Clinical trials: Pediatric Cancers
Iron Overload
Iron Overload in Pediatric Oncology Patients
The purpose of this study is to evaluate for iron overload in pediatric oncology and transplant patients who have completed their treatment between one to ten years ago.
- Trial name
- NCT01034072
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Diabetes Mellitus Risk
Hyperglycaemia In Childhood Hematologic Malignancies
BACKGROUND/AIM: Secondary forms of diabetes are often understudied and underdiagnosed in children and adolescents with cancer. The objectives of this cohort study were to study the incidence and risk factors for hyperglycaemia in…
- Trial name
- DIAB-ONCO (NCT05525364)
- Where
- Belgium
- Volunteers
- 303 people
- Sponsor
- Université Catholique de Louvain
Acute Myeloid Leukemia, Stem Cell Leukemia
Nalbuphine Versus Morphine for Mucositis Pain in Pediatric Cancer Patients
Evaluation of safety and efficacy of Nalbuphine versus Morphine patient controlled analgesia (PCA) for mucositis pain in pediatric cancer patients
- Trial name
- PCA (NCT03825887)
- Testing
- Nalbuphine, Morphine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Basal Tryptasemia
Serum Basal Tryptase Levels in Healthy Children
The National REference Center for MASTocytosis (CEREMAST), located at the Necker-Enfants Malades Hospital, is particularly interested in two groups of rare diseases whose common point is excessive activation of mast cells…
- Trial name
- KID-Tryp (NCT05323188)
- Testing
- Tryptase dosage
- Where
- France
- Volunteers
- 402 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer, Communication
Revealing Information Genuinely & Honestly Across Time - Communication Preferences Visit
The purpose of this research study is to obtain insights and feedback from patients and parents about a new approach to support conversations about how cancer may affect one's future life and quality of life (i.e., prognostic…
- Trial name
- NCT06993688
- Testing
- Prognostic Communication-Patient/parent, Prognostic Communication-CPC, Prognostic Communication-Oncologist
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Hematological Malignancy
A Study of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients
The purpose of the study is to evaluate the pharmacokinetics (PK), safety and tolerability of multiple doses of intravenous (IV) and oral isavuconazonium sulfate administered daily in pediatric patients.
- Trial name
- NCT03241550
- Testing
- isavuconazonium sulfate - intravenous, isavuconazonium sulfate - oral
- Where
- 16 sites in United States
- Volunteers
- 49 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Pediatric Cancer
Nurse-led Transitional Care to Improve Symptom Management in Childhood Cancer Survivors
This study aims to evaluate the feasibility and preliminary effectiveness of a nurse-facilitated interdisciplinary transitional care programme, based on the Omaha system, for Chinese childhood cancer survivors (CCSs) and their…
- Trial name
- NCT07273682
- Testing
- Counseling based on Omaha system, Usual Care
- Volunteers
- 68 people
- Sponsor
- The Hong Kong Polytechnic University
Leukemia, Myelogenous, Chronic, Leukemia, Lymphoblastic, Acute
Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies
The purpose of this study is to show that myeloablative hematopoietic progenitor cell transplantation (HPCT) continues to offer acceptable disease-free survival for select patients requiring HPCT.
- Conditions
- Leukemia, Myelogenous, Chronic, Leukemia, Lymphoblastic, Acute, Leukemia, Myelogenous, Acute, Myeloproliferative-Myelodysplastic Diseases
- Trial name
- NCT00619879
- Testing
- Myeloablative Chemotherapy Regimen for Lymphoid Malignancies or Cord Blood Unit Recipients, Myeloablative Chemotherapy Regimen for Non-Cord Blood Unit Recipients with Myeloid Malignancies, Hematopoietic Progenitor Cell Transplantation (HPCT)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Pediatric Cancer, Analgesia
Intranasal Versus Intravenous Drug in Painful Procedure for Outpatient Oncologic Participants
Pain is a vital sign that depends on personal experience involving different factors such as previous sensory and emotional experience, age, spiritual and cultural aspects, that makes it harder to evaluate, especially in young…
- Conditions
- Pediatric Cancer, Analgesia, Procedural Pain
- Trial name
- NAIVe (NCT04621110)
- Testing
- intranasal dexmedetomidine, intranasal fentanyl, intravenous ketamine (ketalar®)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Pediatric Cancer, Physical Activity
Pediatric Physical Activity for Children With Cancer
The goal of this pilot study is to test the feasibility and participant adherence (pediatric patients diagnosed with childhood cancer) to a virtual, 12-week physical activity program. The aims of this project are to: 1.
- Trial name
- PePA (NCT06012825)
- Testing
- Physical Activity
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Hawaii
Recurrent Respiratory Papillomatosis
Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis
Juvenile onset recurrent respiratory papillomatosis (JORRP) is a rare, difficult to treat, benign tumor of the pediatric airway.
