Clinical trials: Pediatric Cardiology
Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction
Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Function and Recovery in Children After Cardiac Surgery.
This study examines the effects of coughing exercises and incentive spirometry (IS) on lung function and recovery in children who undergo heart surgery.
- Conditions
- Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction, Postoperative Recovery After Cardiac Surgery
- Trial name
- CEXIS (NCT07405333)
- Testing
- Coughing Exercises, Incentive Spirometry, Standard Postoperative Care
- Where
- 4 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
Childhood Obesity, Physical Inactivity
The Halland Obesity Municipal Effort for Children
A retrospective study to investigate the method called The Halland Obesity Municipal Effort for children. All children participating in the intervention since the start of this specific method will be eligible for inclusion.
- Conditions
- Childhood Obesity, Physical Inactivity, Physical Activity, BMI
- Trial name
- NCT05254938
- Testing
- The Halland Obesity Municipal Effort for children
- Where
- Sweden
- Volunteers
- 141 people
- Sponsor
- Göteborg University
Rheumatoid Purpura, Pediatric ALL
Validation of the IgA1 Detection Method With Gradient Glycosylation by Mass Spectrometry as a Potential Marker of Renal Involvement in Pediatric Rheumatoid Purpura
In this ancillary study on the FoxTreg cohort, the study investigators will select variables to input and thus develop two models (Linear Discriminant Analysis and Decision Tree).
- Trial name
- FOXIGA-2020 (NCT04655378)
- Testing
- Mass Sepctrometry
- Where
- 2 sites in France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Obesity, Exercise
Structured Exercise Prescription Program in Obese Children
This controlled clinical trial aims to compare the effects of a multicomponent program that includes structured personalized exercise prescription in children with obesity with a control group that will be enrolled in a…
- Conditions
- Obesity, Exercise, Cardiovascular Risk Factor, Liver Diseases
- Trial name
- NCT03552367
- Testing
- Personalized structured exercise program, Non personalized non-structured exercise program
- Where
- Mexico
- Volunteers
- 140 people
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Ehler's Danlos Syndrome, Obstructive Sleep Apnea
Obstructive Sleep Apnoea in Children and Adolescents With Ehlers-Danlos Syndrome
Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility.
- Trial name
- NCT02712060
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Heart Failure, Left Ventricular Systolic Dysfunction
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period.
- Trial name
- NCT05714085
- Testing
- Vericiguat tablet, Vericiguat suspension
- Where
- 111 sites in United States, Belgium and 28 more
- Volunteers
- 342 people
- Sponsor
- Merck Sharp & Dohme LLC
Low Cardiac Output
Comparison of Techniques for Assessing Cardiac Output and Preload in Critically Ill Pediatric Patients
Each year in the United States more than 30,000 children are admitted to intensive care units. The majority of these children have some degree of heart instability during their stay, yet there is currently no routine way to…
- Trial name
- NCT00167440
- Where
- United States
- Sponsor
- University of Rochester
Congenital Heart Disease
Copeptin- Relevance as a Perioperative Marker in Pediatric Cardiac Surgery
This study evaluates the relevance of Copeptin in children with congenital heart disease undergoing cardiac surgery with the need of cardiopulmonary bypass. Three blood samples are taken of each patient.
- Trial name
- NCT03316508
- Where
- Austria
- Volunteers
- 81 people
- Sponsor
- Claudia Herbst
Ventricular Dysfunction, Ventricular Dysfunction, Left
Registry to Monitor Berlin Heart EXCOR® Pediatric VAD as a Bridge to Cardiac Transplantation.
The purpose of this post market surveillance is to continue monitoring the safety and effectiveness of the Berlin Heart EXCOR® Pediatric.
- Conditions
- Ventricular Dysfunction, Ventricular Dysfunction, Left, Ventricular Dysfunction, Right
- Trial name
- NCT03701997
- Testing
- EXCOR Pediatric
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Berlin Heart, Inc
Ventricular Septal Defects, Persistent Common Atrioventricular Canal
Optimal Timing for Repair of Left to Right Shunt Lesions
The purpose of this study is to determine the optimal timing for repair of left-to-right shunt lesions such as ventricular septal defects and atrioventricular canals.
