Clinical trials: Pediatric
Advanced Solid Tumors, Metastatic Pancreatic Cancer
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Background: Metastasis is the spread of cancer from one organ to a nonadjacent organ. It causes 90% of cancer deaths. No treatment specifically prevents or reduces metastasis. Researchers hope a new drug can help.
- Conditions
- Advanced Solid Tumors, Metastatic Pancreatic Cancer, Pediatric Solid Tumor, Advanced Breast Cancer
- Trial name
- NCT04222413
- Testing
- Metarrestin
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- National Cancer Institute (NCI)
Pediatric Obesity, Childhood Obesity
Impact of a Playful Family Education Strategy With ICT on Childhood Obesity Prevention
The goal of this non-randomized quasi experimental clinical controlled trial is to evaluate the impact of a playful family education strategy reinforced by the use of communication technologies in childhood obesity.
- Conditions
- Pediatric Obesity, Childhood Obesity, Childhood Overweight
- Trial name
- NCT06486493
- Testing
- Playful Family Education Strategy
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Instituto Mexicano del Seguro Social
Pediatric Obesity
Effects of Digital Health Interventions on the Motivation, Health-related Behavior and Mental Health of Middle School Students
The goal of this cluster-randomized clinical trial is to learn whether digital interventions, especially a motivational interviewing (MI) chatbot can improve adolescents' physical activity motivation and behavior, as well as…
- Trial name
- NCT06547567
- Testing
- MI chatbot Intervention, General-counseling chatbot intervention, Graphic-text intervention
- Where
- China
- Volunteers
- 705 people, healthy volunteers welcome
- Sponsor
- Peking University
Pediatric Dentistry, Premature Loss of Primary Molars
Evaluation of Polyetheretherketone and Monolithic Zirconia Versus Conventional Metal Band and Loop Space Maintainers in Children: A Randomized Split-Mouth Clinical Trial
Compare two tooth-colored CAD/CAM band and loop space maintainers, PEEK and monolithic zirconia (BruxZir), each against a conventional stainless-steel band and loop in children with premature loss of mandibular primary first…
- Conditions
- Pediatric Dentistry, Premature Loss of Primary Molars, Space Maintainer
- Trial name
- NCT06558968
- Testing
- PEEK band and loop space maintainer, BruxZir band and loop space maintainer, conventional stainless-steel band and loop space maintainer
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Binge Eating Disorder, Binge Eating
Effectiveness of a 10-week Multicomponent Intervention Combined With Parent Education on Binge Eating Behavior in Children and Adolescents
The main purpose is to investigate the effectiveness of a 10-week multicomponent camp intervention to reduce BE behavior in children and adolescents and explore in a randomized controlled setting if a parent-based…
- Conditions
- Binge Eating Disorder, Binge Eating, Loss of Control Eating, Overweight , Obesity
- Trial name
- STOB (NCT07301541)
- Testing
- A 10-week multicomponent camp intervention for children, A BED intervention for parents
- Where
- 2 sites in Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Very Rare Tumors, Very Rare Cancers
NCI Childhood Cancer Data Initiative (CCDI) Led Pediatric, Adolescent, and Young Adult Rare Cancer Registry for Very Rare Solid Tumors
Background: All childhood cancers are rare, but some are called very rare. Very rare cancers are diagnosed in 2 or fewer out of 1 million people each year.
- Conditions
- Very Rare Tumors, Very Rare Cancers, Other Solid Tumors, Solid Tumor
- Trial name
- NCT07489378
- Testing
- Natural history study of individuals with very rare tumors
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- National Cancer Institute (NCI)
Pediatric Chalazia
Omega-3 Supplementation vs Demodex vs Eyelid Cleanser for Pediatric Chalazia
Participants enrolled into the study will be prescribed twice daily warm compresses for 8 weeks and randomly allocated (1:1:1) to receive either 1) Oral omega-3 supplementation and standard eyelid cleanser, 2) Anti-Demodex eyelid…
- Trial name
- CH01 (NCT07496515)
- Testing
- Omega-3 supplement, Warm compress, Standard eyelid cleanser
- Volunteers
- 168 people
- Sponsor
- Jaeb Center for Health Research
Pediatric Venipuncture
Therapeutic Holding Versus Traditional Restraint During Pediatric Venipuncture
This study will compare therapeutic holding with traditional restraint during blood-draw venipuncture in children aged 3 to 6 years.
- Trial name
- NCT07906210
- Testing
- Therapeutic Holding, Traditional Restraint
- Volunteers
- 64 people
- Sponsor
- University of Baghdad
Emergence Delirium in Pediatric Anesthesia
Predicting the Risk of Pediatric Emergence Delirium
The incidence of PED ranges from 2% to 50%, with a peak occurring 5-15 minutes after emergence from anesthesia. PED seriously endangers pediatric patient safety and impairs family experience.