- Trial name
- NCT01058317
- Testing
- Propranolol
- Sponsor
- Massachusetts Eye and Ear Infirmary
Hypertensive Patients
Pharmacometric Modeling of a Hospital Preparation
Pediatric prescribers are very often faced with a lack of suitable therapies, particularly oral ones. This represents a major public health problem and necessitates adjustments to dosage or pharmaceutical form using medications…
- Trial name
- PEDIATENS (NCT07372560)
- Testing
- Evaluation of the pharmacokinetic parameters of an oral formulation of nicardipine hydrochloride
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Rouen
Medulloblastoma, Childhood
177Lu-DTPA-Omburtamab Radioimmunotherapy for Recurrent or Refractory Medulloblastoma
Children and adolescents diagnosed with medullablastoma and with recurrent or refractory to frontline therapy will be treated with 177Lu-DTPA-omburtamab, which is a radioactive labelling of a murine monoclonal antibody targeting…
- Trial name
- NCT04167618
- Testing
- 177Lu-DTPA-omburtamab
- Where
- 10 sites in United States, Denmark and 3 more
- Volunteers
- 2 people
- Sponsor
- Y-mAbs Therapeutics
Bone Cancer
Genomic Analysis of Pediatric Bone Tumors
To determine whether gene expression analysis of primary tumor samples before and after chemotherapy are predictive of long-term survival in pediatric patients with bone sarcomas (Ewings sarcoma (ES) and Osteosarcoma(OS)).
- Trial name
- NCT01047878
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Stanford University
Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia, Refractory
Study of CD19 Allogeneic Memory T-cell Therapy for Relapsed/Refractory CD19+ Leukemia
This is a Phase I clinical study evaluating the safety and maximum tolerated dose of a novel CAR T-cell product: allogeneic memory (CD45RA- negative) T-cells expressing a CD19-specific CAR 41BBz (CD19-CAR.CD45RA- negative…
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia, Refractory, Pediatric ALL
- Trial name
- NCT04881240
- Testing
- CD19-CAR(Mem) T-cells, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- St. Jude Children's Research Hospital
Brain Tumor, Pediatric, Brainstem Glioma, Brain Tumor, Pediatric, Recurrent
Application of Palliative Treatment in Children With Brain Stem Glioma and Recurrent High-grade Tumors in the Central Nervous System With the Nanomaterial NPt-Ca
This Protocol is a pilot, clinical interventional study to selected patients between five and fourteen years of both sexes, carriers of the diagnosis of glioma brain stem and high grade recurrent in the central nervous system…
- Trial name
- NCT03250520
- Testing
- Platinum acetylacetonate (1% wt) supported by sol-gel technology functionalized titania
- Where
- Mexico
- Volunteers
- 8 people
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Chronic Illness, Hematologic Malignancy
Distracting Through Procedural Pain and Distress
Children with acute and chronic illness undergo frequent, painful, and distressing procedures. This randomized control trial was used to evaluate the effectiveness of guided imagery (GI) vs virtual reality (VR) on the procedural…
- Conditions
- Chronic Illness, Hematologic Malignancy, Bone Marrow Transplant Infection, Oncology
- Trial name
- NCT04892160
- Testing
- Guided Imagery, Virtual Reality
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- Medical College of Wisconsin
Solid, Liquid, Central Nervous System Tumors
Next Generation Sequencing of Normal Tissues Prospectively in Pediatric Oncology Patients
The development of next generation sequencing (NGS) techniques, including whole genome (WGS), exome (WES) and RNA sequencing has revolutionized the ability of investigators to query the molecular mechanisms underlying tumor…
- Trial name
- NCT02530658
- Testing
- Study Introduction Visit, Informed Consent Visit, Informed Consent Follow-Up Visit
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- St. Jude Children's Research Hospital
Postoperative Pain
Rectal Dexmedetomidine Niosomes for Postoperative Analgesia in Pediatric Cancer Patients.
Applying nanotechnology in drug delivery systems improved the bioavailability and kinetic profile of drugs in biological systems
- Trial name
- DEX-NANO (NCT05340725)
- Testing
- DEX-IV, DEX-Rectal, DEX-Nano-Rectal
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Acute Myeloid Leukemia
MRD Testing Before and After Hematopoietic Cell Transplantation for Pediatric Acute Myeloid Leukemia
This is a non-therapeutic study. Pediatric AML patients undergoing HCT with a myeloablative preparative regimen may be enrolled. Subjects can be enrolled 10-40 days prior to HCT.
- Trial name
- NCT01385787
- Where
- 38 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- Center for International Blood and Marrow Transplant Research