesthetics, Inhalation, Mechanically Ventilated, Critically Ill Children
- Trial name
- ABOVE (NCT05867472)
- Testing
- Isoflurane Inhalant Product
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Dental Anxiety in Children, Child Behaviour
Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide Monotherapy
The rationale of this trial is to evaluate whether combining intranasal atomized midazolam with nitrous oxide offers better behavior management leading to successful treatment completion in comparison with using nitrous oxide…
- Trial name
- NCT07876024
- Testing
- Midazolam (Intranasal), Nitrous oxide/oxygen inhalation sedation alone
- Where
- Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Postoperative Sedation, Abdominal Surgery
Evaluation of the Effect of Appropriate Sedation for Patients After Abdominal Surgeries : A Prospective Randomised Controlled Study
To evaluate the efficacy and safety of appropriate postoperative sedation with dexmedetomidine for patients after abdominal surgeries.Prospective randomised controlled study was conducted among patients after abdominal surgeries…
- Trial name
- NCT02670954
- Testing
- Dexmedetomidine, tramadol and flurbiprofen, tramadol and flurbiprofen
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Chinese Medical Association
Sedation in Intensive Care
Efficacy, Safety and Pharmacokinetic Study of Intravenous Clonidine Versus Midazolam for Sedation in Paediatric Patients
Closed1 aims to compare the efficacy, safety and pharmacokinetics of clonidine (hydrochloride) to midazolam in the sedation of ventilated children and adolescents (0-18 years) admitted to a paediatric intensive care unit (PICU)…
- Trial name
- CloSed1 (NCT02509273)
- Testing
- Clonidine, Midazolam
- Where
- 10 sites in Czechia, Estonia and 5 more
- Volunteers
- 28 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Behavior Management
Effect of Audio-analgesia Using Binaural Beats and Instrumental Music on the Behaviour of Minimally Sedated Pediatric Patients
The aim of this study is to evaluate the effect of audio analgesia (using binaural beats and instrumental music) in conjunction with a minimal dose of intranasal aerosolized midazolam on acquiring satisfactory patient cooperation.
- Trial name
- NCT07770321
- Testing
- Audio analgesia, 0.3 mg/kg midazolam, 0.5 mg/kg midazolam
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Rania Ahmedien
Nurse's Role, Bispectral Index
Nurse-Led BIS-Guided Sedation Protocol in Pediatric Intensive Care
Pediatric intensive care sedation is traditionally based on subjective clinical scales. Bispectral Index (BIS) monitoring provides an objective EEG-based assessment of sedation depth.
- Conditions
- Nurse's Role, Bispectral Index, Pediatric Sedation
- Trial name
- NCT07252024
- Testing
- BIS-Guided Sedation Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Deep Sedation, Dexmedetomidine
Intranasal Dexmedetomidine for Deep-sedated Pediatric Dental Patients
It is important to choose an appropriate analgesia/sedation technique in pediatric dental treatment. Premedication combined with intravenous anesthesia is often used in deep sedation technique for pediatric dental treatment and…
- Trial name
- NCT04509414
- Testing
- Dexmedetomidine, Midazolam
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University
Pneumonia, Respiration Disorders
Continuous Sedation vs Daily Sedation Interruption in Ventilated Children
Sedation is essential for mechanically ventilated pediatric patients to ensure comfort, ventilator synchrony, and prevention of self-extubation.
- Trial name
- NCT07438834
- Testing
- Continuous Sedation Infusion (CSI), Daily Sedation Interruption (DSI)
- Volunteers
- 96 people
- Sponsor
- University of Health Sciences Lahore
Critical Illness
Lorazepam Sedation for Critically Ill Children
This clinical trial is being performed under the Best Pharmaceuticals for Children Act, signed into law in 2002 in order to improve pediatric labeling for off-patent drugs.
- Trial name
- NCT00109395
- Testing
- Lorazepam, Midazolam, Lorazepam CI
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- The Emmes Company, LLC
Anesthesia Outcomes, Anesthesia Complication
Does Style of Pre-sedation Instructions Improve Patient Outcomes in Ambulatory Anesthesia for Oral and Maxillofacial Surgery?
This randomized controlled trial aims to evaluate the impact of a brief guided visualization exercise on anesthesia-related outcomes in oral and maxillofacial surgery in patients scheduled for ambulatory anesthesia in the oral…
- Conditions
- Anesthesia Outcomes, Anesthesia Complication, Anesthesia and Procedure Related Time Intervals, Anesthesia Recovery Period
- Trial name
- NCT06768021
- Testing
- Guided visualization and standardized pre-sedation instructions, Standardized pre-sedation instructions only
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Alameda Health System