- Trial name
- NCT07906977
- Testing
- Assessment of Pediatric Emergence Delirium
- Where
- China
- Volunteers
- 470 people
- Sponsor
- General Hospital of Ningxia Medical University
Solid Tumors, Brain Tumors
NK White Blood Cells and Interleukin in Children and Young Adults With Advanced Solid Tumors
BACKGROUND: Despite progress, some children and young adults with solid tumors still experience poor survival. Activated NK cells potently kill autologous pediatric solid tumors, and clinical grade procedures are available to…
- Conditions
- Solid Tumors, Brain Tumors, Sarcoma, Pediatric Cancers
- Trial name
- NCT01875601
- Testing
- Recombinant human interleukin-15 (rhIL-15), NK Cell Infusion
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Malignant Solid Tumors, Other Neoplasms Solid Tumors
Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors
Background: Approximately 150 cases of cancer per one million per year are considered rare cancers. While all tumors originate from genetic changes, a small percentage of these tumors are familial.
- Conditions
- Malignant Solid Tumors, Other Neoplasms Solid Tumors, Pediatric Solid Tumor, Refractory Solid Tumors
- Trial name
- NCT03739827
- Where
- 3 sites in United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Reproductive Physiological Processes, Pediatrics
Reproductive Axis Maturation in the Early Post-Menarchal Years
Background: Most adult women with irregular periods of unknown cause report symptoms dating back to early adolescence. This study aims to learn how girls' periods change in the 2 years after their first period.
- Conditions
- Reproductive Physiological Processes, Pediatrics, Adolescent Health, Adolescent Development
- Trial name
- NCT03986021
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Pediatric Obstructive Sleep Apnea
Development of a Wearable Point of Care Monitoring Device for Pediatric Obstructive Sleep Apnea
Background: Obstructive sleep apnea (OSA) occurs when the blockage of the airway causes a person to stop breathing involuntarily for 10 seconds or more throughout the night during sleep.
- Trial name
- NCT05052216
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pediatric Cancer, Cognitive Dysfunction
Engaging Parents in Neuropsychological Rehabilitation for Childhood Cancer Survivors: The ImPACT Program - A Pilot Study
The aim of the present pilot study is to evaluate the feasibility, acceptability, and preliminary efficacy of a novel, context-sensitive neuropsychological rehabilitation intervention for childhood cancer survivors and their…
- Trial name
- NCT05483166
- Testing
- ImPACT
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Aarhus University Hospital
Brain Tumor, Pediatric
Neurocognitive and Psychosocial Outcomes Among Pediatric Brain Tumor
This will be the first in-depth study to evaluate pretreatment and 12 months post-treatment, neurocognitive and psychological outcomes of children with brain tumor in Pakistan.
- Trial name
- PBT (NCT05709522)
- Testing
- Neurocognitive tools
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Aga Khan University
Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure
Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement
Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and…
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure, Acute Respiratory Distress Syndrome
- Trial name
- DECFVTTPM (NCT06051292)
- Testing
- Fast method, Conventional method
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
LGCMN, Large and Giant Congenital Melanocytic Nevi
Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young Adults
Background: Large and giant congenital melanocytic nevi (LGCMN) are dark birthmarks (moles). They can grow to 8 inches or more across.
- Conditions
- LGCMN, Large and Giant Congenital Melanocytic Nevi, NF1, Solid Tumor
- Trial name
- NCT07891286
- Testing
- Mirdametinib
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Dental Restorations in Children, Pediatric Dentistry
3D-Printed Resin Crowns Versus Bioflx Crowns in Primary Molars
This randomized comparative clinical trial will evaluate and compare the clinical performance of preformed three-dimensional (3D)-printed resin crowns and Bioflx crowns in children with pulp-treated primary molars requiring full…
- Trial name
- NCT07902570
- Testing
- Preformed 3D-Printed Resin Crown, Bioflx Crown
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Acute Lymphoblastic Leukemia, Pediatric, Pediatric Cancer
Biology and Benefits of Music Play and Stories for Kids/Parents During ALL Treatment
Music therapy has become a standard palliative care service in many pediatric and adult hospitals; however, a majority of music therapy research has focused on the use of music to improve psychosocial dimensions of health…
- Trial name
- NCT04400071
- Testing
- Active Music Engagement, Audio Storybooks
- Where
- 4 sites in United States
- Volunteers
- 192 people
- Sponsor
- Indiana University