- Trial name
- NCT00229827
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Healthcare of Atlanta
Single Ventricle
Effect of Tadalafil on Exercise Capacity in Pediatric Fontan Patients
This pilot study is aimed at assessing the short-term effects of Tadalafil on the hemodynamic response to exercise and exercise capacity in patients with Fontan circulation.
- Trial name
- NCT01291069
- Testing
- Tadalafil Citrate, Sugar pill
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Obesity, Childhood, Risk Factor, Cardiovascular
The Svendborg-project
The main aim of this study is to describe differences in development of health and motor performance over time in relation to type of school and other background variables.
- Conditions
- Obesity, Childhood, Risk Factor, Cardiovascular, Sports Injury, Physical Activity
- Trial name
- CHAMPS-DK (NCT03510494)
- Testing
- Augmented physical education program
- Where
- Denmark
- Volunteers
- 1,209 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Venous Thromboembolism, Deep Venous Thrombosis
Prevalence and Risk Factors of Venous Thromboembolism in Hospitalized Pediatric Patients
The issue to be studied is the prevalence of venous thromboembolism (VTE) in hospitalized pediatric patients, and to identify if there are subgroups of patients who may be at higher risk.
- Conditions
- Venous Thromboembolism, Deep Venous Thrombosis, Pediatrics
- Trial name
- pediatric DVT (NCT01140386)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Penn State University
Type 1 Diabetes, Type 2 Diabetes
ACCESS: AI for pediatriC diabetiC Eye examS Study
The purpose of this study is to determine if providing in clinic point-of-care autonomous AI diabetic retinopathy exams improves screening rates compared to standard of care referral to an eye care provider, in a randomized…
- Trial name
- ACCESS (NCT05131451)
- Testing
- Point of Care Autonomous AI diabetic retinopathy exam
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Johns Hopkins University
Coronary Disease
Platelet Activation Markers in Pediatric Cardiac Surgery
In this study the focus will be on correlating the levels of platelet activation markers (proteins that are released when blood cells are activated)to the duration of cardiopulmonary bypass, temperature during cardiopulmonary…
- Trial name
- NCT00450151
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Weill Medical College of Cornell University
Von Hippel-Lindau Disease, Central Nervous System Hemangioblastoma
Pediatric Von Hippel-Lindau Disease: Natural History, Predictive Factors, and Long-Term Functional Outcomes of Central Nervous System Hemangioblastomas
Von Hippel-Lindau (VHL) disease is a rare hereditary cancer predisposition syndrome associated with the development of central nervous system hemangioblastomas from childhood.
- Trial name
- VHL-PED-CHB (NCT07705529)
- Where
- 3 sites in France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity
Effects of Exercise on Arterial Function and Insulin Resistance Syndrome in Pre-pubertal Obese Children
The main purpose of this project is to investigate the effects of an exercise program on arterial function and cardiovascular diseases risk factors in obese and lean pre-pubertal children.
- Trial name
- NCT00801645
- Testing
- Exercise
- Where
- Switzerland
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Hypertension
An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of Age
The purpose of this study is to evaluate in a randomized, double-blind fashion, the long-term safety, tolerability and efficacy profile of aliskiren compared to the active comparator enalapril in children, 6 - 17 years old with…
- Trial name
- NCT01151410
- Testing
- Aliskiren, Enalapril
- Where
- 36 sites in United States, Guatemala and 5 more
- Volunteers
- 208 people
- Sponsor
- Novartis Pharmaceuticals
Pulmonary Congestion, Congenital Heart Disease
Utility of Lung Ultrasound in the Estimation of Extravascular Lung Water in Pediatric Population
Increased extravascular lung water (EVLW) may increase mortality and morbidity in cardiopulmonary pathology. Many factors can cause increased extravascular lung water and pulmonary edema after cardiac surgery.
- Conditions
- Pulmonary Congestion, Congenital Heart Disease, Post-Op Complication
- Trial name
- NCT04417790
- Testing
- Lung ultrasound and EVLW measurement by transpulmonary thermodilution.
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Cardiopulmonary Arrest
Measurement of Cerebral Flow Using Transfontanellar Doppler in Infants Under Cardiopulmonary Bypass
Transfontanellar Doppler can measure the velocity at both the carotid artery and the anterior cerebral artery during cardiopulmonary bypass in congenital heart disease patients.
- Trial name
- NCT01996020
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital